Protein Alignment hiw and Mycbp2

DIOPT Version :9

• Sequence 1: NP_001285258.1
• Gene: hiw / 32429
• FlyBaseID: FBgn0030600
• Length: 5233
• Species: Drosophila melanogaster
• Sequence 2: XP_038949112.1
• Gene: Mycbp2 / 290447
• RGDID: 1312048
• Length: 4874
• Species: Rattus norvegicus
• Alignment Length: 5749
• Identity: 1946/5749 - (33%)
• Similarity: 2710/5749 - (47%)
• Gaps: 1570/5749 - (27%)

  Fly     4 LLNPLKYGDHFYELYT----------NSTRRKMQHDRKVLTKRK-SRKDKSAAAMAAAAAAAVLE 57
            ||:.....|.:..:||          :||......::|:|.|:| .||.||.:.:...:.:..||
  Rat   177 LLSGRALADRYRRIYTTALSDRDQAGSSTGYPASRNKKILNKKKLKRKQKSKSKVKTRSKSENLE 241

  Fly    58 GNAGAGGLVNPLDPPLVKEQLMILPSFPVAHIELDPNASKFAVFSAIRSTVLEAETRYSLFQEGG 122
            ..                   :|:|.     |:|..|.|.|.::..:|..|||.:.:.:......
  Rat   242 NT-------------------VIIPD-----IKLHSNPSAFNIYCNVRHCVLEWQKKEASLAAAS 282

  Fly   123 APSGQSGSNQKKWSNNVNSACCMMCAHSCMISNLLDCSCHAHMAMHGAVGPGNAGPGGPVGVLVD 187
            ..|.|||
  Rat   283 RNSVQSG---------------------------------------------------------- 289

  Fly   188 GRIPAPVPVVVGGPGLPAEKRPRRDSANSDADSDTEEPTEREPVYATVPLIVGAGLRSLFELIAD 252
                                         ::|||.||.:...|:  .:|.|:..||..:||||.:
  Rat   290 -----------------------------ESDSDEEEESRELPI--KLPKIIEVGLCEVFELIKE 323

  Fly   253 ARHVHPLLCTKALKALLDVIQGQQPESFKLEPEELINPLYDLLLDLATMPAALNSATGAEANWSA 317
            .|..||.||.::|:|||:|:||||||..:.||.|::..|:.|||::......:|.:||  .:.:|
  Rat   324 TRFSHPSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGVNDSTG--QSLTA 386

  Fly   318 MACAALLGLCIARGDTGKMLKAIAAMLMTPRQLSAQIVQLPVVLATLQHTVISAALNKPTRPDFH 382
            ::||.|..|..:.|:||:.|:||:|:|......:.|.:|:|.:|.:||.:|.:..:.|....|:.
  Rat   387 LSCACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQVQDWF 451

  Fly   383 SHGVPHNSLIDEFPVKLPPLSTGAPITSPAMACDGVFVYLLYGGTLLKIGTGFGGSYKGHIYAQN 447
            |:|:...:|:.::|:|  .:|.... ....:..||.|:|||....|.|||:|:.|:.:||||...
  Rat   452 SNGIKKAALMHKWPLK--EISVDED-DQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGHIYNST 513

  Fly   448 EDFSH--ERSAWLGYSGGQLYFR------RTCRRSAGDQLQMVGLDTLAIKAMSPLSMLHMREGL 504
            ....:  |:.:||||:.|.|.:|      .|..|.:.:.|:..|      ..|.|  ..| .||.
  Rat   514 SRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDG------TVMLP--DCH-TEGQ 569

  Fly   505 NYVLFTDDDSLHAICSNRDDTLVVKKLNLYHNSYNIDPPPF---ELPLQLARKKFRTLGYAAFED 566
            | :||||.:.::.|.::|||..||:       .:.....|.   ||.|:||||.....|.:.|:.
  Rat   570 N-ILFTDGEYINQIAASRDDGFVVR-------IFATSTEPVLQQELQLKLARKCLHACGISLFDL 626

  Fly   567 ELLNQYQIQRIQSAHNSFEPKLPAPCRDADVDVMGMACGKEFGLVRASNGRVYYYGKSAALGLKC 631
            |       :.:......|         |.:..::|  .|:||.|::.:||::||.||..:||:|.
  Rat   627 E-------KDLHIISTGF---------DEESAILG--AGREFALMKTANGKIYYTGKYQSLGIKQ 673

  Fly   632 VGRTPTL-KLTELVISKAANIVHVAVGHDGIHALLVNDDGTVFFAGTARRGEDGDSSKNRRQPKA 695
            .|  |:. |..||.|:|:..|||.:|||||.|||||.:||:|||.|:|.:||||:|:|:|||.|.
  Rat   674 GG--PSAGKWVELPITKSPKIVHFSVGHDGSHALLVAEDGSVFFTGSASKGEDGESAKSRRQSKP 736

