DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hiw and F07B7.12

DIOPT Version :9

Sequence 1:NP_001285258.1 Gene:hiw / 32429 FlyBaseID:FBgn0030600 Length:5233 Species:Drosophila melanogaster
Sequence 2:NP_001343654.1 Gene:F07B7.12 / 184118 WormBaseID:WBGene00017190 Length:1964 Species:Caenorhabditis elegans


Alignment Length:2673 Identity:586/2673 - (21%)
Similarity:940/2673 - (35%) Gaps:897/2673 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 GPGGPVGVLVDGRIPAPVPVVVGGPGLPAEKRPRRDSANSDADSDTEEPTEREPVYATVPLIVGA 241
            ||..|..::      |....::...|.|.|...:.|  .|:.::.|....|....|.....:|||
 Worm    88 GPPSPFALV------AIAKSILARFGNPEEVSEKED--GSEEEAGTSGADEEGKQYKNTDQLVGA 144

  Fly   242 GLRSLFELIADARHVHPLLCTKALKALLDVIQGQQPESFKLEPEELINPLYDLLLDLA--TMPAA 304
            .|..:||::.........||.:||::||.:||....:..:.|....::.:..:|..|.  ..|:.
 Worm   145 SLTCIFEVLEQLSRRDAELCVQALESLLSLIQSMPIDCLQSENRLSMSAMMHVLKTLREDACPSV 209

  Fly   305 LNSATGAEANWSAMACAALLGLCIARGD---TGKMLKAIAAMLMTPRQLSA----QIVQLPVVLA 362
            .:.||           :.|:.|.:|.|:   .|..::::..|....| :||    .::|:|..|.
 Worm   210 SSKAT-----------SCLVALSVACGEPEHLGSTIRSLICMKKNIR-MSADSTYDMIQMPENLR 262

  Fly   363 TLQHTVISAAL------NKP---TRPDFHSHGVPHNSLIDEFPVKLPPLSTGAP-----ITSPAM 413
            .|...|...||      |.|   ...|.|.|.|..:..:...|...|  |:..|     |.| .|
 Worm   263 KLLLKVRRKALGGDNTANSPPNWAMVDVHEHSVASSFSLPSLPDSSP--SSDTPDDDNRIHS-TM 324

  Fly   414 ACDGVFVYLLYGGTLLKIGTGFGGSYKGHIYAQNEDFSHERSAWLGYSGGQLYFRR---TCRRSA 475
            ||||.|:|:|....|.|:|||...:..|.:||.|:.....::..:....|.||.||   :|    
 Worm   325 ACDGTFLYILNYVGLYKLGTGLNETISGKLYAANQSLQSSKNVQMYLCNGSLYLRRNYSSC---- 385

  Fly   476 GDQLQMVGLDTLAI--KAMSPLSMLHMREGLNYVLFTDDDSLHAICSNRDDTLVVKKLNLYHNSY 538
               :.::..|:|..  :.:.|.|.      :.:.||||....::.....:.||...:||   :|:
 Worm   386 ---ISVIDTDSLLDIGEVILPPSC------VQHALFTDGTYFYSATLIANSTLSTIQLN---DSF 438

  Fly   539 N-IDPPPFELPLQLARKKFRTLGYAAFEDELLNQYQIQRIQSAHNSFEPKLPAPCRDADVDVMGM 602
            : .:.|......:|...||...|      :|...:|:...          |||......||   :
 Worm   439 SPSNEPSSRRSHRLTDVKFTIQG------DLQVPHQLPEF----------LPANLHPQTVD---L 484

  Fly   603 ACGKEFGLVRASNGRVYYYGKSAALGLKCVGRTPTLKLTELVISKAANIVHVAVGHDGIHALLVN 667
            ...:|...::|.:|:|||.|.....||...|.    ...||.:.:.  ||.::||.|        
 Worm   485 HFTREMAFIQARSGKVYYAGNGTRFGLFETGN----NWMELCLPEP--IVQISVGID-------- 535

  Fly   668 DDGTVFFAGTARRG---EDGDSSKNRRQPKAVKPKKMTKIDGHVVVHAACNNGTSAFVTKTGKLI 729
               |:.|...|..|   ...|..:|.|..:.| |....||     ||...:.....:|::.||:.
 Worm   536 ---TIMFRSGAGHGWIASVDDKKRNGRLRRLV-PSNRRKI-----VHVCASGHVYGYVSENGKIF 591

  Fly   730 MYGKDTAHCDAMG-FVSELLEQHVTKVALGKAHCVALNAKGQLFSFGLNNKGQCGRIFNKLQPVK 793
            |.|..|...:... .::.|....::.:||||:|.||:...|.||::||||..||||:        
 Worm   592 MGGLHTMRVNVSSQMLNGLDNVMISSLALGKSHGVAVTRNGHLFTWGLNNMNQCGRV-------- 648

