Protein Alignment hiw and mycbp2

DIOPT Version :9

• Sequence 1: NP_001285258.1
• Gene: hiw / 32429
• FlyBaseID: FBgn0030600
• Length: 5233
• Species: Drosophila melanogaster
• Sequence 2: XP_009302823.1
• Gene: mycbp2 / 368439
• ZFINID: ZDB-GENE-030616-132
• Length: 4769
• Species: Danio rerio
• Alignment Length: 5811
• Identity: 1951/5811 - (33%)
• Similarity: 2687/5811 - (46%)
• Gaps: 1685/5811 - (28%)

  Fly     4 LLNPLKYGDHFYELYTNSTRRKMQ-----HDRKVLTKRK-SRKDKSAAAMAAAAAAAVLEGNAGA 62
            ||:.....:.:..:||.:...|.|     ..:|.|:|:| .|:.|..:.:........|:|
Zfish    63 LLSGRALAERYRRIYTTAINDKEQGLNLGRGKKALSKKKLKRRQKVKSKVKTRTKTDTLDG---- 123

  Fly    63 GGLVNPLDPPLVKEQLMILPSFPVAHIELDPNASKFAVFSAIRSTVLEAETRYSLFQEGGAPSGQ 127
                                :|||..|:|..|.|.|.|:..:|..||:.:.:.:........|.|
Zfish   124 --------------------AFPVPDIKLHSNPSAFNVYCNVRHCVLDWQQKEAALALASRNSVQ 168

  Fly   128 SGSNQKKWSNNVNSACCMMCAHSCMISNLLDCSCHAHMAMHGAVGPGNAGPGGPVGVLVDGRIPA 192
            ||
Zfish   169 SG--------------------------------------------------------------- 170

  Fly   193 PVPVVVGGPGLPAEKRPRRDSANSDADSDTEEPTE-REPVYATVPLIVGAGLRSLFELIADARHV 256
                                      |||:||..| ||| :..:|.|:|.||..:||||.:.|..
Zfish   171 --------------------------DSDSEEEEEYREP-FVKLPKIIGIGLCGVFELIKETRFS 208

  Fly   257 HPLLCTKALKALLDVIQGQQPESFKLEPEELINPLYDLLLDLATMPAALNSATGAEANWSAMACA 321
            ||.||.::|:||||::||||||||:.||.:::..|:.|||:.......:|..||  ...:|::||
Zfish   209 HPSLCLRSLQALLDMLQGQQPESFQTEPPDVLESLFHLLLETTVRSTGMNDPTG--QTLTALSCA 271

  Fly   322 ALLGLCIARGDTGKMLKAIAAMLMTPRQLSAQIVQLPVVLATLQHTVISAALNKPTRPDFHSHGV 386
            .|..|.:|.|||||.|:|::|:|......:.|.:|:|.:|..||.:|.:..:.|....::..:|:
Zfish   272 CLFSLVVAWGDTGKTLQAVSAILTNNGSHACQTIQVPTILNALQRSVQAVLVGKIQIQEWFGNGI 336

  Fly   387 PHNSLIDEFPVKLPPLSTGAPITSPAMACDGVFVYLLYGGTLLKIGTGFGGSYKGHIYAQNEDFS 451
            ...:|::::.:|...:......   .:..||.|:|||....|.|:|:|:.|:.:||:|.......
Zfish   337 KRAALMNKWVLKEVNIDDDEHC---LLQTDGSFLYLLCKDGLYKVGSGYSGTVRGHVYNSTSRIR 398

  Fly   452 H--ERSAWLGYSGGQLYFRRTCRRSAG------DQLQMVGLDTLAIKAMSPLSMLHMREGLNYVL 508
            :  |:.:|||::.|.|.:|.....:..      :.|:..|  |:.:..:       ..:|.| ::
Zfish   399 NRKEKRSWLGFAQGCLLYRDMNSHNMAAIKINPETLEQEG--TITVPGL-------QADGQN-II 453

  Fly   509 FTDDDSLHAICSNRDDTLVVKKLNLYHNSYNIDPP-PFELPLQLARKKFRTLGYAAFEDELLNQY 572
            |||.:.::.|.:.:||..||:   :|..|  .||. ..||.|:||||.....|.:.|:
Zfish   454 FTDGEYINQIAACKDDGFVVR---IYATS--SDPALQQELQLKLARKCLHACGISLFD------- 506

  Fly   573 QIQRIQSAHNSFEPKLPAPCRDADVDVMGMACGKEFGLVRASNGRVYYYGKSAALGLKCVGRTPT 637
                       .|..|.......|.:...:..|:||.|::.::|::||.||..:||:| .|...:
Zfish   507 -----------LEKDLHIISTGFDEEAALIGAGREFALMKTASGKIYYTGKYQSLGIK-QGGPSS 559

