Protein Alignment eag and kcnh5a

DIOPT Version :10

• Sequence 1: NP_001036275.1
• Gene: eag / 32428
• FlyBaseID: FBgn0000535
• Length: 1270
• Species: Drosophila melanogaster
• Sequence 2: NP_001263209.1
• Gene: kcnh5a / 556304
• ZFINID: ZDB-GENE-061106-2
• Length: 1093
• Species: Danio rerio
• Alignment Length: 1163
• Identity: 547/1163 - (47%)
• Similarity: 717/1163 - (61%)
• Gaps: 188/1163 - (16%)

  Fly     1 MPGGRRGLVAPQNTFLENIIRRSNSQPDSSFLLANAQIVDFPIVYCNESFCKISGYNRAEVMQKS 65
            |.||:|||||||||||||::|||:   ::||||.|||||::||||.|:.|||:|||:||||||||
Zfish     1 MHGGKRGLVAPQNTFLENVVRRSS---ENSFLLGNAQIVEWPIVYSNDGFCKLSGYHRAEVMQKS 62

  Fly    66 CRYVCGFMYGELTDKETVGRLEYTLENQQQDQFEILLYKKNNLQCGCALSQFGKAQTQETPLWLL 130
            .  .|.|||||||||:|:.::..|.:|.:.:.||:||||||                 .||:||.
Zfish    63 S--TCSFMYGELTDKKTIDKVRQTFDNYESNCFEVLLYKKN-----------------RTPVWLH 108

  Fly   131 LQVAPIRNERDLVVLFLLTFRDITALKQPIDSEDTKGVLGLSKFAKLARSVTRSRQFSAHLPTLK 195
            :||||||||.|.|||||.||:|||..||||:.|.|:   |.:|||:|.|::|.||.....|..:.
Zfish   109 MQVAPIRNENDKVVLFLCTFKDITVFKQPIEDETTR---GWTKFARLTRALTNSRGTVQQLTPMN 170

  Fly   196 DPT---KQSNLAHMMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPYN 257
            ...   |.|.||..:.|.:||:|||:||||||||||:||||.||..||||||.||||||||||||
Zfish   171 KTEVSHKHSRLAEALQLGSDILPQYKQEAPKTPPHIILHYCTFKTTWDWVILILTFYTAIMVPYN 235

  Fly   258 VAFKNKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYLKSWFIIDLLS 322
            |:||.| ..::..||:||:|||||.:|||||||||||||||||:||||:|||||||:||:|||||
Zfish   236 VSFKTK-QNNLVWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299

  Fly   323 CLPYDVFNAFDR-DED------------------------------GIGSLFSALKVVRLLRLGR 356
            |||||:.|||:. |||                              |:.||||:|||||||||||
Zfish   300 CLPYDIINAFENVDEDTFVDSSAVGHLPSAGHSPRNATRAEDSVLPGLSSLFSSLKVVRLLRLGR 364

  Fly   357 VVRKLDRYLEYGAAMLILLLCFYMLVAHWLACIWYSIGR----SDADNGIQY-SWLWKLANVTQS 416
            |.||||.|||||||:|:||:|.:.||||||||||||||.    .:|.|.::. |||::||....:
Zfish   365 VARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEATNSLKTDSWLYQLAISIGT 429

  Fly   417 PYSYIWSNDTGP-ELVNGPSRKSMYVTALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALL 480
            ||.|   |.:|. ....|||:.::|:::||||||.:|::||||:|..||.||:|::.||::.:||
Zfish   430 PYRY---NASGSGHWEGGPSKHTLYISSLYFTMTSLTTIGFGNIAPTTDGEKIFSVAMMMVGSLL 491

  Fly   481 YATIFGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDTEKV 545
            ||||||:||||.|||.:.|.:||:||||||:|:||::|||.||||||||:|||||||||:|||||
Zfish   492 YATIFGNVTTIFQQMYTNTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWAMTKGIDTEKV 556

