DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hiw and MYCBP2

DIOPT Version :9

Sequence 1:	NP_001285258.1	Gene:	hiw / 32429	FlyBaseID:	FBgn0030600	Length:	5233	Species:	Drosophila melanogaster
Sequence 2:	XP_006719842.1	Gene:	MYCBP2 / 23077	HGNCID:	23386	Length:	4797	Species:	Homo sapiens

Alignment Length:	5783	Identity:	1949/5783 - (33%)
Similarity:	2718/5783 - (46%)	Gaps:	1605/5783 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLNPLKYGDHFYELYT----------NSTRRKMQHDRKVLTKRK-SRKDKSAAAMAAAAAAAVLE 57
            ||:.....|.:..:||          .|.......::|:|.|:| .||.||.:.:...:.:..||
Human    67 LLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSENLE 131

  Fly    58 GNAGAGGLVNPLDPPLVKEQLMILPSFPVAHIELDPNASKFAVFSAIRSTVLEAETRYSLFQEGG 122
            ..                   :|:|.     |:|..|.|.|.::..:|..|||.:.:........
Human   132 NT-------------------VIIPD-----IKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAAS 172

  Fly   123 APSGQSGSNQKKWSNNVNSACCMMCAHSCMISNLLDCSCHAHMAMHGAVGPGNAGPGGPVGVLVD 187
            ..|.|||
Human   173 KNSVQSG---------------------------------------------------------- 179

  Fly   188 GRIPAPVPVVVGGPGLPAEKRPRRDSANSDADSDTEEPTEREPVYATVPLIVGAGLRSLFELIAD 252
                                         ::|||.||.::..|:  .:|.|:..||..:||||.:
Human   180 -----------------------------ESDSDEEEESKEPPI--KLPKIIEVGLCEVFELIKE 213

  Fly   253 ARHVHPLLCTKALKALLDVIQGQQPESFKLEPEELINPLYDLLLDLATMPAALNSATGAEANWSA 317
            .|..||.||.::|:|||:|:||||||..:.||.|::..|:.|||::......:|.:||  .:.:|
Human   214 TRFSHPSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTG--QSLTA 276

  Fly   318 MACAALLGLCIARGDTGKMLKAIAAMLMTPRQLSAQIVQLPVVLATLQHTVISAALNKPTRPDFH 382
            ::||.|..|..:.|:||:.|:||:|:|......:.|.:|:|.:|.:||.:|.:..:.|....|:.
Human   277 LSCACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQIQDWF 341

  Fly   383 SHGVPHNSLIDEFPVKLPPLSTGAPITSPAMACDGVFVYLLYGGTLLKIGTGFGGSYKGHIYAQN 447
            |:|:...:|:.::|:|  .:|.... ....:..||.|:|||....|.|||:|:.|:.:||||...
Human   342 SNGIKKAALMHKWPLK--EISVDED-DQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGHIYNST 403

  Fly   448 EDFSH--ERSAWLGYSGGQLYFR------RTCRRSAGDQLQMVGLDTLAIKAMSPLSMLHMREGL 504
            ....:  |:.:||||:.|.|.:|      .|..|.:.:.|:..|      ..|.|  ..| .||.
Human   404 SRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDG------TVMLP--DCH-TEGQ 459

  Fly   505 NYVLFTDDDSLHAICSNRDDTLVVKKLNLYHNSYNIDPPPF---ELPLQLARKKFRTLGYAAFED 566
            | :||||.:.::.|.::|||..||:       .:.....|.   ||.|:||||.....|.:.|:.
Human   460 N-ILFTDGEYINQIAASRDDGFVVR-------IFATSTEPVLQQELQLKLARKCLHACGISLFDL 516

  Fly   567 ELLNQYQIQRIQSAHNSFEPKLPAPCRDADVDVMGMACGKEFGLVRASNGRVYYYGKSAALGLKC 631
            |       :.:......|         |.:..::|  .|:||.|::.:||::||.||..:||:|.
Human   517 E-------KDLHIISTGF---------DEESAILG--AGREFALMKTANGKIYYTGKYQSLGIKQ 563

  Fly   632 VGRTPTL-KLTELVISKAANIVHVAVGHDGIHALLVNDDGTVFFAGTARRGEDGDSSKNRRQPKA 695
            .|  |:. |..||.|:|:..|||.:|||||.|||||.:||::||.|:|.:||||:|:|:|||.|.
Human   564 GG--PSAGKWVELPITKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKP 626