  Fly   696 VKPKKMTKIDGHVVVHAACNNGTSAFVTKTGKLIMYGKDTAHCDAMGFVSELLEQHVTKVALGKA 760
            .||||:.|::|.:||..|||||:|:.::|.|:|.|:|||..:.|:...||:|....||:||:|||
  Rat   737 YKPKKIIKMEGKIVVCTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVSDLKGHFVTQVAMGKA 801

  Fly   761 HCVALNAKGQLFSFGLNNKGQCGRIFNKLQPVKDVPPFASSSTAAACFASLLPLDKRL------K 819
            |...|...|::::||:||||||||....:.  :....|...:.|.|       :|:.|      |
  Rat   802 HTCVLMKNGEVWTFGVNNKGQCGRDTGAMN--QGGKGFGVENMATA-------MDEDLEEELDEK 857

  Fly   820 LDFSTLCDYDDHNLVQGQCRVCVICRECTGYNVSCVSALNVPLDQRLAGSICPCGHGDAGCAKCG 884
            .:.|.:|....|.....||.||.:|.:||||..||||:   ....|:.|.||.||.|::|||.||
  Rat   858 DEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSS---GRPDRVPGGICGCGSGESGCAVCG 919

  Fly   885 LCAACIALQDSDEAK--------TELKP---------PPSDVQQ----RQQRSKTLIMRR---KE 925
            .|.||....|..||:        .|:.|         |..::::    ||:..:..::||   ::
  Rat   920 CCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLED 984

  Fly   926 RKGEL----------ETGAAGGGAATPTDL---------------DKDPPRVAPLAPQLLQLTSS 965
            .:|.|          ...|.....:.|..|               :||..:|....|..::....
  Rat   985 GRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDASGERGEKDASKVTTYPPGSVRFDCE 1049

  Fly   966 SPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQ-VPGAISQVAAGSNHTV 1029
            ...|||:||.||:|||...|:|||||..|:||||.||:.....|..|| :||..:||.||||||.
  Rat  1050 VRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTA 1114

  Fly  1030 LLTSKGMVYTFGNYQKGQLGRLPSDYGLKPPPQDDDSPVGAGSDGGAGGSPTVAPVGMPGPERSQ 1094
            :|...|.|:|||::.||||||
  Rat  1115 VLVMDGQVFTFGSFSKGQLGR-------------------------------------------- 1135

  Fly  1095 SPANVQPSGSKEMPPLLPVLTQRQKFLWNCSPGAVFGLGPCYGKKVTWIGANGDQTFIKIDESLI 1159
                          |:|.|.      .||..|..:..:|..||:|.|||||:|||||::|||:||
  Rat  1136 --------------PILDVP------YWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALI 1180

  Fly  1160 TAQMLPKMHVVANKKTILLIP---SIPLSFHTLSINRRDGSCTAHYRGQTNFVKLMQAQPEQQQP 1221
            .:.:|....:.|:|..|.|:|   |.|..|..|.||:.||||
  Rat  1181 NSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSC----------------------- 1222

  Fly  1222 EINSNLDVAVTPVADSPAHASTSSLLAALTGTATAGVPINEQMSRSMHEARNQIFEEQLPEVGSS 1286
                                                            :..|...:|.|...|
  Rat  1223 ------------------------------------------------KTFNDSEQEDLQGFG-- 1237

  Fly  1287 AAAAAVAAPGTPVSAGSVPRSRRGGKQGTSSPEPIPSPPQLAFTMDPTYNVLWVFDGAARKLRCH 1351
                                                      ..:||.|:|||.|..:.|:|.|:
  Rat  1238 ------------------------------------------VCLDPVYDVLWRFRPSTRELWCY 1260

  Fly  1352 NVVASDIN-DSDANAATYRSLLSPELSLPDRVDSRVARSQASLNLLACLDILTSAQDNIPGCFEQ 1415
            |.|.:|.. .|..:..:...:|||||:||....:...||.|:|::|.|||.|.:.||...|.  .
  Rat  1261 NAVVADARLPSATDMQSSCCILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQDLKMGI--A 1323

  Fly  1416 PLLKQTQQTAETQAGE-FQVVNRFDNFGGGWGYSGHSVEAIRFSADTDIVICGFGMFGGRGEYSC 1479
            .:.::||...:..:.| :.:||||::.|||||||.||||||||||||||::.|.|:|||||||:.
  Rat  1324 SIEEETQAVMKVYSKEDYSIVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTA 1388

