Protein Alignment eag and Kcnh1

DIOPT Version :10

• Sequence 1: NP_001036275.1
• Gene: eag / 32428
• FlyBaseID: FBgn0000535
• Length: 1270
• Species: Drosophila melanogaster
• Sequence 2: NP_034730.1
• Gene: Kcnh1 / 16510
• MGIID: 1341721
• Length: 989
• Species: Mus musculus
• Alignment Length: 1111
• Identity: 534/1111 - (48%)
• Similarity: 691/1111 - (62%)
• Gaps: 203/1111 - (18%)

  Fly     1 MPGGRRGLVAPQNTFLENIIRRSNSQPDSSFLLANAQIVDFPIVYCNESFCKISGYNRAEVMQKS 65
            |.|||||||||||||||||:||||   |::|:|.||||||:||||.|:.|||:|||:||||||||
Mouse     3 MAGGRRGLVAPQNTFLENIVRRSN---DTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

  Fly    66 CRYVCGFMYGELTDKETVGRLEYTLENQQQDQFEILLYKKNNLQCGCALSQFGKAQTQETPLWLL 130
            .  .|.|||||||||:||.::..|.||.:.:.||||:||||                 .||:|..
Mouse    65 S--ACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKN-----------------RTPVWFF 110

  Fly   131 LQVAPIRNERDLVVLFLLTFRDITALKQPIDSEDTKGVLGLSKFAKLARSVTRSR----QFSAHL 191
            :::||||||:|.|||||.||.||||.||||:.:..|   |..|||:|.|::|.||    |.:..:
Mouse   111 VKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCK---GWGKFARLTRALTSSRGVLQQLAPSV 172

  Fly   192 PTLKDPTKQSNLAHMMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPY 256
            ...::..|.|.||.::.|.:||:|||:||||||||||:||||.||..|||:||.|||||||:|||
Mouse   173 QKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPY 237

  Fly   257 NVAFKNKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYLKSWFIIDLL 321
            ||:||.: ..:|:.|||||||||||.:|||||||||||||.|||:||||:|||||||:||:||||
Mouse   238 NVSFKTR-QNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLL 301

  Fly   322 SCLPYDVFNAFD---------------------------RDEDGIGSLFSALKVVRLLRLGRVVR 359
            |||||||.|||:                           |:..||.||||:||||||||||||.|
Mouse   302 SCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVAR 366

  Fly   360 KLDRYLEYGAAMLILLLCFYMLVAHWLACIWYSIG-----RSDADNGIQYSWLWKLANVTQSPYS 419
            |||.|:|||||:|:||:|.:.|.|||:||||||||     ..|.......|||::||....:||.
Mouse   367 KLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQ 431

  Fly   420 YIWSNDTGP-ELVNGPSRKSMYVTALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYAT 483
            :   |.:|. :...|||:.|:|:::||||||.:|||||||:|..||.||:|.:.:|:|.:|||||
Mouse   432 F---NGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYAT 493

  Fly   484 IFGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDTEKVLNY 548
            |||:||||.|||.:.|.:||:|||:||:|:||::|||.||||||||:||||:|::|:||||||..
Mouse   494 IFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQI 558

  Fly   549 CPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCFIVT 613
            |||||:||||||||||||.||||||||||||||||||.|...|.|||||:||.|||:|||||:|:
Mouse   559 CPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVS 623

  Fly   614 GSLEVIQDDEVVAILGKGDVFGDQFWKDSAVGQSAANVRALTYCDLHAIKRDKLLEVLDFYSAFA 678
            |||||||||||||||||||||||.|||::.:.||.||||||||||||.||||.|.:||:||:||:
Mouse   624 GSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFS 688

  Fly   679 NSFARNLVLTYNLRHRLIFRKVADVKREKELAERRKNEPQLPQNQDHLVRKIFSKFRRTPQVQAG 743
            :||:|||:||||||.|::|||::|||||:|...:||||..|....||.||::|.:||:..:.:..
Mouse   689 HSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLA 753

  Fly   744 SKELVGGS--GQSDVEKGDGEVERTKLPAKLTLTEDARILSTAAAPSPSPSPSPSS--------- 797
            ::.  ||.  ...|||||:...:.|.....|.......:..:.|.|....:.:.|:
Mouse   754 AER--GGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAATTSTMSDHAKLHA 816

  Fly   798 ------GPPSARSTRASK--WGRLLGSSSVDSASDTSAKVAVSRSLSARESLRESTAQARQSSTS 854
                  ||.:.....|.:  |.|.  ..:.....|.: ||:.:.|:   |:|.|.|
Mouse   817 PGSECLGPKAVSCDPAKRKGWARF--KDACGKGEDWN-KVSKAESM---ETLPERT--------- 866

  Fly   855 SSNGGQGNKVFPKAPKLQASQATLARQDTIDEGGEVDSSPPSRDSRVVIEGAAVSSATVGPSPPV 919
                        |||    .:|||.:.|:.|.|
Mouse   867 ------------KAP----GEATLKKTDSCDSG-------------------------------- 883

  Fly   920 ATTSSAAAGAGVSGGPGSGGTVVAIVTKADRNLALERERQIEMASSRATTSDTYDTGLRETPPTL 984
                                     :||:|  |.|:...:......|:              |.|
Mouse   884 -------------------------ITKSD--LRLDNVGETRSPQDRS--------------PIL 907

  Fly   985 A----------QRDLIATVLDMKVDVRLELQRMQQRIGRIEDLLGELVKRLAPGAGSGGNAPDNS 1039
            |          ::.|.||||::|.:::.:::.:..::..||..|.|:: |:....|| ..:|..:
Mouse   908 AEVKHSFYPIPEQTLQATVLEVKYELKEDIKALNAKMTSIEKQLSEIL-RILMSRGS-AQSPQET 970

  Fly  1040 SGQTTP 1045
            ...:.|
Mouse   971 GEISRP 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eag	NP_001036275.1	PAS_9	40..155	CDD:463873	62/114 (54%)
		Ion_trans	238..499	CDD:459842	170/293 (58%)
		CAP_ED	571..682	CDD:237999	85/110 (77%)
Kcnh1	NP_034730.1	PAS_9	41..135	CDD:463873	61/112 (54%)
		Required for phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250|UniProtKB:O95259	151..162		5/10 (50%)
		PLN03192	220..>647	CDD:215625	279/430 (65%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472	463..468		4/4 (100%)
		PRK11753	608..>712	CDD:236969	77/103 (75%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:27618660	673..770		49/98 (50%)
		Interaction with cyclic nucleotide-binding pocket. /evidence=ECO:0000269|PubMed:22732247	699..701		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..905		20/148 (14%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250|UniProtKB:Q63472	924..964		12/41 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	961..989		4/17 (24%)