DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eag and KCNH5

DIOPT Version :9

Sequence 1:	NP_001036275.1	Gene:	eag / 32428	FlyBaseID:	FBgn0000535	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_647479.2	Gene:	KCNH5 / 27133	HGNCID:	6254	Length:	988	Species:	Homo sapiens

Alignment Length:	1120	Identity:	546/1120 - (48%)
Similarity:	710/1120 - (63%)	Gaps:	180/1120 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPGGRRGLVAPQNTFLENIIRRSNSQPDSSFLLANAQIVDFPIVYCNESFCKISGYNRAEVMQKS 65
            ||||:||||||||||||||:|||:   :|||||.||||||:|:||.|:.|||:|||:||:|||||
Human     1 MPGGKRGLVAPQNTFLENIVRRSS---ESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

  Fly    66 CRYVCGFMYGELTDKETVGRLEYTLENQQQDQFEILLYKKNNLQCGCALSQFGKAQTQETPLWLL 130
            .  .|.|||||||||:|:.::..|.:|.:.:.||:||||||                 .||:|..
Human    63 S--TCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKN-----------------RTPVWFY 108

  Fly   131 LQVAPIRNERDLVVLFLLTFRDITALKQPIDSEDTKGVLGLSKFAKLARSVTRSRQFSAHLPTLK 195
            :|:||||||.:.|||||.||:|||..||||:.:.||   |.:|||:|.|::|.||.....|..:.
Human   109 MQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTK---GWTKFARLTRALTNSRSVLQQLTPMN 170

  Fly   196 DPT---KQSNLAHMMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPYN 257
            ...   |.|.||.::.|.:||:|||:||||||||||:|||||||..||||||.||||||||||||
Human   171 KTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYN 235

  Fly   258 VAFKNKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYLKSWFIIDLLS 322
            |:||.| ..:::.||:||:|||||.:|||||||||||||||||:||||:|||||||:||:|||||
Human   236 VSFKTK-QNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299

  Fly   323 CLPYDVFNAFDRDEDGIGSLFSALKVVRLLRLGRVVRKLDRYLEYGAAMLILLLCFYMLVAHWLA 387
            |||||:.|||:..::||.||||:||||||||||||.||||.|||||||:|:||:|.:.|||||||
Human   300 CLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLA 364

  Fly   388 CIWYSIGR----SDADNGIQY-SWLWKLANVTQSPYSY-----IWSNDTGPELVNGPSRKSMYVT 442
            |||||||.    .:..|.||. |||::||....:||.|     ||.        .|||:.|:||:
Human   365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE--------GGPSKDSLYVS 421

  Fly   443 ALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYATIFGHVTTIIQQMTSATAKYHDMLN 507
            :||||||.:|::||||:|..||.||:|::.||::.:||||||||:||||.|||.:.|.:||:|||
Human   422 SLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLN 486

  Fly   508 NVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDTEKVLNYCPKDMKADICVHLNRKVFNEHPAF 572
            |||:|:||::|||.||||||||:||||:|:||:||||||:.|||||:||||||||||||||||||
Human   487 NVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAF 551

  Fly   573 RLASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCFIVTGSLEVIQDDEVVAILGKGDVFGDQ 637
            ||||||||||||:.|...|.|||||:||.|||:|:|||:|:|||||||||||||||||||||||.
Human   552 RLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDI 616

  Fly   638 FWKDSAVGQSAANVRALTYCDLHAIKRDKLLEVLDFYSAFANSFARNLVLTYNLRHRLIFRKVAD 702
            |||::.:..:.||||||||||||.|||:.||:|||||:||||||:|||.||.|||.|:||||::|
Human   617 FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISD 681

  Fly   703 VKREKELAERRKNEPQLPQNQDHLVRKIFSKFRRTPQVQAGSKELVG-GSGQSDVEKGDGEVERT 766
            ||:|:|...|:|||..|....||.|||:|.||::       .|||.. ||.|.|.|:...:||
Human   682 VKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQ-------QKELRNQGSTQGDPERNQLQVE-- 737

  Fly   767 KLPAKLTLTEDARILSTAAAPSPSPSPSPSSGPPSARSTRASKWGRLLGSSSVDSASDTSAKVAV 831
                       :|.|...|:                          :.|:|.|..:..|..:.::
Human   738 -----------SRSLQNGAS--------------------------ITGTSVVTVSQITPIQTSL 765

  Fly   832 SRSLSARESLRESTAQARQSSTSSSNGGQGNKVF----PKAPKLQASQATLARQDTI-------- 884
            : .:...|||:::.   |.:.....|||...|..    |...|....:..|..::.:
Human   766 A-YVKTSESLKQNN---RDAMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKE 826

  Fly   885 --------DEGGEVDSSPPSRDSRVVIEGAAVSSATVGPSPPVATTSSAAAGAGVSGGPGSGGTV 941
                    :..|.:...|.|.||.        :|.|   ..|:..|.|..:|
Human   827 DWNNVTKAESMGLLSEDPKSSDSE--------NSVT---KNPLRKTDSCDSG------------- 867

  Fly   942 VAIVTKADRNL--ALERERQIEMASSRATTSDTYDTGLRETPPTLAQRDLIATVLDMKVDVRLEL 1004
               :||:|..|  |.|....:|.:..:|.....:        ..:.::.|..|:.::|.:::.::
Human   868 ---ITKSDLRLDKAGEARSPLEHSPIQADAKHPF--------YPIPEQALQTTLQEVKHELKEDI 921

  Fly  1005 QRMQQRIGRIEDLLGELVKRLAPGAGSGGNAPDNSSGQTTPGDEICAGCGAGGGGTPTTQAPPTS 1069
            |.:..|:..:|..:.|::|.|     |..:.|..||                    |.:|.|...
Human   922 QLLSCRMTALEKQVAEILKIL-----SEKSVPQASS--------------------PKSQMPLQV 961

  Fly  1070 AVTSPVDTVITISSP 1084
            ....|...:.::|.|
Human   962 PPQIPCQDIFSVSRP 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eag	NP_001036275.1	PAS_9	28..155	CDD:290162	68/126 (54%)
		PAS	40..153	CDD:238075	56/112 (50%)
		Ion_trans	254..499	CDD:278921	160/254 (63%)
		Ion_trans_2	<440..494	CDD:285168	33/53 (62%)
		Crp	565..>702	CDD:223736	104/136 (76%)
		CAP_ED	571..682	CDD:237999	84/110 (76%)
KCNH5	NP_647479.2	PAS_9	39..132	CDD:404329	56/111 (50%)
		PLN03192	217..>616	CDD:215625	284/407 (70%)
		Selectivity filter. /evidence=ECO:0000250	432..437		2/4 (50%)
		Crp	544..725	CDD:223736	126/187 (67%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		7/10 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..742		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..890		18/78 (23%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	969..988		2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I1016
eggNOG	1	0.900	-	-		E1_COG2202
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	973	1.000	Inparanoid score	I317
Isobase	1	0.950	-	0	Normalized mean entropy	S3045
OMA	1	1.010	-	-		QHG48089
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm40965
orthoMCL	1	0.900	-	-		OOG6_104814
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3522
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820