  Fly   794 DVPPFASSSTAAACFASLLPLDKRLKLDFSTLCDYDDHNLVQGQCRVCVICRECTGYNVSCVSAL 858
                 .|:||.::        .:........:|...:|..:.....||..|..|:...|:|.   
 Worm   649 -----ESTSTTSS--------PRHSGRQEYQICPIGEHTWLTDTPSVCAQCGLCSARGVACG--- 697

  Fly   859 NVPLDQRLAGSICPCGHGDAGCAKCGLCAACIALQDSDEAKTELKPPPSDVQQRQQRSKTLIMRR 923
            .||   |..|::|.||.|::.|.:||||..|..:.:         |......|..|.|.|     
 Worm   698 RVP---RPKGTMCHCGVGESTCLRCGLCRPCGEVTE---------PAQPGRAQHVQFSST----- 745

  Fly   924 KERKGELETGAAGGGAATPTDLDKDPPRVAPLAPQLLQLTSSSP----VVQVACGLHHTVVLTLA 984
                            |.|......|.||         :.|..|    |..|:||..|||:|...
 Worm   746 ----------------AAPQRSTLHPSRV---------ILSQGPHDVKVSSVSCGNFHTVLLASD 785

  Fly   985 GEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPG--AISQVAAGSNHTVLLTSKGMVYTFGNYQKGQ 1047
            ..|:|||||.:||||.||....:.|.:|.:|.  .|.|||||||||:|..:.|.|:|||.:.|||
 Worm   786 RRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAGSNHTILRANDGSVFTFGAFGKGQ 850

  Fly  1048 LGRLPSDYGLKPPPQDDDSPVGAGSDGGAGGSPTVAPVGMPGPERSQSPANVQPSGSKEMPPLLP 1112
            |.|                                                  |:|         
 Worm   851 LAR--------------------------------------------------PAG--------- 856

  Fly  1113 VLTQRQKFLWNCSPGAVFGLGPCYGKKVTWIGANGDQTFIKIDESLITAQMLPKMHVVANKKTIL 1177
                 :|..||..|..|.|.||.:.....||||:||.:.|....:|:::..:.|..:||||..|.
 Worm   857 -----EKAGWNAIPEKVSGFGPGFNAFAGWIGADGDSSIIHSHTALLSSDNILKAQIVANKTNIF 916

  Fly  1178 LIPSIPLSFHTLSINRRDGSCTAHYRGQTNFVKLMQAQPEQQQPEINSNLDVAVTPVADSPAHAS 1242
            :.|            |..|......|.:.|..:                            .|| 
 Worm   917 IFP------------REVGKDYIVIRRKLNVFE----------------------------HHA- 940

  Fly  1243 TSSLLAALTGTATAGVPINEQMSRSMHEARNQIFEEQLPEVGSSAAAAAVAAPGTPVSAGSVPRS 1307
             |......|..||                                                    
 Worm   941 -SDYKCWYTSWAT---------------------------------------------------- 952

  Fly  1308 RRGGKQGTSSPEPIPSPPQLAFTMDPTYNVLWVFDGAARKLRCHNVV-ASDINDSDA-NAATYRS 1370
                                    ||.|::||.::.|..:::.:::. .|:.:..|| ::.|:  
 Worm   953 ------------------------DPKYDMLWYYNSAEMEIKGYDIFKKSEKSVGDAFDSLTF-- 991

  Fly  1371 LLSPELSLPDRVDSRVARSQASLNLLACLDILTSAQDNIPGCFEQPLLKQTQQTAETQAGEFQVV 1435
            |...|.:: ...||....:..||.:.......::...|:...:::...::.|...:|....:.|.
 Worm   992 LAGAEFAV-QVYDSPAYATSMSLGMQLLSATFSANVINLSEFWKEKHGEREQDHEKTIMDGYSVA 1055

  Fly  1436 NRFDNFGGGWGYSGHSVEAIRFSADTDIVICGFGMFGGRGEYSCKLKLF-DLGGDGGGYEKEGIL 1499
            ||||..|||||||.:|||||:|....:|.:.|.|::||||||..||||: .:|.:......|  .
 Worm  1056 NRFDGTGGGWGYSANSVEAIQFKVSKEIRLVGVGLYGGRGEYISKLKLYRQIGTEADELYVE--Q 1118