  Fly  1480 KLKLFDLGGDGGGYEKEGILISETKEVPYECGARSKHHILLPKPVSAVAGRWYLVWARIAGPSSD 1544
            |:|||:||.|||.:|.:|.|::||..:.|:|.||.|:.::..:||...||.||:.|||::|||||
  Rat  1389 KIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSD 1453

  Fly  1545 CGSCGQASVTTEDQVVFSFKSSKKANNGTDVNSGQIPAILYRLVTQDCKQTPA-QMDADPVQRIS 1608
            |||.||||:||:|.|:|.||||||:|||||||:||||.:||||.|.|...:.. |..::||..:.
  Rat  1454 CGSHGQASITTDDGVIFQFKSSKKSNNGTDVNAGQIPQLLYRLPTCDGSTSKGKQQTSEPVHILK 1518

  Fly  1609 RAFANSVSRECFESLVVLLSWSWDCFKLQLREERDRSRPLQLQQS---LQYLGYVIKSCLRLLRK 1670
            |:||.:||.||||||:.:|.|||....|.:.|.|. .:..|...:   |:.|.:|...||||||.
  Rat  1519 RSFARTVSVECFESLLSILHWSWTTLVLGVEELRG-LKGFQFTATLLDLERLRFVGTCCLRLLRV 1582

  Fly  1671 YTIEIYPQRNSSTSVATGGGSNAAHGSGVVTTAKSVQSKPNKDKNTPRVVGNAGVMAKYFGDPST 1735
            ||.||||.              :|.|..||.
  Rat  1583 YTCEIYPV--------------SAVGKAVVE---------------------------------- 1599

  Fly  1736 SVAPAMISSASSGGAPSTSASAAVAPGSGTPVTRKTNMENIQLAECIGNVRALLIGIF---CDDI 1797
                                                  |..:||||||..|.||..|.   .|..
  Rat  1600 --------------------------------------ETSKLAECIGKTRTLLRKILSEGVDHC 1626

  Fly  1798 FKDIATD-EGY---ELSL--EILDECHLSFVACFDAFYPTSSLKWNCLCDLLAQMDRG------- 1849
            ...:..| :||   .|||  .:|.|||.:|.|||.:||||.:|:|.||||||..:|:.
  Rat  1627 MVKLDNDPQGYLSQPLSLLESVLQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQDIQEANFK 1691

  Fly  1850 ALHSRLLSAILAGLCSPSVKLRATFSLLSAAGNERQSIISPSDNSGLPMLSSTDAHPYPVLVEQM 1914
            ...||||:|:::.||..||||.:.|.:........:||:.......    .||..|.:|:||..|
  Rat  1692 TSSSRLLAAVMSALCHTSVKLTSLFPIAYDGEVLLRSIVKQVSTEN----ESTLVHRFPLLVGHM 1752

  Fly  1915 IYRTQQEKSDFLSNSWTFKDVLVRLLDIIASPIRSRIEAIYSRSLGSLGYPGGKDCVNQGLIDNC 1979
            ...:|.|::  :|...:|::||.::|.|:..|:|:.:..             ..:..:..|:.|.
  Rat  1753 EKLSQSEEN--ISGMTSFREVLEKMLVIVVLPVRNSLRR-------------ESELFSSHLVSNT 1802

  Fly  1980 CHLLARVLAEIVYQTAMGEYDKLFMPPRTLHSTGA---RFARCDVSRTWNTGNFGPDAIAFAVDR 2041
            |.|||.:::|:.......|.|.|    .:|||..|   ||.:....|:|||||..||||.||||:
  Rat  1803 CGLLASIVSELTASALGSEVDGL----NSLHSVKASANRFTKTSQGRSWNTGNGSPDAICFAVDK 1863

  Fly  2042 PGVAIAGAMVYSGSGSYDYQLELLYD---NTADLQPQHKWETLESVSGSYDQDAVHNDLAEIKFD 2103
            ||:.:.|..||.|.|.::|:||:|.|   ::.|....|:|.:||.|.|:|..|...:|:|||:.|
  Rat  1864 PGIVVVGFSVYGGGGIHEYELEVLVDDSEHSGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLD 1928

  Fly  2104 HPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGAQFHFYACDLSFNGTTPARGQLPCILYY 2168
            ..|.:|||.:||:||.:.|:||.:||.||..|:.|.|..|.|..|.||.|||...|||:|.||||
  Rat  1929 KVVPLKENVKYAVRLRNYGSRTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYY 1993

  Fly  2169 STPMKQDGHSASGRTGDGSNVATHLEDRIMLLGPHEVSTRDTALQIAADITKKCTELLILARNAM 2233
            .:....|                 |:.:::.....|......||.:.:.:.:...:||   ..|:
  Rat  1994 RSEFDGD-----------------LQSQLVSKANEEDKNCSRALSVVSTVVRAAKDLL---HRAL 2038