  Fly   696 VKPKKMTKIDGHVVVHAACNNGTSAFVTKTGKLIMYGKDTAHCDAMGFVSELLEQHVTKVALGKA 760
            .||||:.|::|.:||:.|||||:|:.::|.|:|.|:|||..:.|:...|::|....||:||:|||
Human   627 YKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKA 691

  Fly   761 HCVALNAKGQLFSFGLNNKGQCGRIFNKLQPVKDVPPFASSSTAAACFASLLPLDKRL------K 819
            |...|...|::::||:||||||||....:.  :....|...:.|.|       :|:.|      |
Human   692 HTCVLMKNGEVWTFGVNNKGQCGRDTGAMN--QGGKGFGVENMATA-------MDEDLEEELDEK 747

  Fly   820 LDFSTLCDYDDHNLVQGQCRVCVICRECTGYNVSCVSALNVPLDQRLAGSICPCGHGDAGCAKCG 884
            .:.|.:|....|.....||.||.:|.:||||..||||:   ....|:.|.||.||.|::|||.||
Human   748 DEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSS---GRPDRVPGGICGCGSGESGCAVCG 809

  Fly   885 LCAACIALQDSDEAK--------TELKP---------PPSDVQQ----RQQRSKTLIMRR---KE 925
            .|.||....|..||:        .|:.|         |..::::    ||:..:..::||   :|
Human   810 CCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLEE 874

  Fly   926 RKGEL----------ETGAAGGGAATPTDL---------------DKDPPRVAPLAPQLLQLTSS 965
            .:|.|          ...|.....:.|..|               :||..::....|..::....
Human   875 GRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDCE 939

  Fly   966 SPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQ-VPGAISQVAAGSNHTV 1029
            ...|||:||.||:|||...|:|||||..|:||||.||:.....|..|| :||..:||.||||||.
Human   940 LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTA 1004

  Fly  1030 LLTSKGMVYTFGNYQKGQLGRLPSDYGLKPPPQDDDSPVGAGSDGGAGGSPTVAPVGMPGPERSQ 1094
            :|...|.|:|||::.||||||
Human  1005 VLLMDGQVFTFGSFSKGQLGR-------------------------------------------- 1025

  Fly  1095 SPANVQPSGSKEMPPLLPVLTQRQKFLWNCSPGAVFGLGPCYGKKVTWIGANGDQTFIKIDESLI 1159
                          |:|.|.      .||..|..:..:|..||:|.|||||:|||||::|||:||
Human  1026 --------------PILDVP------YWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALI 1070

  Fly  1160 TAQMLPKMHVVANKKTILLIP---SIPLSFHTLSINRRDGSCTAHYRGQTNFVKLMQAQPEQQQP 1221
            .:.:|....:.|:|..|.|:|   |.|..|..|.||:.||||
Human  1071 NSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSC----------------------- 1112

  Fly  1222 EINSNLDVAVTPVADSPAHASTSSLLAALTGTATAGVPINEQMSRSMHEARNQIFEEQLPEVGSS 1286
                                                            :..|...:|.|...|
Human  1113 ------------------------------------------------KTFNDSEQEDLQGFG-- 1127

  Fly  1287 AAAAAVAAPGTPVSAGSVPRSRRGGKQGTSSPEPIPSPPQLAFTMDPTYNVLWVFDGAARKLRCH 1351
                                                      ..:||.|:|:|.|....|:|.|:
Human  1128 ------------------------------------------VCLDPVYDVIWRFRPNTRELWCY 1150

  Fly  1352 NVVASDIN-DSDANAATYRSLLSPELSLPDRVDSRVARSQASLNLLACLDILTSAQDNIPGCFEQ 1415
            |.|.:|.. .|.|:..:..|:|||||:||....:...||.|:|::|.|||.|.:.||...|
Human  1151 NAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQDLKMG---- 1211

  Fly  1416 PLLKQTQQTAETQA-------GEFQVVNRFDNFGGGWGYSGHSVEAIRFSADTDIVICGFGMFGG 1473
              :..|::  ||||       .::.|||||::.|||||||.||||||||||||||::.|.|:|||
Human  1212 --VASTEE--ETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGG 1272

  Fly  1474 RGEYSCKLKLFDLGGDGGGYEKEGILISETKEVPYECGARSKHHILLPKPVSAVAGRWYLVWARI 1538
            ||||:.|:|||:||.|||.:|.:|.|::||..:.|:|.||.|:.::..:||...||.||:.|||:
Human  1273 RGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARV 1337