  Fly  1500 ISETKEVPYECGARSKHHILLPKPVSAVAGRWYLVWARIAGPSSDCGSCGQASVTTEDQVVFSFK 1564
            |:||.|..|:|||.....:|..:|:......|::|.|:|:|||||||:.|:..|.. |.|.|.|:
 Worm  1119 ITETDETVYDCGAHETATLLFSQPIVIQPNHWHVVSAKISGPSSDCGANGKRHVEC-DGVTFQFR 1182

  Fly  1565 SSKKANNGTDVNSGQIPAILYRLVTQDCKQTPAQMDADPVQRISRAFAN--------SVSRECFE 1621
            .|..:||||||:.||||.:.|::|  ...::..:.|::....|||..:|        :|:.|...
 Worm  1183 KSAVSNNGTDVDVGQIPELYYQIV--GGSESRDESDSNKQLSISRDMSNLFSPAALKNVTAEGIG 1245

  Fly  1622 SLVVLLSWSWDCFKLQLREERDR--SRPLQLQQSLQYLGYVIKSCLRLLRKYTIEIYPQRNSSTS 1684
            :|::||.|:..  ::|:.|:.:.  ....:.|.|.:..|:|....::|:.::...:|.:      
 Worm  1246 NLLILLEWALQ--RVQIDEDTNNQVEGSAENQWSQERAGFVAILSMKLISRFVRTVYKE------ 1302

  Fly  1685 VATGGGSNAAHGSGVVTTAKSVQSKPNKDKNTPRVVGNAGVMAKYFGDPSTSVAPAMISSASSGG 1749
                               |....:|..| ...::|....::.::|..                 
 Worm  1303 -------------------KGCHDEPGID-FANKLVNLHSMLLEFFFS----------------- 1330

  Fly  1750 APSTSASAAVAPGSGTPVTRKTNMENIQLAECIGNVRALLIGIFCDDIFKDIATDEGYELSLEIL 1814
                              |..|..||..|.:                 .::...:|||.| ::.:
 Worm  1331 ------------------TDMTGYENRPLIK-----------------KEEKVVEEGYTL-MKCV 1359

  Fly  1815 DECHLSFVACFDAFYPTSSLKWNCLCDLLAQMDRGALHSRLLSAILAGLCSPSVKLRATFSLLSA 1879
            .|....|::....|..:.||   ....|:|.|::|...:.:|::.:.|               |.
 Worm  1360 SEAVKLFISLSHCFMGSRSL---MNAHLIAVMNKGNHEALILTSAIIG---------------SL 1406

  Fly  1880 AGNER---QSIISPSDNSGLPMLSSTDAHPYPVLVEQMIYRTQQEKSDFLSNSWTFKDVLVRLLD 1941
            |..||   |.:.|.:.....|||||            ::.:....:.:.|::..:|.::|     
 Worm  1407 AKIERFAHQLLCSTTTTERFPMLSS------------LLLKHFNCEKETLASLTSFPNIL----- 1454

  Fly  1942 IIASPIRSRIEAIYSRSLGSLGYPGGKDCVNQGLIDNCCHLLARVLAEIVYQTAMGEYDKLFMPP 2006
                      ..:|.::.....|            :|...|...:|.::....|:...|.|..| 
 Worm  1455 ----------RFLYDQTFMRNAY------------ENTSSLAEAILVKVSRDLAIPTDDTLMGP- 1496

  Fly  2007 RTLHSTGARFARCDVSRTWNTGNFGPDAIAFAVDRPGVAIAGAMVY----SGSGSYDYQLELLYD 2067
             .:|.|.:||.|.....||:..:...|||||.||..|:.:.|..:|    ....::..::.:|..
 Worm  1497 -VVHQTSSRFRRRSAQPTWDMSDGCADAIAFRVDSEGIKLHGFGIYLPTEPDRRNFVGEIMMLSP 1560

  Fly  2068 NTADLQPQHKWETLESVSGSYDQDAVHNDLAEIKFDHPVHIKENARYALRL-CSQGARTCSGDAG 2131
            ::::     ||..|..|:.  :..:...::..::|...|.:.....||::: ..:..:|..|:.|
 Worm  1561 DSSE-----KWTCLLRVTA--EMSSEEKEVGIVRFPEYVLLSPGVTYAVKVNMMKNTKTFCGEGG 1618

  Fly  2132 MPAVRGPCGAQFHFYACDLSFNGTTPARGQLPCILY------YSTPMKQDGHSASGRTGDGSNVA 2190
            :..|....||:..|..|.:|.||||..|||||.::|      .|..:||:               
 Worm  1619 VTQVHLLNGARLFFSGCSMSQNGTTVQRGQLPYLIYSILDQSNSLQIKQE--------------- 1668

