DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opm and TMED7-TICAM2

DIOPT Version :9

Sequence 1:	NP_572994.1	Gene:	opm / 32435	FlyBaseID:	FBgn0264389	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_001157940.1	Gene:	TMED7-TICAM2 / 100302736	HGNCID:	33945	Length:	404	Species:	Homo sapiens

Alignment Length:	209	Identity:	62/209 - (29%)
Similarity:	91/209 - (43%)	Gaps:	26/209 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLGMPGL--VLLLSIAALLLGVQDAEAYDKEMTVYVDAGKTECLYHSVRQGETIDFEYQVIDGGH 67
            |..:.|.  ..||::..|:.|...|    .|:|..:.....:|.|..:.||.....|:|||.|||
Human    10 WAAVAGRWGCRLLALLLLVPGPGGA----SEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGH 70

  Fly    68 GDLDISFTLLDPIGLVIVSDFKKPENVHRHEVAKEGDYRFCFDNSFSMFNRKTVFFELIVEREGE 132
            .|:|.  .|.||.|.|:..:.||..:......:|.|.|:|||.|.||.|..|||:|:..|   ||
Human    71 YDVDC--RLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYFDFQV---GE 130

  Fly   133 ELQGDTQWNEADELTGL-SRDEYYDMKVQDIMDFIGRIRLQLTKARQLQDVLRSHEARDRNLAES 196
            :.......|....||.: |........::.::|:....||:              ||:.|:.||.
Human   131 DPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLR--------------EAQGRSRAED 181

  Fly   197 NFQKVNHWSMVQIS 210
            ...:|.:|..|..|
Human   182 LNTRVAYWHSVDTS 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opm	NP_572994.1	EMP24_GP25L	33..227	CDD:279450	55/179 (31%)
TMED7-TICAM2	NP_001157940.1	EMP24_GP25L	36..189	CDD:279450	52/171 (30%)
TMED7-TICAM2	NP_001157940.1	TIR_2	250..>341	CDD:304906
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000272
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1790
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840