  Fly  1539 AGPSSDCGSCGQASVTTEDQVVFSFKSSKKANNGTDVNSGQIPAILYRLVTQDCKQTPA-QMDAD 1602
            :||||||||.||||:||:|.|||.||||||:|||||||:||||.:||||.|.|...:.. |..::
Human  1338 SGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSASKGKQQTSE 1402

  Fly  1603 PVQRISRAFANSVSRECFESLVVLLSWSWDCFKLQLREERDRSRPLQLQQS---LQYLGYVIKSC 1664
            ||..:.|:||.:||.||||||:.:|.|||....|.:.|.|. .:..|...:   |:.|.:|...|
Human  1403 PVHILKRSFARTVSVECFESLLSILHWSWTTLVLGVEELRG-LKGFQFTATLLDLERLRFVGTCC 1466

  Fly  1665 LRLLRKYTIEIYPQRNSSTSVATGGGSNAAHGSGVVTTAKSVQSKPNKDKNTPRVVGNAGVMAKY 1729
            |||||.||.||||                     |..|.|:|..:.:|
Human  1467 LRLLRVYTCEIYP---------------------VSATGKAVVEETSK----------------- 1493

  Fly  1730 FGDPSTSVAPAMISSASSGGAPSTSASAAVAPGSGTPVTRKTNMENIQLAECIGNVRALLIGIF- 1793
                                                            ||||||..|.||..|.
Human  1494 ------------------------------------------------LAECIGKTRTLLRKILS 1510

  Fly  1794 --CDDIFKDIATD-EGY---ELSL--EILDECHLSFVACFDAFYPTSSLKWNCLCDLLAQMDRG- 1849
              .|.....:..| :||   .|||  .:|.|||.:|.|||.:||||.:|:|.||||||..:|:.
Human  1511 EGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQDI 1575

  Fly  1850 ------ALHSRLLSAILAGLCSPSVKLRATFSLLSAAGNERQSIISPSDNSGLPMLSSTDAHPYP 1908
                  ...||||:|:::.||..||||.:.|.:........:||:.......    .||..|.:|
Human  1576 QEANFKTSSSRLLAAVMSALCHTSVKLTSIFPIAYDGEVLLRSIVKQVSTEN----DSTLVHRFP 1636

  Fly  1909 VLVEQMIYRTQQEKSDFLSNSWTFKDVLVRLLDIIASPIRSRIEAIYSRSLGSLGYPGGKDCVNQ 1973
            :||..|...:|.|::  :|...:|::||.::|.|:..|:|:.:..             ..:..:.
Human  1637 LLVAHMEKLSQSEEN--ISGMTSFREVLEKMLVIVVLPVRNSLRR-------------ENELFSS 1686

  Fly  1974 GLIDNCCHLLARVLAEIVYQTAMGEYDKLFMPPRTLHSTGA---RFARCDVSRTWNTGNFGPDAI 2035
            .|:.|.|.|||.:::|:.......|.|.|    .:|||..|   ||.:....|:|||||..||||
Human  1687 HLVSNTCGLLASIVSELTASALGSEVDGL----NSLHSVKASANRFTKTSQGRSWNTGNGSPDAI 1747

  Fly  2036 AFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNT---ADLQPQHKWETLESVSGSYDQDAVHNDL 2097
            .|:||:||:.:.|..||.|.|.::|:||:|.|::   .|....|:|.:||.|.|:|..|...:|:
Human  1748 CFSVDKPGIVVVGFSVYGGGGIHEYELEVLVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDI 1812

  Fly  2098 AEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGAQFHFYACDLSFNGTTPARGQL 2162
            |||:.|..|.:|||.:||:||.:.|:||.:||.||..|:.|.|..|.|..|.||.|||...|||:
Human  1813 AEIRLDKVVPLKENVKYAVRLRNYGSRTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQI 1877

  Fly  2163 PCILYYSTPMKQDGHSASGRTGDGSNVATHLEDRIMLLGPHEVSTRDTALQIAADITKKCTELLI 2227
            |.||||.:....|                 |:.:::.....|......||.:.:.:.:...:||
Human  1878 PQILYYRSEFDGD-----------------LQSQLLSKANEEDKNCSRALSVVSTVVRASKDLL- 1924

  Fly  2228 LARNAMAASCSPSDNSSNHTQTIDSEHNITPIEEHMDINWANNSRTAALPTAIDPQLSTARDLGK 2292
              ..|:|               :|::          ||                |:|
Human  1925 --HRALA---------------VDAD----------DI----------------PEL-------- 1938