  Fly  2191 THLEDRIMLLGPHEVSTRDTALQIAADITKKCTELLILARNAMAASCSPSDNSSNHTQTIDSEHN 2255
             .:.|...||      .|..|.:|.|.||:         ..|:.|.|               :|.
 Worm  1669 -TIYDTFTLL------LRLMANKIGAAITE---------GGALPACC---------------QHL 1702

  Fly  2256 ITPIEEHMDINWANNSRTAALPTAIDPQLSTARDLGKRIESFSKGLMETLKFDKRSTNPFEMEIE 2320
            ::.|..|:.:                           .:|.|....:|.:               
 Worm  1703 MSHINPHVMV---------------------------YMERFPDKALEMM--------------- 1725

  Fly  2321 IGATEVEESADLRNGQSQSVSQSQSQSQSVP----INGNERTADFEFAEQSAQQSMPQHLHS-DS 2380
                                   .:..|.:|    :||.||.                 .|| ||
 Worm  1726 -----------------------STMEQLIPMVSNLNGVERV-----------------FHSYDS 1750

  Fly  2381 EEAPLEVAGMAAGGGVSVADGSGGVAGVGSQAAAVQLLEVFNLAASNMFHTLLPLVYAHIANLAC 2445
                               |.||                                         |
 Worm  1751 -------------------DDSG-----------------------------------------C 1755

  Fly  2446 SDPKSSVQILGLIKEILPHIAALNQLHVSKDQRQPEPAIFATQTSGSGNSNSSSTTSNHYCVVES 2510
            ..|.|     |::                                         ||     ||||
 Worm  1756 DTPYS-----GIV-----------------------------------------TT-----VVES 1769

  Fly  2511 DHPYKSASISSYRVEFPPCVQWLTIEFDPQCGTAQLEDYLLLSIPMRPASQAPPVPHVDDYLEQA 2575
            .||||..:.||..:.|.. ..::.:.|.|.|.|||.:|.|.:.:            .:|::    
 Worm  1770 QHPYKPNTSSSMVLLFEE-ADYICVRFSPDCQTAQFDDQLTIYL------------KIDEH---- 1817

  Fly  2576 DNNVNGAGDRRRNTGGGIAGSGAAPNTHQRSASVQLTMASCCRSPGCGNAPGSAAAPSSMPLRSQ 2640
                                                                     |.||:   
 Worm  1818 ---------------------------------------------------------SYMPI--- 1822

  Fly  2641 DPNDREWIVVKKFNTASTWLHNVLILPGNCVEFSLETASLYAQDPHNNRYGFKCLVVGYDNPTSI 2705
               :|.:        .|.|....:||||||:.|.|:.:|..........:|:...|.||     :
 Worm  1823 ---ERCY--------GSEWPSYPMILPGNCLMFVLDASSAVEGATSEQMFGYHVTVTGY-----L 1871

  Fly  2706 NASNSCLIRLEQELAYLGGMCSANLMKKELNLP-DDKDVEDMSGIEE----TINTHHTLLSKGFA 2765
            ...|...:||||:|.:|    |||..:....|| :..::|.:|..|:    ....|.:||.||.:
 Worm  1872 VGYNDSTMRLEQDLVWL----SANACRIMTQLPINPSNIEHLSTAEDDTRHLFEKHGSLLKKGLS 1932

  Fly  2766 LS-EPQLT 2772
            || .|.|:
 Worm  1933 LSHSPTLS 1940

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hiwNP_001285258.1 RCC1_2 752..781 CDD:290274 14/28 (50%)
RCC1_2 968..997 CDD:290274 14/28 (50%)
RCC1 985..1031 CDD:278826 25/47 (53%)
RCC1_2 1018..1047 CDD:290274 17/28 (61%)
PHR 1437..1585 CDD:285277 69/148 (47%)
PHR 2015..2167 CDD:285277 42/156 (27%)
zf-RING_2 4989..5042 CDD:290367
F07B7.12NP_001343654.1 RCC1_2 615..644 CDD:316098 14/28 (50%)
RCC1_2 769..798 CDD:316098 14/28 (50%)
RCC1 787..833 CDD:306840 25/45 (56%)
RCC1_2 821..850 CDD:316098 17/28 (61%)
PHR 1057..1203 CDD:311801 69/148 (47%)
PHR 1504..1654 CDD:311801 42/156 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166972
Domainoid 1 1.000 156 1.000 Domainoid score I2558
eggNOG 1 0.900 - - E1_KOG1428
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H9005
Inparanoid 1 1.050 1328 1.000 Inparanoid score I66
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D117289at33208
OrthoFinder 1 1.000 - - FOG0005457
OrthoInspector 1 1.000 - - otm14395
orthoMCL 1 0.900 - - OOG6_103266
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4602
SonicParanoid 1 1.000 - - X4751
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.690

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