  Fly   638 LKLTELVISKAANIVHVAVGHDGIHALLVNDDGTVFFAGTARRGEDGDSSKNRRQPKAVKPKKMT 702
            .|..||.::|:..||..:|||||.|||||.:||:|||.|:|.:||||:|:|:|||||..|||||.
Zfish   560 GKWVELPVTKSPKIVQFSVGHDGSHALLVAEDGSVFFTGSASKGEDGESTKSRRQPKPYKPKKMI 624

  Fly   703 KIDGHVVVHAACNNGTSAFVTKTGKLIMYGKDTAHCDAMGFVSELLEQHVTKVALGKAHCVALNA 767
            |::..:.|:.|||||:|:.|||.|:|.|:|||..:.|:...||:|....||:||:||||...|..
Zfish   625 KLETKMAVYTACNNGSSSIVTKDGELYMFGKDAIYSDSTCQVSDLKGHFVTQVAMGKAHTCVLTK 689

  Fly   768 KGQLFSFGLNNKGQCGRIFNKLQPVKDVPPFASSSTAAACFASLLPLDKRL------KLDFSTLC 826
            .|::::||:||||||||         |....:.:..|.........:|:.|      |.:.|.:|
Zfish   690 SGEVWTFGVNNKGQCGR---------DTGAMSQAGKAFGVENMATAMDEDLEDELDEKEEKSMMC 745

  Fly   827 DYDDHNLVQGQCRVCVICRECTGYNVSCVSALNVPLDQRLAGSICPCGHGDAGCAKCGLCAACIA 891
            ....|.....||.||.:|.:||||..||||:   ....|:.|.||.||.|::||:.||.|.||..
Zfish   746 QPGMHKWKLDQCMVCTVCGDCTGYGASCVSS---GRPDRVPGGICGCGSGESGCSSCGCCKACAR 807

  Fly   892 LQDSDEAK-------------------TELKPPP-----SDVQQRQQRSKTLIMRR---KERKG- 928
            ..|..||:                   ..:.|||     ..:|.||:..:..|.||   :|.:|
Zfish   808 ELDGQEARQRGIFDAVKEMIPLDLLLAVPVPPPPGVNIEEHIQIRQEEKRQRINRRHRLEEGRGP 872

  Fly   929 ------------------------------ELETGAAGGGAATPTDLDKDPPRVAPLAPQLLQLT 963
                                          :|:.|::..|       |||..::....|..::..
Zfish   873 LVFPGPLFMNQREQVLARLRPLQAVKLMREKLKDGSSERG-------DKDASKITTYPPGAVRFD 930

  Fly   964 SSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQ-VPGAISQVAAGSNH 1027
            .....|||:||.||:|||...|:|||||..|:||||.||:.....|..|| :||..:||.|||||
Zfish   931 CELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGSPTLVQALPGPSTQVTAGSNH 995

  Fly  1028 TVLLTSKGMVYTFGNYQKGQLGRLPSDYGLKPPPQDDDSPVGAGSDGGAGGSPTVAPVGMPGPER 1092
            |.:|...|.|:|||::.||||||                                 |:
Zfish   996 TAVLLMDGQVFTFGSFSKGQLGR---------------------------------PI------- 1020

  Fly  1093 SQSPANVQPSGSKEMPPLLPVLTQRQKFLWNCSPGAVFGLGPCYGKKVTWIGANGDQTFIKIDES 1157
                        .:||            .||..|..:..:|..||:|.|||||:|||||::|||:
Zfish  1021 ------------LDMP------------YWNAKPSPMPNIGAKYGRKATWIGASGDQTFLRIDEA 1061

  Fly  1158 LITAQMLPKMHVVANKKTILLIP---SIPLSFHTLSINRRDGSCTAHYRGQTNFVKLMQAQPEQQ 1219
            ||.:.:|....:.|||..|.|:|   |.|..|..|.||:.||||
Zfish  1062 LINSHVLATSEIFANKHIIGLVPTSISEPPPFKCLLINKLDGSC--------------------- 1105

  Fly  1220 QPEINSNLDVAVTPVADSPAHASTSSLLAALTGTATAGVPINEQMSRSMHEARNQIFEEQLPEVG 1284
                                                          |:.:::.    :|.|...|
Zfish  1106 ----------------------------------------------RTFNDSE----QEDLQGFG 1120

  Fly  1285 SSAAAAAVAAPGTPVSAGSVPRSRRGGKQGTSSPEPIPSPPQLAFTMDPTYNVLWVFDGAARKLR 1349
                                                        ..:||.|:|:|.|....|::.
Zfish  1121 --------------------------------------------LCLDPVYDVIWRFLPVTREMC 1141

  Fly  1350 CHNVVASDI---NDSDANAATYRSLLSPELSLPDRVDSRVARSQASLNLLACLDILTSAQDNIPG 1411
            |:|.|.:|.   ..||..|..  |:|||||:||....:...||..:|::|.|||.|.:.|:
Zfish  1142 CYNAVIADARVPTASDIQALC--SILSPELALPSGSHASTTRSHGALHILGCLDTLAAMQE---- 1200

