DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eag and Kcnh1

DIOPT Version :9

Sequence 1:	NP_001036275.1	Gene:	eag / 32428	FlyBaseID:	FBgn0000535	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	XP_017454422.1	Gene:	Kcnh1 / 65198	RGDID:	68398	Length:	989	Species:	Rattus norvegicus

Alignment Length:	1109	Identity:	533/1109 - (48%)
Similarity:	685/1109 - (61%)	Gaps:	214/1109 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPGGRRGLVAPQNTFLENIIRRSNSQPDSSFLLANAQIVDFPIVYCNESFCKISGYNRAEVMQKS 65
            |.|||||||||||||||||:||||   |::|:|.||||||:||||.|:.|||:|||:||||||||
  Rat     3 MAGGRRGLVAPQNTFLENIVRRSN---DTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

  Fly    66 CRYVCGFMYGELTDKETVGRLEYTLENQQQDQFEILLYKKNNLQCGCALSQFGKAQTQETPLWLL 130
            .  .|.|||||||||:||.::..|.||.:.:.||||:||||                 .||:|..
  Rat    65 S--ACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKN-----------------RTPVWFF 110

  Fly   131 LQVAPIRNERDLVVLFLLTFRDITALKQPIDSEDTKGVLGLSKFAKLARSVTRSR----QFSAHL 191
            :::||||||:|.|||||.||.||||.||||:.:..|   |..|||:|.|::|.||    |.:..:
  Rat   111 VKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCK---GWGKFARLTRALTSSRGVLQQLAPSV 172

  Fly   192 PTLKDPTKQSNLAHMMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPY 256
            ...::..|.|.||.::.|.:||:|||:||||||||||:||||.||..|||:||.|||||||:|||
  Rat   173 QKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPY 237

  Fly   257 NVAFKNKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYLKSWFIIDLL 321
            ||:||.: ..:|:.|||||||||||.:|||||||||||||.|||:||||:|||||||:||:||||
  Rat   238 NVSFKTR-QNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLL 301

  Fly   322 SCLPYDVFNAFD---------------------------RDEDGIGSLFSALKVVRLLRLGRVVR 359
            |||||||.|||:                           |:..||.||||:||||||||||||.|
  Rat   302 SCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVAR 366

  Fly   360 KLDRYLEYGAAMLILLLCFYMLVAHWLACIWYSIG-----RSDADNGIQYSWLWKLANVTQSPYS 419
            |||.|:|||||:|:||:|.:.|.|||:||||||||     ..|.......|||::||....:||.
  Rat   367 KLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQ 431

  Fly   420 YIWSNDTGP-ELVNGPSRKSMYVTALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYAT 483
            :   |.:|. :...|||:.|:|:::||||||.:|||||||:|..||.||:|.:.:|:|.:|||||
  Rat   432 F---NGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYAT 493

  Fly   484 IFGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDTEKVLNY 548
            |||:||||.|||.:.|.:||:|||:||:|:||::|||.||||||||:||||:|::|:||||||..
  Rat   494 IFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQI 558

  Fly   549 CPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCFIVT 613
            |||||:||||||||||||.||||||||||||||||||.|...|.|||||:||.|||:|||||:|:
  Rat   559 CPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVS 623

  Fly   614 GSLEVIQDDEVVAILGKGDVFGDQFWKDSAVGQSAANVRALTYCDLHAIKRDKLLEVLDFYSAFA 678
            |||||||||||||||||||||||.|||::.:.||.||||||||||||.||||.|.:||:||:||:
  Rat   624 GSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFS 688

  Fly   679 NSFARNLVLTYNLRHRLIFRKVADVKREKELAERRKNEPQLPQNQDHLVRKIFSKFRRTPQ---- 739
            :||:|||:||||||.|::|||::|||||:|...:||||..|....||.||::|.:||:..:
  Rat   689 HSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLA 753

  Fly   740 VQAGSKELVGGSGQSDVEKGDGEVERTKLPAKLTLTEDARILSTAAAP----------------- 787
            .:.|.::|    ...|||||:...:.|.....|.......:..:.|.|
  Rat   754 AERGGRDL----DDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAASTSTVSDHAKL 814

  Fly   788 ----SPSPSPSPSSGPPSARSTRASKWGRLLGSSSVDSASDTSAKVAVSRSLSARESLRESTAQA 848
                |....|....|.|:.|    ..|.|.  ..:.....|.: ||:.:.|:   |:|.|.|
  Rat   815 HAPGSECLGPKAGGGDPAKR----KGWARF--KDACGKGEDWN-KVSKAESM---ETLPERT--- 866

  Fly   849 RQSSTSSSNGGQGNKVFPKAPKLQASQATLARQDTIDEGGEVDSSPPSRDSRVVIEGAAVSSATV 913
                              ||    :.:|||.:.|:.|.|
  Rat   867 ------------------KA----SGEATLKKTDSCDSG-------------------------- 883

  Fly   914 GPSPPVATTSSAAAGAGVSGGPGSGGTVVAIVTKADRNLALERERQIEMASSRATTSDTYDTGLR 978
                                           :||:|  |.|:...:......|:
  Rat   884 -------------------------------ITKSD--LRLDNVGEARSPQDRS----------- 904

  Fly   979 ETPPTLA----------QRDLIATVLDMKVDVRLELQRMQQRIGRIEDLLGELVKRLAPGAGSGG 1033
               |.||          ::.|.||||::|.:::.:::.:..::..||..|.|:: |:....||..
  Rat   905 ---PILAEVKHSFYPIPEQTLQATVLEVKHELKEDIKALNAKMTSIEKQLSEIL-RILMSRGSSQ 965

  Fly  1034 NAPD 1037
            :..|
  Rat   966 SPQD 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eag	NP_001036275.1	PAS_9	28..155	CDD:290162	70/126 (56%)
		PAS	40..153	CDD:238075	60/112 (54%)
		Ion_trans	254..499	CDD:278921	158/277 (57%)
		Ion_trans_2	<440..494	CDD:285168	34/53 (64%)
		Crp	565..>702	CDD:223736	104/136 (76%)
		CAP_ED	571..682	CDD:237999	85/110 (77%)
Kcnh1	XP_017454422.1	PAS_9	39..135	CDD:290162	62/114 (54%)
		PAS	39..133	CDD:238075	60/112 (54%)
		Ion_trans	235..510	CDD:278921	158/278 (57%)
		Ion_trans_2	<450..504	CDD:285168	34/53 (64%)
		Crp	575..>720	CDD:223736	110/144 (76%)
		CAP_ED	581..691	CDD:237999	84/109 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354030
Domainoid	1	1.000	352	1.000	Domainoid score	I975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	975	1.000	Inparanoid score	I300
OMA	1	1.010	-	-		QHG48089
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm45099
orthoMCL	1	0.900	-	-		OOG6_104814
Panther	1	1.100	-	-	LDO	PTHR10217
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870