DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eag and SPIK

DIOPT Version :9

Sequence 1:	NP_001036275.1	Gene:	eag / 32428	FlyBaseID:	FBgn0000535	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_180131.3	Gene:	SPIK / 817099	AraportID:	AT2G25600	Length:	888	Species:	Arabidopsis thaliana

Alignment Length:	928	Identity:	191/928 - (20%)
Similarity:	335/928 - (36%)	Gaps:	280/928 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 LARSVTRSRQFSAH---LPTLKDPTKQSN---LAHMMSLSADIMPQYRQEAPKTPPHILLHYCAF 235
            |:|..|.| |:|..   ||:|....:.|.   |...:....|  |:||
plant    37 LSRDGTMS-QYSLSKGLLPSLGANNRSSRDVILPRFIVSPFD--PRYR----------------- 81

  Fly   236 KAIWDWVILCLTFYTAIMVPYNVAFKNKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTFVGPGGE- 299
              .|:..::.|..|||...|:...|..|....:|:|  |:||:..|.:||||.|...|:.....
plant    82 --AWETFLVFLVLYTAWASPFEFGFLQKPRPPLSIL--DNIVNGFFAVDIVLTFFVAFLDKVTYL 142

  Fly   300 VVSDPKVIRMNYLKSWFIIDLLSCLPYDVFNAFDRDE-DGIGSLFSALKVVRLLRLGRVVRKLDR 363
            :|.|||.|...|..:|.|.|::|..||::|.:...:. .|.| :||.|::.||.|:.....:|::
plant   143 LVDDPKRIAWRYASTWLIFDVVSTFPYEIFGSLLHESIQGYG-IFSMLRLWRLRRVSNCFARLEK 206

  Fly   364 YLEYG-----AAMLILLLCFYMLVAHWLACIWYSIGRSDADNGIQYSWL----WKLANVTQSPYS 419
            ..:|.     .:.|:|:..|   |.|..||..|||.....|....:..|    ||     :||.:
plant   207 DRKYSYFWVRCSKLLLVTLF---VIHCGACFLYSIAAHYPDPSKTFMALTDENWK-----ESPIA 263

  Fly   420 YIWSNDTGPELVNGPSRKSMYVTALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYATI 484
            .                  .|.||:|:::|..::.|:|::......|..|.:..|:....|.|.|
plant   264 V------------------RYNTAMYWSITTFSTTGYGDIHGVNSREMTFILFYMVFNLGLSAYI 310

  Fly   485 FGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERVMDYVVSTWAM-TKGLDTEKVLNY 548
            .|::|.::..:|..|.|:.|.:.....|.:.:.:|..|.::::.::...:.. ::||..:::::.
plant   311 IGNMTNLVVHVTGRTRKFRDTIQAASGFGQRNNLPVRLQDQMVAHLCLRYRTDSEGLQQQEIIDS 375

  Fly   549 CPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCFIVT 613
            .||.:::.|..:|..:|.::...|...|:..|..|.......:..|.:.:....|:......:||
plant   376 LPKAIRSSISHYLFYEVVDKIYLFHGISNDLLFQLVTEMKAEYFPPKEDVILQNEAPTDFYILVT 440

  Fly   614 GSLEVIQD----DEVVAILGKGDVFGDQFWKDSAVG-----QSAANVRALTYCDLHAIKRDKLLE 669
            |::::|..    ::||:...:|.|||:       ||     .....||......|..:.|..||.
plant   441 GAVDIIARVNGVEQVVSEAQRGHVFGE-------VGVLCYRPQLFTVRTKRLSQLLRLNRTVLLN 498

  Fly   670 V--------------------------------------------LDFYSAFANSFARNLVLTYN 690
            :                                            |.....||.:...:|:|
plant   499 LVQANVGDGAIIMNNLLQHLKDSEDPVMKGVLADTEHMLAQGKMDLPLSLCFAAARGDDLLL--- 560

  Fly   691 LRHRLIFRKVADVKREKE-------------------LAER------RKNEPQLPQNQDHLVRKI 730
              |:|:.|..:..:.:|:                   |.|.      |.:|..:|     |...|
plant   561 --HQLLRRGSSPNEMDKDGRTALHIAASKGSHYCVVLLLEHGADPNIRDSEGNVP-----LWEAI 618

  Fly   731 FSKFRRTPQVQA----------------------------------GSKELVGGSGQSDVEK--G 759
            ..:.|...::.|                                  |...|..|:|.:.:.:  .
plant   619 IGRHREIAKLLAENGAKLSLDSVSYFSGLAVEKNCLDALKDIIKYGGDVTLPDGNGTTALHRAVS 683

  Fly   760 DGEVERTKL-----------------PAKL----------TLTEDARILSTAAAPSPSPSPSPSS 797
            :|.:|..|.                 |..|          ||..:.|.:.....|.|....||.:
plant   684 EGHLEIVKFLLDQGADLDWPDSYGWTPRGLADHQGNEEIKTLFHNHRPVEKKPKPIPGIPQSPVT 748

  Fly   798 GPP----SARSTRASKWGRLL--GSSSVDSASDTSAKVAVSRSLSARESLRESTAQARQSSTSSS 856
            |.|    |:..|..|  |.|:  |...|         |:..|.|:   :.|.|......::.|:.
plant   749 GKPLMKYSSEPTMHS--GELVLDGGQVV---------VSQKRKLN---NFRNSLFGIISAANSAD 799

  Fly   857 NGGQ-----------GNKVFPKAPKLQASQATLARQDTIDEGGEVDSSPPSRDSRVVI------- 903
            :||:           |:.::|:       :.|::..:..:.||:|...|.|.:..:.|
plant   800 DGGEVPRSPAVPGGGGSMIYPE-------RVTISSPENGETGGKVVLLPNSMEELLKIGENKMGF 857

  Fly   904 --------EGAAVSSATV 913
                    |||.:...|:
plant   858 VPTKVLTREGAEIDDITL 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eag	NP_001036275.1	PAS_9	28..155	CDD:290162
		PAS	40..153	CDD:238075
		Ion_trans	254..499	CDD:278921	70/255 (27%)
		Ion_trans_2	<440..494	CDD:285168	15/53 (28%)
		Crp	565..>702	CDD:223736	33/189 (17%)
		CAP_ED	571..682	CDD:237999	27/163 (17%)
SPIK	NP_180131.3	PLN03192	38..888	CDD:215625	190/927 (20%)
		ANK repeat	548..574	CDD:293786	7/30 (23%)
		ANK repeat	576..607	CDD:293786	2/30 (7%)
		ANK repeat	609..671	CDD:293786	8/66 (12%)
		ANK repeat	673..704	CDD:293786	4/30 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	111	1.000	Domainoid score	I2073
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm987
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910