  Fly  1412 CFEQPLLKQTQQTA--ETQA-------GEFQVVNRFDNFGGGWGYSGHSVEAIRFSADTDIVICG 1467
                  ||....:|  ||||       .::.|||||::.|||||||.||||||||.||.||::.|
Zfish  1201 ------LKMGVASAEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFCADADILLGG 1259

  Fly  1468 FGMFGGRGEYSCKLKLFDLGGDGGGYEKEGILISETKEVPYECGARSKHHILLPKPVSAVAGRWY 1532
            .|:|||||||:.|:|||:||.|||.:|.:|.|::||..:.|:|.||.|:.::..:||....|.||
Zfish  1260 LGLFGGRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEPVLLQLGWWY 1324

  Fly  1533 LVWARIAGPSSDCGSCGQASVTTEDQVVFSFKSSKKANNGTDVNSGQIPAILYRLVTQDCKQTPA 1597
            :.|||::||||||||.|||::||:|.|||.||||||:|||||||:||||.:||||.:.|...:..
Zfish  1325 VAWARVSGPSSDCGSHGQATITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRLPSNDGNASKG 1389

  Fly  1598 -QMDADPVQRISRAFANSVSRECFESLVVLLSWSWDCFKLQLREERDRSRPLQLQQS---LQYLG 1658
             |..::||..:.|.||.:||.:|||||:.:|.|||....|.:.|.|. .:..|...:   |:.|.
Zfish  1390 KQQTSEPVHILKRTFARTVSVDCFESLLSILHWSWTTLVLGVEELRG-LKGFQFTATLLDLERLR 1453

  Fly  1659 YVIKSCLRLLRKYTIEIYPQRNSSTSVATGGGSNAAHGSGVVTTAKSVQSKPNKDKNTPRVVGNA 1723
            :|...||||||.|..:|:|
Zfish  1454 FVGTCCLRLLRVYICDIFP---------------------------------------------- 1472

  Fly  1724 GVMAKYFGDPSTSVAPAMISSASSGGAPSTSASAAVAPGSGTPVTRKTNMENIQLAECIGNVRAL 1788
                                         .|||           |:....|:.:||||:|..|:|
Zfish  1473 -----------------------------ISAS-----------TKAIVEESSKLAECVGKTRSL 1497

  Fly  1789 LIGIF---CDDIFKDIATD-EGY---ELSL--EILDECHLSFVACFDAFYPTSSLKWNCLCDLLA 1844
            |..|.   .|:....:..| :||   .|:|  .:|.|||.:|.|||.:||||.:|:|.||||||.
Zfish  1498 LKKILSEGMDNCLTKLDNDPQGYLSQPLTLLEAVLQECHNTFTACFHSFYPTPALQWACLCDLLN 1562

  Fly  1845 QMDRG-------ALHSRLLSAILAGLCSPSVKLRATF-----------SLLSAAGNERQSIISPS 1891
            .:|:.       ...||||:|:::.||:.||||.:..           ||:.....|..|.:
Zfish  1563 CLDQDIQEANFRTSSSRLLAAVMSALCNTSVKLTSILPIAYDGEVLLRSLVKQVSTENDSAL--- 1624

  Fly  1892 DNSGLPMLSSTDAHPYPVLVEQMIYRTQQEKSDFLSNSWTFKDVLVRLLDIIASPIRSRIEAIYS 1956
                        ||.:|:||..|...:..|::  |....||::||.::|.|:..|:|..:
Zfish  1625 ------------AHRFPLLVAHMEKLSHTEEN--LMGMTTFREVLEKMLVIVVLPVRKSL----- 1670

  Fly  1957 RSLGSLGYPGGKDCVNQGLIDNCCHLLARVLAEIVYQTAMGEYDKLFMPPRTLHSTGA---RFAR 2018
            |....|..|        .|:.|.|.|||.:::|:.......|.|.|    .:|||..|   ||.:
Zfish  1671 RKEVELFSP--------HLVSNTCGLLASIVSELTASALGSEVDGL----NSLHSVKATPNRFTK 1723

  Fly  2019 CDVSRTWNTGNFGPDAIAFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQP-----QHKW 2078
            ....|:|||||..||||.|.||:|||.:.|..||.|.|.::|:||:|.|:.....|     .|:|
Zfish  1724 TSQGRSWNTGNGSPDAICFTVDKPGVVLVGFCVYGGGGIHEYELEVLADDAQTEHPGDSAHSHRW 1788

  Fly  2079 ETLESVSGSYDQDAVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGAQF 2143
            .:||.|.|:|..|...:|:|||:.|..|.:|||.:||:||.:.|:||.:||.|:..|:...|..|
Zfish  1789 TSLELVKGTYCTDDSPSDIAEIRLDKAVPLKENVKYAVRLRNYGSRTANGDGGITTVQCSDGVAF 1853