  Fly  2293 RIESFSKGLMETLKFDKRSTNPFEMEIEIGATEVEESADLRNGQSQSVSQSQSQSQSVPINGNER 2357

Human  1939 ----------------------------------------------------------------- 1938

  Fly  2358 TADFEFAEQSAQQSMPQHLHSDSEEAPLEVAGMAAGGGVSVADGSGGVAGVGSQAAAVQLLEVFN 2422

Human  1939 ----------------------------------------------------------------- 1938

  Fly  2423 LAASNMFHTLLPLVYAHIANLACSDPKSSVQILGLIKEILPHIAALNQLHVSKDQRQPEPAIFAT 2487
            |::|::|..||||:.|:|..:|.:.||.:|::.||::::||.:|.||       |:...||....
Human  1939 LSSSSLFSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPSVAILN-------QKYAPPAFNPN 1996

  Fly  2488 QTSGSGNSN------SSSTTSNHYCVVESDHPYKSASISSYRVEFPPCVQWLTIEFDPQCGTAQL 2546
            |::.|...|      |:.|||:||.|:||:||||.|.:..|:|.||.||:|:||||||||||||.
Human  1997 QSTDSTTGNQPEQGLSACTTSSHYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQS 2061

  Fly  2547 EDYLLLSIPMRPASQAPPVPHVDDYLEQADNNVNGAGDRRRNTGGGIAGSGAAPNTHQRSASVQL 2611
            ||.|.|.||:|.                                  :..||..|.
Human  2062 EDVLRLLIPVRT----------------------------------VQNSGYGPK---------- 2082

  Fly  2612 TMASCCRSPGCGNAPGSAAAPSSMPLRSQDPNDREWIVVKKFNTASTWLHNVLILPGNCVEFSLE 2676
                                     |.|...|...||.:|||:.:|.|...||:||||...||||
Human  2083 -------------------------LTSVHENLNSWIELKKFSGSSGWPTMVLVLPGNEALFSLE 2122

  Fly  2677 TASLYAQDPHNNRYGFKCLVVGYD-NPTSINASNSCLIRLEQELAYLGGMCSANLMKKELNLPDD 2740
            |||.|.:|...:.|||||..:||: :|    ..:..:|:||:|||.|||:|:|.||||:|.||..
Human  2123 TASDYVKDDKASFYGFKCFAIGYEFSP----GPDEGVIQLEKELANLGGVCAAALMKKDLALPIG 2183

  Fly  2741 KDV-EDMSGIEE----TINTHHTLLSKGFALSEPQLTVHQALESYLPIGSQSNERQFLKDFISGA 2800
            .:: ||:..:||    ...||..:|.||.|||... |:.:|||..||:..||||:.||.|||:..
Human  2184 NELEEDLEILEEAALQVCKTHSGILGKGLALSHSP-TILEALEGNLPLQIQSNEQSFLDDFIACV 2247

  Fly  2801 PGSSGARLAAWLQPESRLDPNKCELNTITEPLRYGWPSQVTVTIRDQYGDAVLVPELKVEIKAIP 2865
            |||||.|||.||||:|..||.|..|....:.:|.|||:.:||..:|||||.|.||.:|||:||:|
Human  2248 PGSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKVEVKAVP 2312

  Fly  2866 TGSGPNGSATGTGTSCTSVAEVSA------PGPNLWMRRASRDTWGWGGMAPPP-RINYEPTVKD 2923
            ...           ...|:.:..|      ||.......:|.....:||:|.|. .::|||.:..
Human  2313 VSQ-----------KKMSLQQDQAKKPQRIPGSPAVTAASSNTDMTYGGLASPKLDVSYEPMIVK 2366

  Fly  2924 KMVFKAITFMKPYANYSFEELRYASPVQTRVTELLNAKDMEDGTFSVQWTPSSVGAYCLAVTIDG 2988
            :..:.|||.||.|.||||||||:|||...|.:|.:..:...|||:...|||.::|.|.|.|||||
Human  2367 EARYIAITMMKVYENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGLYTLHVTIDG 2431

  Fly  2989 IPLEEVYRVDVKE---GILPPPTQRNSAQRRPQAPSKLRRFQARHSSGLRIRSHPTLQSEQVGVV 3050
            |.::....|.||:   |::||.||....:..|| |:|:|:|.|:.|:||||||||:|||||:|:|
Human  2432 IEIDAGLEVKVKDPPKGMIPPGTQLVKPKSEPQ-PNKVRKFVAKDSAGLRIRSHPSLQSEQIGIV 2495