  Fly  2234 AASCSPSDNSSNHTQTIDSEHNITPIEEHMDINWANNSRTAALPTAIDPQLSTARDLGKRIESFS 2298
            |               :|::          ||                |:|
  Rat  2039 A---------------VDAD----------DI----------------PEL-------------- 2048

  Fly  2299 KGLMETLKFDKRSTNPFEMEIEIGATEVEESADLRNGQSQSVSQSQSQSQSVPINGNERTADFEF 2363
                                                                             
  Rat  2049 ----------------------------------------------------------------- 2048

  Fly  2364 AEQSAQQSMPQHLHSDSEEAPLEVAGMAAGGGVSVADGSGGVAGVGSQAAAVQLLEVFNLAASNM 2428
                                                                       |::|::
  Rat  2049 -----------------------------------------------------------LSSSSL 2054

  Fly  2429 FHTLLPLVYAHIANLACSDPKSSVQILGLIKEILPHIAALNQLHVSKDQRQPEPAIFATQTSGSG 2493
            |..||||:.|:|..:|.:.||.:|::.||::::||.:|.||       |:...||....|::.|.
  Rat  2055 FSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPSVAVLN-------QKYAPPAFNPNQSTDST 2112

  Fly  2494 NSN------SSSTTSNHYCVVESDHPYKSASISSYRVEFPPCVQWLTIEFDPQCGTAQLEDYLLL 2552
            ..|      |:.||||||.|:||:||||.|.:..|:|.||.||:|:||||||||||||.||.|.|
  Rat  2113 TGNQPEQGLSACTTSNHYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRL 2177

  Fly  2553 SIPMRPASQAPPVPHVDDYLEQADNNVNGAGDRRRNTGGGIAGSGAAPNTHQRSASVQLTMASCC 2617
            ..|:|....                                ||.||
  Rat  2178 LTPVRTIQN--------------------------------AGYGA------------------- 2191

  Fly  2618 RSPGCGNAPGSAAAPSSMPLRSQDPNDREWIVVKKFNTASTWLHNVLILPGNCVEFSLETASLYA 2682
                              .:.|...|...||.:||::.:|.|...||:||||...|||||||.|.
  Rat  2192 ------------------KVTSAHENLNSWIELKKYSGSSGWPTMVLVLPGNEALFSLETASDYV 2238

  Fly  2683 QDPHNNRYGFKCLVVGYD-NPTSINASNSCLIRLEQELAYLGGMCSANLMKKELNLPDDKDV-ED 2745
            :|...:.|||||..:||: :|    ..:..:|:||:|||.|||:|:|.||||:|.||...:: ||
  Rat  2239 KDDKASFYGFKCFAIGYEFSP----GPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEED 2299

  Fly  2746 MSGIEE----TINTHHTLLSKGFALSEPQLTVHQALESYLPIGSQSNERQFLKDFISGAPGSSGA 2806
            :..:||    ...||..:|.||.|||... |:.:|||..||:..||||:.||.|||:..|||||.
  Rat  2300 LEILEEAALQVCKTHSGILGKGLALSHSP-TILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGG 2363

  Fly  2807 RLAAWLQPESRLDPNKCELNTITEPLRYGWPSQVTVTIRDQYGDAVLVPELKVEIKAIPTGSG-- 2869
            |||.||||:|..||.|..|....:.:|.|||:.:||..:|||||.|.||.:|||:||:|....
  Rat  2364 RLARWLQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKVEVKAVPVSQKKT 2428

  Fly  2870 -------------PNGSATGTGTSCTSVAEVSAPGPNLWMRRASRDTWGWGGMAPPP-RINYEPT 2920
                         |...|.....|||:                   ...:||:|.|. .::|||.
  Rat  2429 SLQQEQVKKSQRVPGSPAAAAAASCTT-------------------DMTFGGLASPKLDVSYEPM 2474

  Fly  2921 VKDKMVFKAITFMKPYANYSFEELRYASPVQTRVTELLNAKDMEDGTFSVQWTPSSVGAYCLAVT 2985
            :..:..:.|||.||.|.||||||||:|||...|.:|.:..:...|||:...|||.::|.|.:.||
  Rat  2475 IVKEARYIAITMMKVYENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGLYTVHVT 2539

  Fly  2986 IDGIPLEEVYRVDVKE---GILPPPTQRNSAQRRPQAPSKLRRFQARHSSGLRIRSHPTLQSEQV 3047
            ||||.::....|.||:   |::||.||....:..|| |:|:|:|.|:.|:||||||||:|||||:
  Rat  2540 IDGIEIDAGLEVKVKDPPKGMIPPGTQLVKPKADPQ-PNKIRKFVAKDSAGLRIRSHPSLQSEQI 2603