  Fly  2144 HFYACDLSFNGTTPARGQLPCILYYSTPMKQDGHSASGRTGDGSNVATHLEDRIMLLGPHEVSTR 2208
            .|..|.||.|||...|||:|.||||.:  :.||               .|:.::
Zfish  1854 TFSTCSLSSNGTNQTRGQIPQILYYRS--EYDG---------------DLQSQL----------- 1890

  Fly  2209 DTALQIAADITKKCTELLILARNAMAASCSPSDNSSNHTQTIDSEHNITPIEEHMDINWANNSRT 2273
               |..|.:..|.|:..|
Zfish  1891 ---LSKANEEDKNCSRAL----------------------------------------------- 1905

  Fly  2274 AALPTAIDPQLSTARDLGKRIESFSKGLMETLKFDKRSTNPFEMEIEIGATEVEESADLRNGQSQ 2338
                :.:...:..|:||..|  :|                         |.:||:..:|
Zfish  1906 ----SVVSVVVRAAKDLLHR--AF-------------------------AVDVEDIPEL------ 1933

  Fly  2339 SVSQSQSQSQSVPINGNERTADFEFAEQSAQQSMPQHLHSDSEEAPLEVAGMAAGGGVSVADGSG 2403
                                                                             
Zfish  1934 ----------------------------------------------------------------- 1933

  Fly  2404 GVAGVGSQAAAVQLLEVFNLAASNMFHTLLPLVYAHIANLACSDPKSSVQILGLIKEILPHIAAL 2468
                               |::|::|..||||:.|:|..:|.|.||::|::.||::|:||.::||
Zfish  1934 -------------------LSSSSLFSMLLPLILAYIGPVAASVPKAAVEVFGLVQELLPAVSAL 1979

  Fly  2469 NQLHVSKDQRQPEPAIFATQTSGSGNSN------SSSTTSNHYCVVESDHPYKSASISSYRVEFP 2527
            |       |:...|.....|::.|...|      |:.||||||.|:|||||||.|.::.|:|.||
Zfish  1980 N-------QKYAPPTFNPNQSTDSTTGNQPEQGLSACTTSNHYAVLESDHPYKQAGVTQYKVSFP 2037

  Fly  2528 PCVQWLTIEFDPQCGTAQLEDYLLLSIPMRPASQAPPVPHVDDYLEQADNNVNGAGDRRRNTGGG 2592
            .||:|:|:||||||||||.||.|.|.||.|                                  .
Zfish  2038 DCVRWMTVEFDPQCGTAQPEDVLRLLIPSR----------------------------------S 2068

  Fly  2593 IAGSGAAPNTHQRSASVQLTMASCCRSPGCGNAPGSAAAPSSMPLRSQDPNDREWIVVKKFNTAS 2657
            :..||.                                  ||..|..:..|  .|..:|||:.:|
Zfish  2069 LHFSGL----------------------------------SSKALAHETIN--SWTELKKFSGSS 2097

  Fly  2658 TWLHNVLILPGNCVEFSLETASLYAQDPHNNRYGFKCLVVGYD-NPTSINASNSCLIRLEQELAY 2721
            .|...||:||||...|||||||.|.:|...:.|||||:.|||: ||    ..:..:|:||:||||
Zfish  2098 GWPTAVLVLPGNEALFSLETASDYVKDEKASFYGFKCVAVGYEFNP----GLDEGIIQLEKELAY 2158

  Fly  2722 LGGMCSANLMKKELNLPDDKDV-EDMSGIEE----TINTHHTLLSKGFALSEPQLTVHQALESYL 2781
            ||.:|:|.||||:|.||...:: ||:..:||    ...:|..||.||.|||... |:.:|||..|
Zfish  2159 LGSVCAAALMKKDLALPIGNELEEDLEILEEASLQVCKSHSGLLGKGLALSHSP-TILEALEGNL 2222

  Fly  2782 PIGSQSNERQFLKDFISGAPGSSGARLAAWLQPESRLDPNKCELNTITEPLRYGWPSQVTVTIRD 2846
            |:..|:||..||:|||:....|||.|||.||||:|..||.|..|....:.:|.|||:.|.|..:|
Zfish  2223 PLHLQTNEHSFLEDFITCVQSSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTTVVVQTKD 2287

  Fly  2847 QYGDAVLVPELKVEIKAIPT------------------GSGPNGSATGTGTSCTSVAEVSAPGPN 2893
            ||||.|.||.:|||:||:|.                  |:..| |||||..
Zfish  2288 QYGDVVHVPNMKVEVKAVPVSQKKSIQQENMKKLQRLPGTSSN-SATGTDL-------------- 2337

  Fly  2894 LWMRRASRDTWGWGGMAPPPRINYEPTVKDKMVFKAITFMKPYANYSFEELRYASPVQTRVTELL 2958
                     |:| |..||.....|||.:..:..:.|||.||.|.||||||||:|||...|.:|.:
Zfish  2338 ---------TFG-GHPAPKLEATYEPMIIKEARYIAITMMKAYENYSFEELRFASPTPKRPSENM 2392