  Fly   546 LNYCPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCF 610
            |:.|||||:|||||||||:|||||||||||||||||:||:.|..:|.|||||::|.|||:|:|||
Zfish   557 LSICPKDMRADICVHLNRQVFNEHPAFRLASDGCLRSLAVEFQTTHCAPGDLIFHAGESVDTLCF 621

  Fly   611 IVTGSLEVIQDDEVVAILGKGDVFGDQFWKDSAVGQSAANVRALTYCDLHAIKRDKLLEVLDFYS 675
            :|:|||||||||||:|||||||||||.|||:|::..:.||||||||||||.|:||.||:||:||:
Zfish   622 VVSGSLEVIQDDEVIAILGKGDVFGDVFWKESSLAHACANVRALTYCDLHVIRRDALLKVLEFYT 686

  Fly   676 AFANSFARNLVLTYNLRHRLIFRKVADVKREKELAERRKNEPQLPQNQDHLVRKIFSKFRRTPQV 740
            ||||||:|||:||.|||.|::|||:||||:|:|....:|||..|....||.|||:|.||::..::
Zfish   687 AFANSFSRNLILTCNLRKRIVFRKIADVKKEEEERRHQKNEVTLSIPVDHPVRKLFQKFKQQKEM 751

  Fly   741 QAGSKELVGGSGQSDVEKGDGEVERTKLPAKLTLTE---DARILSTAAAPSPSPSPSPSSGPPSA 802
            :      ..|..|.|:|:...:||....|....|.:   ..:.....:.|....:|..:..|.|.
Zfish   752 R------TQGPSQYDLERNQFQVEHHLHPLSHQLHQQQYQPQYQGHHSLPHQHVAPMQNGAPGSG 810

  Fly   803 RSTRASKWGRLLGSSSVDSASDTSAKVAVSRSLSARESLRESTAQARQSSTSSSNGGQGNKVFPK 867
            ...         |.|.|         |.||:....:.:|    |.|:...|:.|.|.:..::.|.
Zfish   811 NGN---------GGSCV---------VTVSQITPIQSAL----AYAQTEETNMSEGHEAMELKPN 853

  Fly   868 ---------------APKLQASQATLARQDTIDEGG------EVDSSPPSRDSRVVIEGAAVSSA 911
                           .|:....:..: |...|..|.      |::..|..::.    |...||.
Zfish   854 FGAEDSNCLKVTSPVKPRAGKGRGWM-RFHNIASGSSPMLPLELEKQPQQKEE----EWGDVSQ- 912

  Fly   912 TVGPSPPVATTSSAAAGAGVSGG----PGSGGTVVAIVTKADRNLALERERQIEMASSRATTSD- 971
                  |:...|....|....||    .|..|...: ..:.|.|.||.:   .:...|..|.||
Zfish   913 ------PLNAISEDRKGQEAEGGGSQKEGPSGNSNS-SEETDENSALHK---TDSCDSGITKSDL 967

  Fly   972 ----------TYD-TGLRETP-------------------PTLAQRDLIATVLDMKVDVRLELQR 1006
                      .|| ..:..:|                   |...|..|..::.:.|.:::.::|.
Zfish   968 RIDRVGDSRSPYDRCSMERSPFDQPSPGVVDVTLRGIHFQPVPDQAVLQNSLYEAKQELKGDIQT 1032

  Fly  1007 MQQRIGRIEDLLGELVKRLA----PGAGSGGNAPDNS---------SGQTTP---GDE 1048
            :..|:..:||.:||:::.|:    |...|..::|..:         |...||   ||:
Zfish  1033 LNSRLAALEDQVGEILRLLSEKRKPSPPSQTSSPKTTLECQDIFAVSQPVTPEMEGDD 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eag	NP_001036275.1	PAS_9	40..155	CDD:463873	62/114 (54%)
		Ion_trans	238..499	CDD:459842	173/297 (58%)
		CAP_ED	571..682	CDD:237999	81/110 (74%)
kcnh5a	NP_001263209.1	PAS_9	39..132	CDD:463873	61/111 (55%)
		PLN03192	217..>648	CDD:215625	281/434 (65%)
		cyc_nuc_ocin	<606..705	CDD:274839	73/98 (74%)