  Fly  3048 GVVRVGGVISFIDEIENDDGVWLRLSTESIRQHC-TMGWYPTEAWCLQFNQHLARMLLQPV---- 3107
            |:|:|.|.|:|||||.|||||||||:.|:||::. .|..| ||||||.|||||.:.||.||
  Rat  2604 GIVKVNGTITFIDEIHNDDGVWLRLNEETIRKYVPNMNGY-TEAWCLSFNQHLGKSLLVPVDNIF 2667

  Fly  3108 ---------------------------TD---KEVNP---------------VRKGVGAEEDVEE 3127
                                       ||   |:||.               :|.|.|..:.|:.
  Rat  2668 NASQGVRDLDVLSWTSKAFFPQEPKTTTDDFFKDVNTCCPQEAAVRERDHPFLRGGPGMYKVVKT 2732

  Fly  3128 QP--------------PV--------------TPSASGE-------------ASPEPE------- 3144
            .|              |:              ..||.|.             .|.|.|
  Rat  2733 GPSGHNIRSCPNLRGIPIGMLVLGNKVKAVGEVTSAEGTWVQLDKNSMVEFCESDEGEAWSLARD 2797

  Fly  3145 ----------------------PDPSP----------------------------VLSPAKTKPG 3159
                                  |.|||                            ||..|..:..
  Rat  2798 RGGNQYLRHEDEQVLLDQNSQTPPPSPFSVQAFSKGASCSAQGFDYGLGNNKVLIVLPTAGDQLS 2862

  Fly  3160 RFLSGHQST---------------------NPFLYPAKHADLAEREAQVQEER------------ 3191
            ..|:..||.                     :||::   ...|:.::.|:|.:|
  Rat  2863 AILNSIQSRPNLPAPSIFDQAAKPPSSLVHSPFVF---GQPLSFQQRQLQSDRGTVSTSSRPVST 2924

  Fly  3192 -------------EKEEEQVDDEDADDREPE-QEALPAVELLPAHIGSAIAGVVGGGAIKLQA-- 3240
                         .|.:.:|....||.::|. .|.|.|.|.|          ::...|.||::
  Rat  2925 SAKSELPSKNSRSVKPDGRVSRTTADQKKPRGTEGLSASESL----------MLKSDAAKLRSDS 2979

  Fly  3241 -----------LQKWFKGDA-------VDGPQPLTPSHSP-------PLAGVSVRELVRAMGGQD 3280
                       ||. .|.|.       .:.|.|.:.|.||       |.:..|.....|:...||
  Rat  2980 HSRSLSPNHNTLQT-LKSDGRVSSSFRAESPGPGSRSSSPKPKTLPTPRSSPSGASSPRSSSPQD 3043

  Fly  3281 S----------------PRGNGNRSQQEQDPEFSLASMRRPNYSASQTAALLSTPKHTPK----- 3324
            .                ||..........||: :|...:.|.....:..:....||..||
  Rat  3044 KNLPQKSTAPAKTKLDPPRERSKSDSYTLDPD-TLRKKKMPLTEPLRGRSTSPKPKPVPKDPKGS 3107

  Fly  3325 -------RSAVVASETSGLEDELSLLQITTTTT-------------------------------G 3351
                   .|..|..|  .|..|  ::::.|::|                               |
  Rat  3108 PGSENRAPSPHVVQE--NLHSE--VVEVCTSSTLKTNGVTDSTCDDSNDFKSVDEGSNKVHFSIG 3168

  Fly  3352 QGEQQSELQL----------ATTSTASSASKRN---------PMGPIKRAMPPSFAESIRAVFAA 3397
            :...:.|.::          |...|.....|.|         .:.|.|:||.||.||..|||||:
  Rat  3169 KAPLKDEQEMRASPKISRKCANRHTRPKKEKSNFLFKGDGAKSLEPAKQAMSPSVAECARAVFAS 3233

  Fly  3398 LLWHEGVVHDAMACASFLKFHPGLPKEGATVVTRRGESGDPRLQLSREQKAQQRHSVEVANAGNY 3462
            .|||||:|||||||:|||||:|.|.||.|.:  |...:..|..: .:|.|.:.|||:|:::|.|.
  Rat  3234 FLWHEGIVHDAMACSSFLKFNPELSKEHAPI--RSSLNSQPPTE-EKEIKLKNRHSLEISSALNM 3295