  Fly  2959 NAKDMEDGTFSVQWTPSSVGAYCLAVTIDGIPLEEVYRVDVKE---GILPPPTQRNSAQRRPQAP 3020
            ..:...|||:|..|||.:||.|.:.||||||.::....|:||:   |::||.||....:..|| |
Zfish  2393 LIRANTDGTYSANWTPGAVGLYTIHVTIDGIEIDAGLEVEVKDPPKGMIPPGTQMVKPKAEPQ-P 2456

  Fly  3021 SKLRRFQARHSSGLRIRSHPTLQSEQVGVVRVGGVISFIDEIENDDGVWLRLSTESIRQHC-TMG 3084
            ||:|:|.|:.|:|||:||||:|||||:|:|:|.|.|:|||||.|||||||||:.|:::::. .|.
Zfish  2457 SKVRKFVAKDSAGLRVRSHPSLQSEQIGIVQVNGTITFIDEIHNDDGVWLRLNDETVKKYVPNMN 2521

  Fly  3085 WYPTEAWCLQFNQHLARMLLQPVTD---------------------------------------- 3109
            .| ||||||.|||||.|.||.||.:
Zfish  2522 GY-TEAWCLSFNQHLGRSLLVPVDNIFSASQGVRDIDFLSWTTLSCFPQEGRSNLDDYGKESGGR 2585

  Fly  3110 --KEVNPVRKGVG---------------------------------------------------- 3120
              .:.|.:..|.|
Zfish  2586 PSHDANVLDLGAGQSGGPGLYKVVKTGPSGHNIRSCPNLRGIPIGMLVLGNKVKAVGEVINSEGT 2650

  Fly  3121 ------------AEED-------------------VEEQ---------PPVTP----------SA 3135
                        .|.|                   ||||         ||.:|          ::
Zfish  2651 WVQLDKNSVVEFCESDEGEAWSLARDRGGNQYLRHVEEQAVLEHGAQTPPPSPFSVQAFNRGMAS 2715

  Fly  3136 SGEA-------------------SPEPEPD-PSPVLSPAKTKP-----------GRFLSGHQSTN 3169
            ||..                   |.:..|. |||.:.....||           |:.||.....:
Zfish  2716 SGAQGFDYGISNNKGDRLSAILNSIQSGPFLPSPSIFEQAAKPPTSLVHSPFVFGQSLSQQPQPH 2780

  Fly  3170 PFLYPAKHADLAERE-------------------------------------AQVQEEREKEEEQ 3197
            |.|..|....||.||                                     ...||.|..:.:.
Zfish  2781 PQLPNASSRSLASRERVHKSSATGPGTALSSLVLRQKGDRDNMASWSVSPGSKHRQESRSSKTDS 2845

  Fly  3198 VDDEDADD-REPEQEALPAVELL-------------------PAHIGSAIAGVVGGGAIKLQALQ 3242
            ..:...|. :....|:|.|.|.|                   |.|             ..||||
Zfish  2846 HSNRSVDQVKSKNNESLSASEALILKSDTGKLRSDSHSRSHSPNH-------------NTLQAL- 2896

  Fly  3243 KWFKGDA------VDGPQPLTPSHSP-----------PLAGVSVR-----------ELVRAMGGQ 3279
               |.|.      .:.|.|.:.|.||           |.:..|.|           ::..:....
Zfish  2897 ---KADGRTSGLRAESPNPGSRSSSPKQKTFTSGRSSPSSTSSPRSSSPHDKNLPAKVSPSKVHL 2958

  Fly  3280 DSPRGNGNRSQQEQDPEFSLASMRRPNYSASQTAALLSTPKHTPK-------------------- 3324
            |.||..........||: :|...:.|.....:..:....||..||
Zfish  2959 DPPRERSKSDSYTLDPD-TLRKKKVPLMEPLRGRSTSPKPKLPPKESKGGSSNAENRAPSPHVVQ 3022

  Fly  3325 -----------RSAVVASETSGLEDELSLLQITTT-------TTGQGEQQSELQLAT-------T 3364
                       ||:.:.|...| .||.|.|.....       :.|:...:.||:..:       |
Zfish  3023 ENLHSEVVEVCRSSALLSNDEG-NDENSELHNAEEGSSKVHFSIGKAPVKEELESRSSPKVSRKT 3086

  Fly  3365 STASSASKRNPMGPI------------KRAMPPSFAESIRAVFAALLWHEGVVHDAMACASFLKF 3417
            |:.....|::..||:            |:||.||.||..||||||.|||||:|||||||:|||||
Zfish  3087 SSRHVRPKKDKSGPLFKGENVRPTEPAKQAMSPSVAECARAVFAAFLWHEGIVHDAMACSSFLKF 3151