  Fly  3051 RVGGVISFIDEIENDDGVWLRLSTESIRQHC-TMGWYPTEAWCLQFNQHLARMLLQPV------- 3107
            :|.|.|:|||||.|||||||||:.|:|:::. .|..| ||||||.|||||.:.||.||
Human  2496 KVNGTITFIDEIHNDDGVWLRLNDETIKKYVPNMNGY-TEAWCLSFNQHLGKSLLVPVDNIFNAS 2559

  Fly  3108 ------------------------TD---KEVNP---------------VRKGVGAEEDVEEQP- 3129
                                    ||   |::|.               :|.|.|..:.|:..|
Human  2560 QGVRDLDVFSWTSKAFFPQESKTNTDDFFKDINSCCPQEATMQEQDMPFLRGGPGMYKVVKTGPS 2624

  Fly  3130 -------------PV---------------------------------TPSASGEA--------- 3139
                         |:                                 ..|..|||
Human  2625 GHNIRSCPNLRGIPIGMLVLGNKVKAVGEVTNSEGTWVQLDQNSMVEFCESDEGEAWSLARDRGG 2689

  Fly  3140 ----------------SPEPEPDP-------------------------------------SPVL 3151
                            |..|.|.|                                     |.:|
Human  2690 NQYLRHEDEQALLDQNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKVLTVLPTAGDQLSAIL 2754

  Fly  3152 SPAKTKP-------------------------GRFLSGHQSTNPFLYPAKHADLAERE------- 3184
            :..:::|                         |:.||..|   |.|..:...:||.||
Human  2755 NSIQSRPNLPAPSIFDQAAKPPSSLVHSPFVFGQPLSFQQ---PQLQKSPSRNLASRERIYKNYG 2816

  Fly  3185 ----------------------------AQVQEERE---------KEEEQVDDEDADDREPE-QE 3211
                                        |....:.|         |.:.::....||.::|. .|
Human  2817 VAGPASALSSLSHKLKGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGTE 2881

  Fly  3212 ALPAVELLPAHIGSAIAGVVGGGAIKLQA-------------LQKWFKGDA-------------- 3249
            :|.|.|.|          ::...|.||::             ||. .|.|.
Human  2882 SLSASESL----------ILKSDAAKLRSDSHSRSLSPNHNTLQT-LKSDGRMPSSSRAESPGPG 2935

  Fly  3250 --VDGPQPLT--------------PSHSPPLAGVSVRELVRAMGGQDSPRGNGNRSQQEQDPEFS 3298
              :..|:|.|              .|.||....:..:.........|.||..........||: :
Human  2936 SRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPD-T 2999

  Fly  3299 LASMRRPNYSASQTAALLSTPKHTPKRSAVVASETSGLEDEL------------SLLQITTTTT- 3350
            |...:.|.....:..:....||..||.|    :::.|.|:..            .::::.|::|
Human  3000 LRKKKMPLTEPLRGRSTSPKPKSVPKDS----TDSPGSENRAPSPHVVQENLHSEVVEVCTSSTL 3060

  Fly  3351 ------------------------------GQGEQQSELQL-ATTSTASSASKRN---------- 3374
                                          |:...:.|.:: |:...:...:.|:
Human  3061 KTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANRHTRPKKEKSSF 3125

  Fly  3375 --------PMGPIKRAMPPSFAESIRAVFAALLWHEGVVHDAMACASFLKFHPGLPKEGATVVTR 3431
                    |:.|.|:||.||.||..|||||:.|||||:|||||||:|||||||.|.||.|.:
Human  3126 LFKGDGSKPLEPAKQAMSPSVAECARAVFASFLWHEGIVHDAMACSSFLKFHPELSKEHAPI--- 3187

  Fly  3432 RGESGDPRLQLSREQKAQQRHSVEVANAGNYLNIRP-----STLETLTKSGNCSLHNRSKYRKNL 3491
            |......:....:|.|.:.|||:|:::|.|..||.|     |.:.::.|:...|:.......:..
Human  3188 RSSLNSQQPTEEKETKLKNRHSLEISSALNMFNIAPHGPDISKMGSINKNKVLSMLKEPPLHEKC 3252

  Fly  3492 LSGGGGAINSGDDTAQKLQALPEM--------VSVLPPALRCLVYLWEQICSGCVQIVQSNALEQ 3548
            ..|             |.:...||        .|.||..|:.||..||.|....::....|.:
Human  3253 EDG-------------KTETTFEMSMHNTMKSKSPLPLTLQHLVAFWEDISLATIKAASQNMI-- 3302