  Fly  3463 LNIRP-----STLETLTKSGNCSLHNRSKYRKNLLSGGGGAINSGDDTAQKLQALPEMV------ 3516
            .||.|     |.:.::.|:...|:.......:....|             |.:|..||.
  Rat  3296 FNISPHGPDISKMGSINKNKVLSMLKEPPLHEKCEDG-------------KSEATFEMSMHHSVK 3347

  Fly  3517 --SVLPPALRCLVYLWEQICSGCVQIVQSNALEQREPRLLSPGSRDLNGDADTEGKEGKNSDQAS 3579
              |.||..|:.||..||.|....::....|.:      ..||||     .|..:.||.:..::.:
  Rat  3348 SRSPLPLTLQHLVAFWEDISLATIKAASQNMI------FPSPGS-----CAVLKKKECEKENKKT 3401

  Fly  3580 AGEKDLGRKCKRKKK---------------------DDGSWCEICELFLPMPVTYHMRIAHPGCG 3623
            ..||      |:|:|                     :..:.||:|....|.|||||||.||||||
  Rat  3402 KKEK------KKKEKTEIRPRGNLFGEMAQLAVGGPEKDTICELCGESHPYPVTYHMRQAHPGCG 3460

  Fly  3624 KSAKGKGYNSVGIFCEGWAGNCGEGGKGASSWFLMCDPCRDRYLASCRSANNINSAARQLESSAA 3688
            :.|.|:||||:|.||.|||||||:||.|.|:|:|:||.||::||...::|     |..:::.|..
  Rat  3461 RYAGGQGYNSIGHFCGGWAGNCGDGGMGGSTWYLVCDRCREKYLREKQAA-----AREKVKQSRR 3520

  Fly  3689 EGNELNLFGVKSTTLIANAEVYTTMRENATFLLELCSSSSSASGAAGSLAATSSSSKRSPQQMSV 3753
            :..:     ||:...:...|.:..::.||.|||.|.|            ||..|.....|.:...
  Rat  3521 KPMQ-----VKTPRALPTMEAHQVIKANALFLLSLSS------------AAEPSILCYHPAKPFQ 3568

  Fly  3754 VAMPVVIEHQLGNSDLKPSTSRCSRMARLSGSKFCPGVGSGAFRKSFVGGPPTAPENVWLAPESF 3818
            ..:|:|.|   |.|:..|....|..:..|:..          ..::|||   ...:|  |..:..
  Rat  3569 SQLPIVKE---GVSEALPVKMPCLYLQTLARH----------HHENFVG---YQDDN--LFQDEM 3615

  Fly  3819 ACLECLGTAGHEDLPYEMFGLGPNSNDNGYDRPLSEISYESCEPNNYDMLSGSLAPGTTAAASVG 3883
            ..|.      ...:|.....:.|:::.|.::.|         |.|...|      |.:...:.:.
  Rat  3616 RYLR------STSVPAPYISVTPDASPNVFEEP---------ESNMKSM------PPSLETSPIT 3659

  Fly  3884 GGNLSK---FHRSYSMGQGWASLAQHNHPPPHHPQQQHHQQQQMNLQLQQHQAPPVDGQPKVVYR 3945
            ..:|:|   |.||||:     ..::::                     :||...|  .:.|.:.|
  Rat  3660 DTDLAKRTVFQRSYSV-----VASEYD---------------------KQHSILP--ARVKAIPR 3696

  Fly  3946 RRNNSTSEGDGSLLICYPSEHLRRLVPQKLLASVSVMQTASGEGTGKDHATGTLGLDQSAGQNGG 4010
            ||.||.....||.|:.:||..|.||:                    ..|::      .|.|:..
  Rat  3697 RRVNSGDTEVGSSLLRHPSPELSRLI--------------------SAHSS------LSKGERN- 3734

  Fly  4011 GNLLLTRPAMAFITQKHELDRLRAAMRRSLRIAACRIYALQALNWLLRSVTQGVCLHDLMWWFVS 4075
                ...|.:||:.|.|:|:.|..||:::||.:|||::|::|.||||.:|.|...|||::|.||:
  Rat  3735 ----FQWPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFNWLLCNVIQTTSLHDILWHFVA 3795

  Fly  4076 SLNPTGGHQPVERGEEASEP---------------ALEHPVAYTQISGRFAHLITQSLHVFLQSV 4125
            :|.|:    |||..|:..|.               ..|||::...|:|..||.:..:.|..||::
  Rat  3796 ALTPS----PVEAEEDEDEDNKSSKENAEQEKDTRVCEHPLSDIVIAGEAAHPLPHTFHRLLQTI 3856