  Fly  3418 HPGLPKEGATVVTRRGESGDPRLQLS-------REQKAQQRHSVEVANAGNYLNIRPSTLETLTK 3475
            :|.|.||.|.:          |..||       :|.|.:.|||:|:::|.|..||.|...: ::|
Zfish  3152 NPELTKEHAPI----------RNSLSCQQGFDEKESKLKNRHSLEISSALNMFNISPHGPD-ISK 3205

  Fly  3476 SGNCSLHNRSKYRKNLLSGGGGAINSGDDTAQKLQALPEMV--------------------SVLP 3520
            .|:.   |::|....|                |...|||..                    |:||
Zfish  3206 MGSI---NKNKVLSML----------------KEPPLPEKCEDGKESVSYEMTSHSSMRSKSILP 3251

  Fly  3521 PALRCLVYLWEQICSGCVQIVQSNALEQREPRLLSPGSRDLNGDADTEGKEGKNSDQASAGEKDL 3585
            ..|:.||..||.|....::....|.:      ..||||     .|..:.||.:...:.:..||
Zfish  3252 LTLQHLVAFWEDISMATIKAATQNMI------FPSPGS-----SAILKKKENEKDSKKTKKEK-- 3303

  Fly  3586 GRKCKRKKK---------------------DDGSWCEICELFLPMPVTYHMRIAHPGCGKSAKGK 3629
                |:|:|                     :..:.||:|....|.|||||||.||||||:.|.|:
Zfish  3304 ----KKKEKAEVRPRGNLFGEMAQLAMGGPEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQ 3364

  Fly  3630 GYNSVGIFCEGWAGNCGEGGKGASSWFLMCDPCRDRYLASCRSANNINSAARQLESSAAEGNELN 3694
            ||||:|.||.|||||||:||.|.|:|:|:||.||::||...::|     |..:::.|..:..:
Zfish  3365 GYNSIGHFCGGWAGNCGDGGIGGSTWYLVCDRCREKYLREKQTA-----AREKVKQSRKKPLQ-- 3422

  Fly  3695 LFGVKSTTLIANAEVYTTMRENATFLLELCSSSSSASGAAGSLAATSSSSKRSPQQMSVVAMPVV 3759
               ||:...:...|.:..:|.||.|||.|.|            ||..|.....|.:.....:|.:
Zfish  3423 ---VKTPRALPTMEAHQVIRANALFLLSLSS------------AAEPSLLCHHPPKPFHSHLPSL 3472

  Fly  3760 IEHQLGNSDLKPSTSRC---SRMARLSGSKFCPGVGSGAFRKSFVGGPPTAPENVWLAPESFACL 3821
            .|   |.|:..|:...|   ..:||.....|........|:          .|..:|...|
Zfish  3473 KE---GVSEELPNKMGCLYLQTLARQHTENFGVYQDDNLFQ----------DEMRYLRSTS---- 3520

  Fly  3822 ECLGTAGHEDLPYEMFGLGPNSNDNGYDRPLSEISYESCEPNNYDMLSGSLAPGTTAAASVGGGN 3886
                      :|.....:.|::..|.::.|.|.:  :|..|:   :.:..:....||..:|
Zfish  3521 ----------VPAPYISVTPDACPNVFEEPGSNM--KSMPPS---LETSPITDSDTAKRTV---- 3566

  Fly  3887 LSKFHRSYSMGQGWASLAQHNHPPPHHPQQQHHQQQQMNLQLQQHQAPPVDGQPKVVYRRRNNST 3951
               |.||||:     ..::::                     :||.|.|  .:.|.|.|||.:|.
Zfish  3567 ---FQRSYSV-----VASEYD---------------------KQHSASP--ARVKAVPRRRVHSG 3600

  Fly  3952 SEGDGSLLICYPSEHLRRLVPQKLLASVSVMQTASGEGTGKDHATGTLGLDQSAGQNGGGNLLLT 4016
            ....||.|:.:||..|.||:                      .|.|:|    |.|:..     ..
Zfish  3601 DAEVGSSLLRHPSPELSRLI----------------------SAHGSL----SKGERN-----FQ 3634

  Fly  4017 RPAMAFITQKHELDRLRAAMRRSLRIAACRIYALQALNWLLRSVTQGVCLHDLMWWFVSSLNPTG 4081
            .|.:||:.|.|:|:.|..||:.:||.:|||::|::|.||||.:|||...|||::|.||:||.|:
Zfish  3635 WPVLAFVIQHHDLEGLEVAMKHALRKSACRVFAMEAFNWLLCNVTQTTSLHDILWHFVASLTPS- 3698

  Fly  4082 GHQPVERGEEASEP---------------ALEHPVAYTQISGRFAHLITQSLHVFLQSVADLTLH 4131
               |.|..||..|.               ..|||::...|:|..||.:..:.|..||:::||.:.
Zfish  3699 ---PFETEEEEDEENKGNKENLEQEKDLGVCEHPLSDIIIAGEAAHPLPHTFHCLLQTISDLMMS 3760