  Fly  3549 REPRLLSPGSRDLNGDADTEGKEGKNSDQASAGEKDLGRKCKRKKK------------------- 3594
                ..||||     .|..:.||.:..::.|..||      |:|:|
Human  3303 ----FPSPGS-----CAVLKKKECEKENKKSKKEK------KKKEKAEVRPRGNLFGEMAQLAVG 3352

  Fly  3595 --DDGSWCEICELFLPMPVTYHMRIAHPGCGKSAKGKGYNSVGIFCEGWAGNCGEGGKGASSWFL 3657
              :..:.||:|....|.|||||||.||||||:.|.|:||||:|.||.|||||||:||.|.|:|:|
Human  3353 GPEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHFCGGWAGNCGDGGIGGSTWYL 3417

  Fly  3658 MCDPCRDRYLASCRSANNINSAARQLESSAAEGNELNLFGVKSTTLIANAEVYTTMRENATFLLE 3722
            :||.||::||...::|     |..:::.|..:..:     ||:...:...|.:..::.||.|||.
Human  3418 VCDRCREKYLREKQAA-----AREKVKQSRRKPMQ-----VKTPRALPTMEAHQVIKANALFLLS 3472

  Fly  3723 LCSSSSSASGAAGSLAATSSSSKRSPQQMSVVAMPVVIEHQLGNSDLKPSTSRCSRMARLSGSKF 3787
            |.|            ||..|.....|.:.....:|.|.|   |.|:..|....|..:..|:..
Human  3473 LSS------------AAEPSILCYHPAKPFQSQLPSVKE---GISEDLPVKMPCLYLQTLARH-- 3520

  Fly  3788 CPGVGSGAFRKSFVGGPPTAPENVWLAPESFACLECLGTAGHEDLPYEMFGLGPNSNDNGYDRPL 3852
                    ..::|||   ...:|  |..:....|.      ...:|.....:.|:::.|.::.|
Human  3521 --------HHENFVG---YQDDN--LFQDEMRYLR------STSVPAPYISVTPDASPNVFEEP- 3565

  Fly  3853 SEISYESCEPNNYDMLSGSLAPGTTAAASVGGGNLSK---FHRSYSMGQGWASLAQHNHPPPHHP 3914
                    |.|...|      |.:...:.:...:|:|   |.||||:     ..::::
Human  3566 --------ESNMKSM------PPSLETSPITDTDLAKRTVFQRSYSV-----VASEYD------- 3604

  Fly  3915 QQQHHQQQQMNLQLQQHQAPPVDGQPKVVYRRRNNSTSEGDGSLLICYPSEHLRRLVPQKLLASV 3979
                          :||...|  .:.|.:.|||.||.....||.|:.:||..|.||:
Human  3605 --------------KQHSILP--ARVKAIPRRRVNSGDTEVGSSLLRHPSPELSRLI-------- 3645

  Fly  3980 SVMQTASGEGTGKDHATGTLGLDQSAGQNGGGNLLLTRPAMAFITQKHELDRLRAAMRRSLRIAA 4044
                        ..|::      .|.|:..     ...|.:||:.|.|:|:.|..||:::||.:|
Human  3646 ------------SAHSS------LSKGERN-----FQWPVLAFVIQHHDLEGLEIAMKQALRKSA 3687

  Fly  4045 CRIYALQALNWLLRSVTQGVCLHDLMWWFVSSLNPTGGHQPVERGEEASEP-------------- 4095
            ||::|::|.||||.:|.|...|||::|.||:||.|.    |||..||..|.
Human  3688 CRVFAMEAFNWLLCNVIQTTSLHDILWHFVASLTPA----PVEPEEEEDEENKTSKENSEQEKDT 3748

  Fly  4096 -ALEHPVAYTQISGRFAHLITQSLHVFLQSVADLTLHLPLGSPLQRVAIQCFGIRFRQADHQFLH 4159
             ..|||::...|:|..||.:..:.|..||:::||.:.||.||.||::|::|:.::|:|:||||||
Human  3749 RVCEHPLSDIVIAGEAAHPLPHTFHRLLQTISDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLH 3813

  Fly  4160 SSHVFGNISKILSKSDEQNDAMAVSTILKPDCDVEHNQVHSVATG--GSSGAGARLLCYTDLAGM 4222
            .|:||.:|:.||||||              |.|.|.:...|:.:|  ..|.....::|..||..:
Human  3814 QSNVFHHINNILSKSD--------------DGDSEESFSISIQSGFEAMSQELCIVMCLKDLTSI 3864

