DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eag and CngB

DIOPT Version :9

Sequence 1:	NP_001036275.1	Gene:	eag / 32428	FlyBaseID:	FBgn0000535	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_611607.2	Gene:	CngB / 37479	FlyBaseID:	FBgn0266346	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	160/743 - (21%)
Similarity:	273/743 - (36%)	Gaps:	193/743 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 QVAPIRNERDLVVLFLLTFRDITALKQPIDSEDTK-------------GVLGLSKFAKLARSVTR 183
            |..|..||.::|.               :|..||:             |.|. |:..:..|...|
  Fly   325 QRTPSINESEIVA---------------VDEPDTEMNSDVDHRKPSSAGSLD-SQGQQFLRDQVR 373

  Fly   184 S--RQFSAHLPTLKD-----PTKQSNLAHMMSLSADIMPQYRQEAPKTPPHILLHYC-------- 233
            .  |:|:|....:|.     ||..|        |:.:      .:|..||...||..
  Fly   374 HLVRRFTARANKVKSRIELPPTPSS--------SSTV------SSPSPPPTKSLHPSPQHKVRLV 424

  Fly   234 ----------AFKA------IW-----------------------DWV-ILCLTF-YTAIMVPYN 257
                      .|:|      :|                       .|: ::.|:| |.|.::|..
  Fly   425 PAGQSPHRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLR 489

  Fly   258 VAFKNKTSEDVSL-LVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYL-KSWFIIDL 320
            .:|..:|.|:.:: |..|...|:|:.:|:|...|.......|..|.:..:.|.||: |..|.:||
  Fly   490 ASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDL 554

  Fly   321 LSCLPYDV--FNAFDRDEDGIGSLFSALKVVRLLRL---GRVVRKLDRYLEYGAAMLILLLCFYM 380
            |:.||.::  |.        :|:....|:..|..::   ..|.|.|||.:.....:.:.....||
  Fly   555 LALLPLELLYFK--------LGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYM 611

  Fly   381 L-VAHWLACIWYSIGRSDADNGIQYSWLWKLANVTQSPYSYIWSNDTGPELVNGPSRKSMYVTAL 444
            | :.|..|.::|:.  ||.....|..|              ::|....|           ||...
  Fly   612 LYMIHITAALYYAY--SDYQGLGQNRW--------------VFSGKGHP-----------YVRCF 649

  Fly   445 YFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYATIFGHVTTIIQQMTSATAKYHDMLNNV 509
            .|.....||:| .|...|...|.||.....::...::|.:.|.:..||...|....:|..:.:..
  Fly   650 AFATKTATSIG-KNPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDET 713

  Fly   510 REFMKLHEVPKALSERVMDYVVSTWAMTKGLDTEKVLNYCPKDMKADICVHLNRKVFNEHPAFRL 574
            .|:|:...:.:.:..||..:...||...:.||...:|:..|.::|.||.:.::.:..::...|..
  Fly   714 LEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFAD 778

  Fly   575 ASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCFIVTGSLEVI---QDDEVVAILGKGDVFGD 636
            ..:..||.|.:........|||.:...||....:..:..|.::|:   ..|.|:|.|.:|.|||:
  Fly   779 CEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGE 843

  Fly   637 QFWKDSAVG-----QSAANVRALTYCDLHAIKRDKLLEVLDFYSAFANSFARNLVLTYNLRHRLI 696
                .|.:|     :..|:||:..|.:|..:.:..|.||:.:|.. |.:..:.       |.|.:
  Fly   844 ----ISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYPT-AQAILKK-------RARQL 896

  Fly   697 FRKVADVKREKELAERRK--------NEPQLPQNQDHLVRKIFSKFR-RTPQV---QAGSKEL-- 747
            .||.|..:||:|....|.        ..|:.|:....|::.:..... .:|.|   ..|||.:
  Fly   897 MRKNAAREREEERERARSALQADVVIGNPKTPETAPKLLQTVIQALPFESPAVVLITRGSKRMRR 961

  Fly   748 ----------------VGGSGQSDVEKG 759
                            |.|:.::..:||
  Fly   962 KRQSVQMETIVEPKMEVTGAAETQDQKG 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eag	NP_001036275.1	PAS_9	28..155	CDD:290162	5/22 (23%)
		PAS	40..153	CDD:238075	5/20 (25%)
		Ion_trans	254..499	CDD:278921	60/252 (24%)
		Ion_trans_2	<440..494	CDD:285168	15/53 (28%)
		Crp	565..>702	CDD:223736	35/144 (24%)
		CAP_ED	571..682	CDD:237999	31/118 (26%)
CngB	NP_611607.2	Ion_trans	488..704	CDD:278921	59/251 (24%)
		DUF4105	<672..755	CDD:290123	17/82 (21%)
		Crp	769..>898	CDD:223736	33/140 (24%)
		CAP_ED	775..889	CDD:237999	31/118 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840