DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eag and Kcnh5

DIOPT Version :9

Sequence 1:	NP_001036275.1	Gene:	eag / 32428	FlyBaseID:	FBgn0000535	Length:	1270	Species:	Drosophila melanogaster
Sequence 2:	NP_766393.2	Gene:	Kcnh5 / 238271	MGIID:	3584508	Length:	988	Species:	Mus musculus

Alignment Length:	1124	Identity:	552/1124 - (49%)
Similarity:	718/1124 - (63%)	Gaps:	188/1124 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPGGRRGLVAPQNTFLENIIRRSNSQPDSSFLLANAQIVDFPIVYCNESFCKISGYNRAEVMQKS 65
            ||||:||||||||||||||:|||:   :|||||.||||||:|:||.|:.|||:|||:||:|||||
Mouse     1 MPGGKRGLVAPQNTFLENIVRRSS---ESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

  Fly    66 CRYVCGFMYGELTDKETVGRLEYTLENQQQDQFEILLYKKNNLQCGCALSQFGKAQTQETPLWLL 130
            .  .|.|||||||||:|:.::..|.:|.:.:.||:||||||                 .||:|..
Mouse    63 S--TCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKN-----------------RTPVWFY 108

  Fly   131 LQVAPIRNERDLVVLFLLTFRDITALKQPIDSEDTKGVLGLSKFAKLARSVTRSRQFSAHL-PTL 194
            :|:||||||.:.|||||.||:|||..||||:.:.||   |.:|||:|.|::|.||.....| |..
Mouse   109 MQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTK---GWTKFARLTRALTNSRSVLQQLTPMN 170

  Fly   195 KDPT--KQSNLAHMMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPYN 257
            |..|  |.|.||.::.|.:||:|||:||||||||||:|||||||..||||||.||||||||||||
Mouse   171 KTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYN 235

  Fly   258 VAFKNKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYLKSWFIIDLLS 322
            |:||.| ..:::.||:||:|||||.:|||||||||||||||||:||||:|||||||:||:|||||
Mouse   236 VSFKTK-QNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299

  Fly   323 CLPYDVFNAFDRDEDGIGSLFSALKVVRLLRLGRVVRKLDRYLEYGAAMLILLLCFYMLVAHWLA 387
            |||||:.|||:..::||.||||:||||||||||||.||||.|||||||:|:||:|.:.|||||||
Mouse   300 CLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLA 364

  Fly   388 CIWYSIGR----SDADNGIQY-SWLWKLANVTQSPYSY-----IWSNDTGPELVNGPSRKSMYVT 442
            |||||||.    .:..|.||. |||::||....:||.|     ||.        .|||:.|:||:
Mouse   365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE--------GGPSKDSLYVS 421

  Fly   443 ALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYATIFGHVTTIIQQMTSATAKYHDMLN 507
            :||||||.:|::||||:|..||.||:|::.||::.:||||||||:||||.|||.:.|.:||:|||
Mouse   422 SLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLN 486

  Fly   508 NVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDTEKVLNYCPKDMKADICVHLNRKVFNEHPAF 572
            |||:|:||::|||.||||||||:||||:|:||:||||||:.|||||:||||||||||||||||||
Mouse   487 NVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAF 551

  Fly   573 RLASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCFIVTGSLEVIQDDEVVAILGKGDVFGDQ 637
            ||||||||||||:.|...|.|||||:||.|||:|:|||:|:||||||||:||||||||||||||.
Mouse   552 RLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDI 616

  Fly   638 FWKDSAVGQSAANVRALTYCDLHAIKRDKLLEVLDFYSAFANSFARNLVLTYNLRHRLIFRKVAD 702
            |||::.:..:.||||||||||||.|||:.||:|||||:||||||:|||.||.|||.|:||||::|
Mouse   617 FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISD 681