  Fly  4126 ADLTLHLPLGSPLQRVAIQCFGIRFRQADHQFLHSSHVFGNISKILSKSDEQNDAMAVSTILKPD 4190
            :||.:.||.||.||::|::|:.::|:|:||||||.|:||.:|:.||||||:.:...:.|..::..
  Rat  3857 SDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNVFHHINNILSKSDDGDSEESFSISIQSG 3921

  Fly  4191 CDVEHNQVHSVATGGSSGAGARLLCYTDLAGMFEVTVSSRPAMAESLTDNSTETFWESDEEDRNK 4255
            .:..:.::..|            :|..||..:.::..||||||..||||.||||||||.:||:||
  Rat  3922 FEAMNQELCIV------------MCLKDLTSIVDIKTSSRPAMIGSLTDGSTETFWESGDEDKNK 3974

  Fly  4256 CKIIELSLTK-LNYACRYLLVHIDNSRDIQNKVLNVVFYAGQSLGDTNIIKSADVDPKACSWISA 4319
            .|.|.::..| :|  .||:.||:|||||:.|||.::.|..|:::.|...||..|:|.:...|:::
  Rat  3975 TKTITINCVKGIN--ARYVSVHVDNSRDLGNKVTSMTFLTGKAVEDLCRIKQVDLDSRHIGWVTS 4037

  Fly  4320 KICDDSCTHFRLELHGPENTLRVRQIKLLG------LPIGGAVGSDDSSDHKHQPHLRLSHASRI 4378
            ::........::||.||||||||||:|:||      ..|.|.:.                 ||..
  Rat  4038 ELPGGDNHIIKIELKGPENTLRVRQVKVLGWKDGESTKIAGQIS-----------------ASVA 4085

  Fly  4379 QQQICEAETLRVFRLITGQVFGKLISNVSSDLVP----PDSAGIGPPSGGAASTSLLADSLDLRE 4439
            ||:.|||||||||||||.|||||||   |.|..|    .:.|.:..|.|.....:..:|: ||:|
  Rat  4086 QQRSCEAETLRVFRLITSQVFGKLI---SGDAEPTPEQEEKALLSSPEGEEKVYNATSDA-DLKE 4146

  Fly  4440 HMVGILFSRSKLSHLQKQVIVHIVHAIRKEAQRAKEDWELANLAHVLKQSPQQQTAPALAASASC 4504
            |||||:||||||::|||||..|||.|||.||.|.:|:||     |.:.......:.|:
  Rat  4147 HMVGIIFSRSKLTNLQKQVCAHIVQAIRMEATRVREEWE-----HAISSKENANSQPS------- 4199

  Fly  4505 ESTPERSRAPDTYCFEMLSMVLALSGSVVGRSYLSQQHGLLRDLLGLLHTGSDRVQRQVTALLRR 4569
                :...:.|.||||:||||||||||.|||.||:||..||:||..||||.|.|||||||:||||
  Rat  4200 ----DEDASSDAYCFELLSMVLALSGSNVGRQYLAQQLTLLQDLCSLLHTASPRVQRQVTSLLRR 4260

  Fly  4570 ILPEITPESFAELLGVQRLPPADYSIAHQSASDFDMSRLGLLDIFLAVIAKSLQLQVKVKTTVAS 4634
            :|||:||...|.::||:.|||||.|....|....|.::||:||:||..|||:|.:|:|.|.|..:
  Rat  4261 VLPEVTPNRLASIIGVKSLPPADISDIIHSTEKGDWNKLGILDMFLGCIAKALTVQLKAKGTTIT 4325

  Fly  4635 TGPSGSGGVSGSSSGNGGAVLKAGQQEKTPAFVRLWSSLDLSVQQLRSRPPTGEPGTTDPFQFDA 4699
                   |.:|::.|.|...:                                    |.|..|::
  Rat  4326 -------GTAGTTVGKGVTTV------------------------------------TLPMIFNS 4347

  Fly  4700 LPPRK-ESKRNLNQRWFLNGVISTKQAESIISLIRDLASGKLSEKWSQITKAAIAESVLNLTRLE 4763
            ...|: ||      .|::.|...|:.:|.||.||:|:|:|.|||.||::||.||||:::.||::|
  Rat  4348 SYLRRGES------HWWMKGSTPTQISEIIIKLIKDMAAGHLSEAWSRVTKNAIAETIIALTKME 4406

  Fly  4764 EIYRSPEHCTKTSTLWLALASLCVLERDHVEKLSSGQWSKLCDTR---PLCSNHDDGETAAIIQC 4825
            |.:|||..|..|:.|||||||||||::|||::||||:|......:   |:|.|||||||||||.|
  Rat  4407 EEFRSPVRCIATTRLWLALASLCVLDQDHVDRLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILC 4471