  Fly  4132 LPLGSPLQRVAIQCFGIRFRQADHQFLHSSHVFGNISKILSKSDEQNDAMAVSTILKPDCDVEHN 4196
            ||.||.||::|::|:.::|:|:||||||.|:||.:|:.||||||              |.|.|.:
Zfish  3761 LPSGSSLQQMALRCWSLKFKQSDHQFLHQSNVFHHINNILSKSD--------------DGDSEES 3811

  Fly  4197 QVHSVATG--GSSGAGARLLCYTDLAGMFEVTVSSRPAMAESLTDNSTETFWESDEEDRNKCKII 4259
            ...||.:|  ..|.....:.|..||..:.::..||||||..||||.||||||||.:||:||.|.|
Zfish  3812 FNISVQSGYEAISQELCVVTCLKDLTSVVDIKTSSRPAMIGSLTDGSTETFWESGDEDKNKTKSI 3876

  Fly  4260 ELSLTK-LNYACRYLLVHIDNSRDIQNKVLNVVFYAGQSLGDTNIIKSADVDPKACSWISAKICD 4323
            .:|..| :|  ..|:.||:||||||.|||.:::|..|:::.|...||..|:|.:...|:::::..
Zfish  3877 TISCVKGIN--ASYVSVHVDNSRDIGNKVTSMIFLCGKAVEDLCRIKQIDLDSRHMGWVTSELPG 3939

  Fly  4324 DSCTHFRLELHGPENTLRVRQIKLLG------LPIGGAVGSDDSSDHKHQPHLRLSHASRIQQQI 4382
            ......::||.||||||||||:|:||      :.|.|.:.                 ||..||:.
Zfish  3940 GDHHVIKIELKGPENTLRVRQVKVLGWKEGESIKIAGQIS-----------------ASVAQQKN 3987

  Fly  4383 CEAETLRVFRLITGQVFGKLISNVSSDLVP-PDSAG---IGPPSGGAASTSLLADSLDLREHMVG 4443
            |||||||||||||.|||||||   ..|..| |:...   :..|.|...:.|    ..||:|||||
Zfish  3988 CEAETLRVFRLITSQVFGKLI---CGDAEPTPEQEEKNLLSSPEGEDKAPS----DADLKEHMVG 4045

  Fly  4444 ILFSRSKLSHLQKQVIVHIVHAIRKEAQRAKEDWELANLAHVLKQSPQQQTAPALAASASCESTP 4508
            |:||||||::|||||..|||.|||.||.|.:|:||     |.:.......:.|:
Zfish  4046 IIFSRSKLTNLQKQVCAHIVQAIRMEATRVREEWE-----HAISSKENANSQPS----------- 4094

  Fly  4509 ERSRAPDTYCFEMLSMVLALSGSVVGRSYLSQQHGLLRDLLGLLHTGSDRVQRQVTALLRRILPE 4573
            :...:.|.||||:||||||||||.|||.||:||..||:||..||||.|.|||||||:||||:|||
Zfish  4095 DDDASSDAYCFELLSMVLALSGSNVGRQYLAQQLTLLQDLFSLLHTASPRVQRQVTSLLRRVLPE 4159

  Fly  4574 ITPESFAELLGVQRLPPADYSIAHQSASDFDMSRLGLLDIFLAVIAKSLQLQVKVK-TTVASTGP 4637
            :||...|.::||:.|||||.|....|....|.::||:||:||..|||:|.:|:|.| ||:.
Zfish  4160 VTPMRLASVIGVKALPPADISDIIHSTEKGDWTKLGILDMFLGCIAKALTVQLKAKGTTIV---- 4220

  Fly  4638 SGSGGVSGSSSGNGGAVLKAGQQEKTPAFVRLWSSLDLSVQQLRSRPPTGEPGTTDPFQFDALPP 4702
                |.:|.::|.|...:                                    |.|..|::...
Zfish  4221 ----GTAGMAAGKGVTTV------------------------------------TLPMIFNSSYI 4245

  Fly  4703 RK-ESKRNLNQRWFLNGVISTKQAESIISLIRDLASGKLSEKWSQITKAAIAESVLNLTRLEEIY 4766
            |: ||      .|::.|....:.||.||.|::|:|:|.||:.||::||.||||:::.||::||.:
Zfish  4246 RRGES------HWWMKGSTPPQIAEIIIKLVKDMAAGHLSDAWSRVTKNAIAETIIALTKMEEEH 4304

  Fly  4767 RSPEHCTKTSTLWLALASLCVLERDHVEKLSSGQWSKLCDTR---PLCSNHDDGETAAIIQCETC 4828
            |||..|..|:.|||||||||||::|||::||||:|......:   |:|.|||||||||||.|..|
Zfish  4305 RSPVRCIATTRLWLALASLCVLDQDHVDRLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILCNAC 4369