  Fly   703 VKREKELAERRKNEPQLPQNQDHLVRKIFSKFRRTPQVQAGSKEL-VGGSGQSDVEKGDGEVERT 766
            ||:|:|...|:|||..|....||.|||:|.||::       .||| :.||.|||.|:...:||
Mouse   682 VKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQ-------QKELRIQGSAQSDPERSQLQVE-- 737

  Fly   767 KLPAKLTLTEDARILSTAAAPSPSPSPSPSSGPPSARSTRASKWGRLLGSSSVDSASDTSAKVAV 831
                       :|.|...|:                          :.|:|.|..:..|..:.::
Mouse   738 -----------SRPLQNGAS--------------------------ITGTSVVTVSQITPIQTSL 765

  Fly   832 SRSLSARESLRESTAQARQSSTSSSNGGQGNKVFPKAPKLQAS--------------QATLARQD 882
            : .:...|||:::.   |.:.....|||    ..||..|:.:.              :..:..|:
Mouse   766 A-YVKTSESLKQNN---RDAMELKPNGG----AEPKCLKVNSPIRMKNGNGKGWLRLKNNMGAQE 822

  Fly   883 TIDEG----------GEVDSSPPSRDSRVVIEGAAVSSATVGPSPPVATTSSAAAGAGVSGGPGS 937
            ...|.          |.:...|...||.        :|.|   ..|:..|.|..:|
Mouse   823 EKKEDWNNVTKAESMGLLSEDPKGSDSE--------NSVT---KNPLRKTDSCDSG--------- 867

  Fly   938 GGTVVAIVTKADRNL--ALERERQIEMASSRATTSDTYDTGLRETPPTLAQRDLIATVLDMKVDV 1000
                   :||:|..|  |.|....:|.:.|:|....::        ..:.::.|..|:.::|.::
Mouse   868 -------ITKSDLRLDKAGEARSPLEHSPSQADVKHSF--------YPIPEQALQTTLQEVKHEL 917

  Fly  1001 RLELQRMQQRIGRIEDLLGELVKRLAPGAGSGGNAPDNSSGQTTPGDEICAGCGAGGGGTPTTQA 1065
            :.::|.:..|:..:|..:.|::|.|     |..:.|..||    |..:|            ..|.
Mouse   918 KEDIQLLSCRMTALEKQVAEILKLL-----SEKSVPQTSS----PKPQI------------PLQV 961

  Fly  1066 PPTSAVTSPVDTVITISSP 1084
            ||    ..|...:.::|.|
Mouse   962 PP----QIPCQDIFSVSRP 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eag	NP_001036275.1	PAS_9	28..155	CDD:290162	68/126 (54%)
		PAS	40..153	CDD:238075	56/112 (50%)
		Ion_trans	254..499	CDD:278921	160/254 (63%)
		Ion_trans_2	<440..494	CDD:285168	33/53 (62%)
		Crp	565..>702	CDD:223736	103/136 (76%)
		CAP_ED	571..682	CDD:237999	83/110 (75%)
Kcnh5	NP_766393.2	PAS	37..131	CDD:238075	56/112 (50%)
		PAS_3	40..127	CDD:285623	52/105 (50%)
		Ion_trans	232..479	CDD:278921	160/255 (63%)
		Ion_trans_2	<419..473	CDD:285168	33/53 (62%)
		Selectivity filter. /evidence=ECO:0000250	432..437		2/4 (50%)
		Crp	544..723	CDD:223736	124/185 (67%)
		CAP_ED	550..660	CDD:237999	82/109 (75%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		7/10 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..741		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..893		18/81 (22%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948		9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I1005
eggNOG	1	0.900	-	-		E1_COG2202
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	973	1.000	Inparanoid score	I317
Isobase	1	0.950	-	0	Normalized mean entropy	S3045
OMA	1	1.010	-	-		QHG48089
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm43035
orthoMCL	1	0.900	-	-		OOG6_104814
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3522
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820