  Fly  4223 FEVTVSSRPAMAESLTDNSTETFWESDEEDRNKCKIIELSLTK-LNYACRYLLVHIDNSRDIQNK 4286
            .::..||||||..||||.||||||||.:||:||.|.|.::..| :|  .||:.||:|||||:.||
Human  3865 VDIKTSSRPAMIGSLTDGSTETFWESGDEDKNKTKNITINCVKGIN--ARYVSVHVDNSRDLGNK 3927

  Fly  4287 VLNVVFYAGQSLGDTNIIKSADVDPKACSWISAKICDDSCTHFRLELHGPENTLRVRQIKLLG-- 4349
            |.::.|..|:::.|...||..|:|.:...|:::::........::||.||||||||||:|:||
Human  3928 VTSMTFLTGKAVEDLCRIKQVDLDSRHIGWVTSELPGGDNHIIKIELKGPENTLRVRQVKVLGWK 3992

  Fly  4350 ----LPIGGAVGSDDSSDHKHQPHLRLSHASRIQQQICEAETLRVFRLITGQVFGKLISNVSSDL 4410
                ..|.|.:.                 ||..||:.|||||||||||||.|||||||   |.|.
Human  3993 DGESTKIAGQIS-----------------ASVAQQRNCEAETLRVFRLITSQVFGKLI---SGDA 4037

  Fly  4411 VP----PDSAGIGPPSGGAASTSLLADSLDLREHMVGILFSRSKLSHLQKQVIVHIVHAIRKEAQ 4471
            .|    .:.|.:..|.|.....:..:|: ||:||||||:||||||::|||||..|||.|||.||.
Human  4038 EPTPEQEEKALLSSPEGEEKVYNATSDA-DLKEHMVGIIFSRSKLTNLQKQVCAHIVQAIRMEAT 4101

  Fly  4472 RAKEDWELANLAHVLKQSPQQQTAPALAASASCESTP-ERSRAPDTYCFEMLSMVLALSGSVVGR 4535
            |.:|:||     |            |:::..:..|.| :...:.|.||||:||||||||||.|||
Human  4102 RVREEWE-----H------------AISSKENANSQPNDEDASSDAYCFELLSMVLALSGSNVGR 4149

  Fly  4536 SYLSQQHGLLRDLLGLLHTGSDRVQRQVTALLRRILPEITPESFAELLGVQRLPPADYSIAHQSA 4600
            .||:||..||:||..||||.|.|||||||:||||:|||:||...|.::||:.|||||.|....|.
Human  4150 QYLAQQLTLLQDLFSLLHTASPRVQRQVTSLLRRVLPEVTPSRLASIIGVKSLPPADISDIIHST 4214

  Fly  4601 SDFDMSRLGLLDIFLAVIAKSLQLQVKVKTTVASTGPSGSGGVSGSSSGNGGAVLKAGQQEKTPA 4665
            ...|.::||:||:||..|||:|.:|:|.|.|..:       |.:|::.|.|...:
Human  4215 EKGDWNKLGILDMFLGCIAKALTVQLKAKGTTIT-------GTAGTTVGKGVTTV---------- 4262

  Fly  4666 FVRLWSSLDLSVQQLRSRPPTGEPGTTDPFQFDALPPRK-ESKRNLNQRWFLNGVISTKQAESII 4729
                                      |.|..|::...|: ||      .|::.|...|:.:|.||
Human  4263 --------------------------TLPMIFNSSYLRRGES------HWWMKGSTPTQISEIII 4295

  Fly  4730 SLIRDLASGKLSEKWSQITKAAIAESVLNLTRLEEIYRSPEHCTKTSTLWLALASLCVLERDHVE 4794
            .||:|:|:|.|||.||::||.||||:::.||::||.:|||..|..|:.|||||||||||::|||:
Human  4296 KLIKDMAAGHLSEAWSRVTKNAIAETIIALTKMEEEFRSPVRCIATTRLWLALASLCVLDQDHVD 4360

  Fly  4795 KLSSGQWSKLCDTR---PLCSNHDDGETAAIIQCETCGSLCGDCDRFLHLNRKTRSHKRTVCKEE 4856
            :||||:|......:   |:|.|||||||||||.|..||:||.||||||||:|:|::|:|.|.|||
Human  4361 RLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILCNVCGNLCTDCDRFLHLHRRTKTHQRQVFKEE 4425

