DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and caiC

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_414579.4	Gene:	caiC / 944886	ECOCYCID:	EG11558	Length:	517	Species:	Escherichia coli

Alignment Length:	537	Identity:	135/537 - (25%)
Similarity:	228/537 - (42%)	Gaps:	56/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 VWRDFKK-WERRTAAVCVITD---RQYTFAQM-----RDASAAFAVRLQTKFNLQKPDVLAICLP 136
            :|.|... :..:||.:|..:.   .:|::.::     |.|:..:.:      .::|.|.:|:.|.
E. coli    12 MWDDLADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTL------GIRKGDKVALHLD 70

  Fly   137 NLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQ-----ASKLV 196
            |.||:.....|..:.|..:..:|.....:|.|..|..|.|..||.:...:....|     |::|
E. coli    71 NCPEFIFCWFGLAKIGAIMVPINARLLCEESAWILQNSQACLLVTSAQFYPMYQQIQQEDATQL- 134

  Fly   197 GRQIPIAVVRTSAEEALPEGAIDFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGV 261
             |.|.:..|...|::.:       |..|..:|.:...|......|.||...:.|:||||..||||
E. coli   135 -RHICLTDVALPADDGV-------SSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGV 191

  Fly   262 MLSHNNI--TSNCEQVQASLPLDLMGPQNTLPGVLPFFHIYGLTVVMLSKLGQGCRLATMPCFKP 324
            :::|.|:  .......|.:|..|     :....|:|.|||.......::....|.....:..:..
E. coli   192 VITHYNLRFAGYYSAWQCALRDD-----DVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSA 251

  Fly   325 DDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLKVVMSGAAPIGQHDVERFLNKFPNTV 389
            ..|...:.||:.::...:|.:...::..|....:....|:.||. ...:.:.:.:.|..:| ...
E. coli   252 RAFWGQVQKYRATVTECIPMMIRTLMVQPPSANDQQHRLREVMF-YLNLSEQEKDAFCERF-GVR 314

  Fly   390 FKQGYGMTEASPVVLLTPEGNK-VYASTGVLPASTEAKI-----VPLDGSDAKGVGPRTTGELCV 448
            ....|||||....::....|:| .:.|.|.:....||:|     .||...:        .||:|:
E. coli   315 LLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFCYEAEIRDDHNRPLPAGE--------IGEICI 371

  Fly   449 R---GPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPAEL 510
            :   |..:...|..|.:|.........||.:||..:.||:..||..||...:||..|..|...||
E. coli   372 KGIPGKTIFKEYFLNPQATAKVLEADGWLHTGDTGYRDEEDFFYFVDRRCNMIKRGGENVSCVEL 436

  Fly   511 EAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLEGGVIFV 575
            |.::..||||.:..|.||......||.:|.|||.:||..|.||...:..:.:|.: |:...:...
E. coli   437 ENIIAAHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFRFCEQNMAKF-KVPSYLEIR 500

  Fly   576 DEVPKNPTGKILRRELK 592
            .::|:|.:|||:|:.||
E. coli   501 KDLPRNCSGKIIRKNLK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	135/537 (25%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	126/511 (25%)
caiC	NP_414579.4	caiC	1..517	CDD:181195	133/535 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	5	4.810