DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eag and Cngl

DIOPT Version :9

Sequence 1:	NP_001036275.1	Gene:	eag / 32428	FlyBaseID:	FBgn0000535	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster

Alignment Length:	1420	Identity:	277/1420 - (19%)
Similarity:	491/1420 - (34%)	Gaps:	441/1420 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 TQETPLWLLLQVA-----------PIRNERDLVVLFLLTFRDITALKQPIDSEDTKGVLGLSKFA 175
            |:....|:.|:..           |::.|...:..|  :.|.|...::.::...::...|
  Fly   158 TRSNQRWMKLRTTVQISSAIQKKPPLKREDSFLKRF--STRQIPETQETVEDTGSESASG----- 215

  Fly   176 KLARSVTRSRQFSAHLPTLKDPTKQSNLAHMMSLSADIM------------PQYRQEAPKTPPHI 228
            .:.:||.|.|::.....::.:|.:......:|.|:..::            |:.:|..|
  Fly   216 DVDKSVKRRRRYLQKRRSVVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVP------ 274

  Fly   229 LLHYCAFKAIWDWVILCLTFYTAIMVPYNVAFKNKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTF 293
                              ||:                     |:.||:.||:|.:||::...|.:
  Fly   275 ------------------TFW---------------------LICDSMTDVVFILDIIVQLRTGY 300

  Fly   294 VGPGGEVVSDPKVIRMNYLKSW-FIIDLLSCLPYDV------------FNAFDRDEDGIGSLFSA 345
            :..|..|..|.| :..:|:.|. ||.|:::.:|.|:            |..|
  Fly   301 LEQGLMVYDDRK-LACHYVHSRDFIFDMIALIPLDLLQLKMGTHPLLRFTRF------------- 351

  Fly   346 LKVVRLLRLGRVVRKLDRYLEYGAAMLILLLCFYMLVAHWLACIWYSIGRSDADNGIQYSWLWKL 410
            .||.|.:|...:|.  .|.:......::.|:...:::|||..|.::.:..::   |.|..|::
  Fly   352 FKVYRSVRFYYIVE--SRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAE---GFQGDWVY-- 409

  Fly   411 ANVTQSPYSYIWSNDTGPELVNGPSRKSMYVTALYFTMTCMTSVGFGNVAAETDNEKVFTICMMI 475
                  ||.        |......:||  |:.:||::...:|::| .....||:.|.:|||...:
  Fly   410 ------PYR--------PGDYATLTRK--YLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYL 457

  Fly   476 IAALLYATIFGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERVM---DYVVSTWAMT 537
            |...::|||.|.|..:|....:...::..:|:..:.:|:.|:||..:..||:   ||..|...:.
  Fly   458 IGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQ 522

  Fly   538 KGLDTEKVLNYCPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFMMSHSAPGDLLYHTG 602
            .|.|....|...|..:|.::.:|:|..|..:...|:......|..|.:........|||.:...|
  Fly   523 GGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKG 587

  Fly   603 ESIDSLCFIVTGSLEVIQD-DEVVAILGKGDVFGD-QFWKDSAVGQSAANVRALTYCDLHAIKRD 665
            |....:..|..|.|||:.: .:|:..:..||.||: .......:.:..|:||::.|.:|.::.|:
  Fly   588 EVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSRE 652

  Fly   666 KLLEVLDFYSAFANSFARNLVLTYNLRH----RLIFRKVADVKREKELAERRKNEP--------- 717
            .:|..:..|..     |:.::.|...:.    |.:.:|.|..:.:||.|......|
  Fly   653 DVLAAMKDYPD-----AQEILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQG 712

  Fly   718 ---QLPQNQDHLVRKIFSKFRRTPQVQAGSKELVGGSGQSDVEKGDGEVERTKL------PAKLT 773
               |...:::...:||..|.:...:   |.:.::..|..|  .|.|..:|...|      .:|:.
  Fly   713 QVHQSDSSENSASKKIVDKLKHDVK---GFRNVLKKSRTS--RKSDESLEMQPLHNTSPRGSKIL 772

  Fly   774 LTEDARILS------TAAAPSP--SPSPSP-SSGPPSARSTRASKWGRLLGSSSVDSA--SDTSA 827
            |...:|:.|      :|.|...  ..:||| .:|.|..:..|..|..:.....:|.|.  ..:..
  Fly   773 LKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQDREERAVKSTPPQKSPP 837

  Fly   828 KVAVSRSLSARESLRES--------------TAQARQSSTSSSNGGQGNKVFPKAP--------- 869
            ...|:.:||.:||::|.              ..|.:..:...:|..:...|....|
  Fly   838 HSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDS 902

  Fly   870 KLQASQATLARQDTIDEGGEVDSSPPSRDSRVV-------------IE----GAAVSSATVGPS- 916
            ...||||..:...  ..||.:..|.|.:...|.             |:    |...:|::.|||
  Fly   903 HFAASQAGASHPG--PNGGAIGISAPGQSLTVAQIKPIMKVSFKQKIQQMQGGGGGASSSPGPST 965

  Fly   917 -------PPV--------ATTSS--AAAGAGVSGGPGSGGTVVAIVTKADRNLALERERQIEMAS 964
                   ||.        ||:..  ||||.|:..|..||   :|.::|          |.::..|
  Fly   966 GAIAKKEPPKSLALVAKHATSEDPVAAAGLGLGSGSSSG---IATISK----------RVVKPQS 1017

  Fly   965 SRATTSDTYDTGLRETPPTLAQRDLIATVL-----------------------------DMKVDV 1000
            .|..|....||....||.....:..:||::                             .|:...
  Fly  1018 HRMATPLQSDTDTDGTPIKPWSKLKLATLMSSSYTSLTNCSPDDLASPLKNYSLSNIPQQMESHT 1082

  Fly  1001 R----------------------------------------------------------LELQRM 1007
            |                                                          |.||:.
  Fly  1083 RPRHHSARSSSRSPRHGHHHHHHHGHHQHGQLQGPSSTCTNGSTTSQVNQVTASAKRDCLRLQKP 1147

  Fly  1008 QQRI--GRIEDLLGELVKRLAPGAGSGGNAPDNSSGQTTPGDEICA------------------- 1051
            :|.:  |.:.:|           .|:|......|....:|  |.|.
  Fly  1148 EQHLPDGELTEL-----------GGNGRRKLYQSVFDLSP--EYCGLPFVKRLKILNERQKLAEL 1199

  Fly  1052 -----------GCGAGGGGTPTTQAPPTSAV------TSPVDTVI------TISSPGASGSGSGT 1093
                       .|...|   |.::.|.|.::      ||.:.:..      |.||...|.:.|.:
  Fly  1200 ERALQTRSFSLDCSKSG---PDSKVPITESLYRCYSDTSGIYSQFLSTYESTTSSTSISTNTSAS 1261

  Fly  1094 GAGAGSAVAGAGGAGL---------LNPGATVVSSAGGNGLGPLMLKKRRSKS--RKAPAPPKQT 1147
            .:.:.||.|.|..:..         |:|.:...            :::|:.||  :|......|.
  Fly  1262 ASASASASASASDSNSRQLQYVPLPLSPESNET------------MERRKLKSILKKLQMGGGQQ 1314

  Fly  1148 LASTAGTATAAPAGVAGSGMTSSAPASADQQQQ---HQSTADQSPTTPGAELLHLRLLEEDFTAA 1209
            ..:..||.|.|.| |.|:|  |...:||.|:.|   .:.|.:..|.:...|       |..|..|
  Fly  1315 EEAGPGTGTGAGA-VMGTG--SKVNSSASQKGQGLPAEPTLEGPPASAKEE-------ESPFGGA 1369

  Fly  1210 QLPSTSSGGAGGGGGSGSGATPTTPPPTTAGGSGSGTPTSTTATTT--PTGSGTA 1262
            ....:.:...|.|.|:||         .:..|:||||...::|.::  |:.:|.:
  Fly  1370 AAIGSVNNACGNGNGNGS---------VSGNGNGSGTVNDSSANSSSHPSNNGNS 1415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eag	NP_001036275.1	PAS_9	28..155	CDD:290162	8/43 (19%)
		PAS	40..153	CDD:238075	7/41 (17%)
		Ion_trans	254..499	CDD:278921	59/257 (23%)
		Ion_trans_2	<440..494	CDD:285168	18/53 (34%)
		Crp	565..>702	CDD:223736	31/142 (22%)
		CAP_ED	571..682	CDD:237999	26/112 (23%)
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	64/303 (21%)
		Ion_trans_2	382..476	CDD:285168	30/115 (26%)
		Crp	550..>680	CDD:223736	29/134 (22%)
		CAP_ED	556..668	CDD:237999	27/116 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445381
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2706
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840