  Fly  4857 EEAIRVELHESCGRTKLFWLLALADSKTLKAMVEFRDGSHTIISGPQEAVGRCRFCGLTGNSGLL 4921
            ||||:|:|||.|||||||||:|||||||:|||||||:.:....:...||   |||||....:.|.
Human  4426 EEAIKVDLHEGCGRTKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEA---CRFCGSRSGTELS 4487

  Fly  4922 EIGNVCADAQCQEYAANSCLKTKPCGHACGGVTGERKCLPCLQHVCHTRENELAEELRDPKLTQD 4986
            .:|:||:||.|||||..:|.||.||||.||||..|..||||| |.|    ::.|..|:     ||
Human  4488 AVGSVCSDADCQEYAKIACSKTHPCGHPCGGVKNEEHCLPCL-HGC----DKSATSLK-----QD 4542

  Fly  4987 ADDMCMICFVEALSCAPSIHLECGHVFHYHCCKAVLEKRWSGPRITFGFSLCPICKADIQHPLLS 5051
            |||||||||.||||.||:|.|:|.|:||..||:.|||.||.||||||||..|||||..|.|.:|.
Human  4543 ADDMCMICFTEALSAAPAIQLDCSHIFHLQCCRRVLENRWLGPRITFGFISCPICKNKINHIVLK 4607

  Fly  5052 DILEPINGLKQDVKRKALMRIKYEGVVKDTDSKNVNMTQL---------AMDRYAYYVCFKCQKA 5107
            |:|:||..|.:||:||||||::|||:.|   |:.:....:         ||:|||||||:||:||
Human  4608 DLLDPIKELYEDVRRKALMRLEYEGLHK---SEAITTPGVRFYNDPAGYAMNRYAYYVCYKCRKA 4669

  Fly  5108 YYGGEARCDAEI--GEKFDPEELVCGGCSDVARAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTH 5170
            |:|||||||||.  |:.:||.||:||.||||:|||||||||||||||||||||||||||||||||
Human  4670 YFGGEARCDAEAGRGDDYDPRELICGACSDVSRAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTH 4734

  Fly  5171 FCDTCHDDFQRLTNIPKVKLPQCPAGPKAKQLLGDECPLHVMHPPTGEEFALGCGVCRNAQTF 5233
            ||:.|||||||:|:|||.:||.||||||.|||.|.||||||:||||||||||||||||||.||
Human  4735 FCNACHDDFQRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVHPPTGEEFALGCGVCRNAHTF 4797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hiw	NP_001285258.1	RCC1_2	752..781	CDD:290274	15/28 (54%)
		RCC1_2	968..997	CDD:290274	17/28 (61%)
		RCC1	985..1031	CDD:278826	26/46 (57%)
		RCC1_2	1018..1047	CDD:290274	15/28 (54%)
		PHR	1437..1585	CDD:285277	95/147 (65%)
		PHR	2015..2167	CDD:285277	72/154 (47%)
		zf-RING_2	4989..5042	CDD:290367	37/52 (71%)
MYCBP2	XP_006719842.1	ATS1	663..1024	CDD:227511	127/372 (34%)
		RCC1_2	683..712	CDD:290274	15/28 (54%)
		RCC1_2	943..971	CDD:290274	17/27 (63%)
		RCC1	958..1006	CDD:278826	26/47 (55%)
		RCC1_2	994..1022	CDD:290274	15/27 (56%)
		PHR	1236..1384	CDD:285277	95/147 (65%)
		PHR	1727..1882	CDD:285277	72/154 (47%)
		IG_FLMN	<2394..2445	CDD:214720	20/50 (40%)
		SH3_3	2479..2539	CDD:285451	40/60 (67%)
		APC10-like	3867..>3959	CDD:295192	46/93 (49%)
		zf-RING_2	4545..4598	CDD:290367	37/52 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1233
eggNOG	1	0.900	-	-		E1_KOG1428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9005
Inparanoid	1	1.050	2584	1.000	Inparanoid score	I28
Isobase	1	0.950	-	0	Normalized mean entropy	S7357
OMA	1	1.010	-	-		QHG52738
OrthoDB	1	1.010	-	-		D117289at33208
OrthoFinder	1	1.000	-	-		FOG0005457
OrthoInspector	1	1.000	-	-		oto90380
orthoMCL	1	0.900	-	-		OOG6_103266
Panther	1	1.100	-	-	LDO	PTHR45943
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4602
SonicParanoid	1	1.000	-	-		X4751
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.910