  Fly  4829 GSLCGDCDRFLHLNRKTRSHKRTVCKEEEEAIRVELHESCGRTKLFWLLALADSKTLKAMVEFRD 4893
            |:||.||||||||:|:||:|:|.|.|||||||:|:|||.|||||||||:|||||||:|||||||:
Zfish  4370 GNLCTDCDRFLHLHRRTRTHQRQVFKEEEEAIKVDLHEGCGRTKLFWLMALADSKTMKAMVEFRE 4434

  Fly  4894 GSHTIISGPQEAVGRCRFCGLTGNSGLLEIGNVCADAQCQEYAANSCLKTKPCGHACGGVTGERK 4958
            .:....|...:|   |||||....:.|..:|:||:|..|||||..:|.||.||||.||||..|..
Zfish  4435 HTGKPASSSSDA---CRFCGTRHGTELSAVGSVCSDQDCQEYAKLACSKTHPCGHPCGGVKNEDL 4496

  Fly  4959 CLPCLQHVCHTRENELAEELRDPKLTQDADDMCMICFVEALSCAPSIHLECGHVFHYHCCKAVLE 5023
            ||||| |.|    ::.|..|:     |||||||||||.||||.||:|.|:|.||||..|.:.|||
Zfish  4497 CLPCL-HGC----DKTATCLK-----QDADDMCMICFTEALSAAPAIQLDCSHVFHLQCTRRVLE 4551

  Fly  5024 KRWSGPRITFGFSLCPICKADIQHPLLSDILEPINGLKQDVKRKALMRIKYEGVVKDTDSKNVNM 5088
            .||.||||||||..|||||..|.|.:|.|:|:||..|.:||:||||||::|||:.|   |:.:.|
Zfish  4552 NRWLGPRITFGFMSCPICKNKINHLVLKDLLDPIKELYEDVRRKALMRLEYEGLHK---SEAITM 4613

  Fly  5089 T---------QLAMDRYAYYVCFKCQKAYYGGEARCDAEI--GEKFDPEELVCGGCSDVARAQMC 5142
            :         ..||:||||||||||:|||:|||||||||.  |:.:||.||:||.||||:|||||
Zfish  4614 SGARFFNNPAGFAMNRYAYYVCFKCKKAYFGGEARCDAEAGQGDDYDPRELICGACSDVSRAQMC 4678

  Fly  5143 PKHGTDFLEYKCRYCCSVAVFFCFGTTHFCDTCHDDFQRLTNIPKVKLPQCPAGPKAKQLLGDEC 5207
            .|||||||||||||||||||||||||||||:.|||||||:|::||.:||.||||||.|||.|.||
Zfish  4679 SKHGTDFLEYKCRYCCSVAVFFCFGTTHFCNACHDDFQRMTSVPKEELPHCPAGPKGKQLEGSEC 4743

  Fly  5208 PLHVMHPPTGEEFALGCGVCRNAQTF 5233
            ||||:||||||||||||||||||.||
Zfish  4744 PLHVVHPPTGEEFALGCGVCRNAHTF 4769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hiw	NP_001285258.1	RCC1_2	752..781	CDD:290274	15/28 (54%)
		RCC1_2	968..997	CDD:290274	17/28 (61%)
		RCC1	985..1031	CDD:278826	26/46 (57%)
		RCC1_2	1018..1047	CDD:290274	15/28 (54%)
		PHR	1437..1585	CDD:285277	91/147 (62%)
		PHR	2015..2167	CDD:285277	71/156 (46%)
		zf-RING_2	4989..5042	CDD:290367	37/52 (71%)
mycbp2	XP_009302823.1	ATS1	615..>1019	CDD:227511	152/455 (33%)
		RCC1_2	674..703	CDD:290274	15/28 (54%)
		RCC1_2	936..964	CDD:290274	17/27 (63%)
		RCC1	951..999	CDD:278826	26/47 (55%)
		RCC1_2	987..1015	CDD:290274	15/27 (56%)
		PHR	1229..1377	CDD:285277	91/147 (62%)
		PHR	1720..1877	CDD:285277	71/156 (46%)
		Filamin	<2384..2425	CDD:279024	18/40 (45%)
		SH3_3	2470..2530	CDD:285451	38/60 (63%)
		zf-RING_2	4517..4570	CDD:290367	37/52 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	987	1.000	Domainoid score	I29
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9005
Inparanoid	1	1.050	2913	1.000	Inparanoid score	I18
OMA	1	1.010	-	-		QHG52738
OrthoDB	1	1.010	-	-		D117289at33208
OrthoFinder	1	1.000	-	-		FOG0005457
OrthoInspector	1	1.000	-	-		oto40684
orthoMCL	1	0.900	-	-		OOG6_103266
Panther	1	1.100	-	-	LDO	PTHR45943
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4602
SonicParanoid	1	1.000	-	-		X4751
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	13.060