  Fly  4826 ETCGSLCGDCDRFLHLNRKTRSHKRTVCKEEEEAIRVELHESCGRTKLFWLLALADSKTLKAMVE 4890
            ..||:||.||||||||:|:|::|:|.|.|||||||:|:|||.|||||||||:|||||||:|||||
  Rat  4472 NICGNLCTDCDRFLHLHRRTKTHQRQVFKEEEEAIKVDLHEGCGRTKLFWLMALADSKTMKAMVE 4536

  Fly  4891 FRDGSHTIISGPQEAVGRCRFCGLTGNSGLLEIGNVCADAQCQEYAANSCLKTKPCGHACGGVTG 4955
            ||:.:....:...||   |||||....:.|..:|:||:||.|||||..:|.||.||||.||||..
  Rat  4537 FREHTGKPTTSSSEA---CRFCGSRSGTELSAVGSVCSDADCQEYAKIACSKTHPCGHPCGGVRN 4598

  Fly  4956 ERKCLPCLQHVCHTRENELAEELRDPKLTQDADDMCMICFVEALSCAPSIHLECGHVFHYHCCKA 5020
            |..||||| |.|         :.....|.|||||||||||.||||.||:|.|:|.||||..||:.
  Rat  4599 EEHCLPCL-HGC---------DKNATTLKQDADDMCMICFTEALSAAPAIQLDCSHVFHLQCCRR 4653

  Fly  5021 VLEKRWSGPRITFGFSLCPICKADIQHPLLSDILEPINGLKQDVKRKALMRIKYEGVVKDTDSKN 5085
            |||.||.||||||||..|||||..|.|.:|.|:|:||..|.:||:||||||::|||:.|   |:.
  Rat  4654 VLENRWLGPRITFGFISCPICKNKINHIVLKDLLDPIKELYEDVRRKALMRLEYEGLHK---SEA 4715

  Fly  5086 VNMTQL---------AMDRYAYYVCFKCQKAYYGGEARCDAEI--GEKFDPEELVCGGCSDVARA 5139
            :....:         ||:|||||||:||:|||:|||||||||.  |:.:||.||:||.||||:||
  Rat  4716 ITTPGVRFYNDPAGYAMNRYAYYVCYKCRKAYFGGEARCDAEAGQGDDYDPRELICGACSDVSRA 4780

  Fly  5140 QMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCDTCHDDFQRLTNIPKVKLPQCPAGPKAKQLLG 5204
            |||||||||||||||||||||||||||||||||:.|||||||:|:|||.:||.||||||.|||.|
  Rat  4781 QMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCNACHDDFQRMTSIPKEELPHCPAGPKGKQLEG 4845

  Fly  5205 DECPLHVMHPPTGEEFALGCGVCRNAQTF 5233
            .||||||:||||||||||||||||||.||
  Rat  4846 TECPLHVVHPPTGEEFALGCGVCRNAHTF 4874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hiw	NP_001285258.1	RCC1_2	752..781	CDD:290274	15/28 (54%)
		RCC1_2	968..997	CDD:290274	17/28 (61%)
		RCC1	985..1031	CDD:278826	26/46 (57%)
		RCC1_2	1018..1047	CDD:290274	15/28 (54%)
		PHR	1437..1585	CDD:285277	94/147 (64%)
		PHR	2015..2167	CDD:285277	73/154 (47%)
		zf-RING_2	4989..5042	CDD:290367	38/52 (73%)
Mycbp2	XP_038949112.1	ATS1	<637..826	CDD:227511	97/201 (48%)
		ATS1	<793..1134	CDD:227511	121/352 (34%)
		RCC1	1068..1116	CDD:395335	26/47 (55%)
		PHR	1345..1495	CDD:400388	96/149 (64%)
		PHR	1836..1993	CDD:400388	74/156 (47%)
		Filamin	<2505..2556	CDD:421532	19/50 (38%)
		SH3_3	2588..2650	CDD:400512	42/62 (68%)
		APC10-like	3944..>4036	CDD:382862	46/93 (49%)
		Bbox2_MYCBP2	4455..4503	CDD:380857	33/47 (70%)
		RING-H2_PHR	4621..4675	CDD:319377	39/53 (74%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	660	1.000	Domainoid score	I147
eggNOG	1	0.900	-	-		E1_KOG1428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9005
Inparanoid	1	1.050	2731	1.000	Inparanoid score	I23
OMA	1	1.010	-	-		QHG52738
OrthoDB	1	1.010	-	-		D117289at33208
OrthoFinder	1	1.000	-	-		FOG0005457
OrthoInspector	1	1.000	-	-		oto97496
orthoMCL	1	0.900	-	-		OOG6_103266
Panther	1	1.100	-	-	LDO	PTHR45943
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4751
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.930