DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and PCS60

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_009781.3	Gene:	PCS60 / 852523	SGDID:	S000000426	Length:	543	Species:	Saccharomyces cerevisiae

Alignment Length:	608	Identity:	175/608 - (28%)
Similarity:	264/608 - (43%)	Gaps:	105/608 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SAATRSITTNRRQRTTSTASAQRERTQSVSETDKFLHY---SPEDGYYKTSPFDPVTIPNVPLHE 79
            ||||.:.:.|      .|.|........|.|||..:.|   |...|:::|.    .|.||.||:.
Yeast     3 SAATVTASFN------DTFSVSDNVAVIVPETDTQVTYRDLSHMVGHFQTM----FTNPNSPLYG 57

  Fly    80 YVWRDFKKWERRTAAVCVITDRQYTFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIA 144
            .|:|.                                            |.:||.:.|..|:.:|
Yeast    58 AVFRQ--------------------------------------------DTVAISMRNGLEFIVA 78

  Fly   145 TLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLV---GTVSGFATLSQASKLVGR-------- 198
            .|||.........:||.|...|....|....:|.:.   ||     |..|:|:::..
Yeast    79 FLGATMDAKIGAPLNPNYKEKEFNFYLNDLKSKAICVPKGT-----TKLQSSEILKSASTFGCFI 138

  Fly   199 -QIPIAVVRTSAEEAL--PEG---AIDFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGL 257
             ::.....|...|..:  ||.   .:.:..|.:.:.|....:|.|..|.:.|:..:..:||||..
Yeast   139 VELAFDATRFRVEYDIYSPEDNYKRVIYRSLNNAKFVNTNPVKFPGFARSSDVALILHTSGTTST 203

  Fly   258 PKGVMLSHNNI---TSNCEQVQASLPLDLMGPQNTLPGVLPFFHIYGLTVVMLSKLGQGCRLATM 319
            ||.|.|.|.||   |.|........|||....      |:|.||::||..|:||.......:...
Yeast   204 PKTVPLLHLNIVRSTLNIANTYKLTPLDRSYV------VMPLFHVHGLIGVLLSTFRTQGSVVVP 262

  Fly   320 PCFKPDDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLKVV---MSGAAPIGQHDVERF 381
            ..|.|..|.....||..:..:.||.|::.|:|.||  ....||::.:   .|..||...|.:|:
Yeast   263 DGFHPKLFWDQFVKYNCNWFSCVPTISMIMLNMPK--PNPFPHIRFIRSCSSALAPATFHKLEK- 324

  Fly   382 LNKFPNTVFKQGYGMTEASPVVLLT--PEGNKVYASTGVLPASTEAKIVPLDGSDAKGVGPRTTG 444
              :| |....:.|.|||||..:...  |.|.:...:.|.....|   :|.||.:| ..:.|...|
Yeast   325 --EF-NAPVLEAYAMTEASHQMTSNNLPPGKRKPGTVGQPQGVT---VVILDDND-NVLPPGKVG 382

  Fly   445 ELCVRGPQVMAGYLNNDEANQVTFYP-GNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPA 508
            |:.:||..|..||.||.:||:..|.. .|:.|:||..::|.:|...:|.|:||||...|.::.|.
Yeast   383 EVSIRGENVTLGYANNPKANKENFTKRENYFRTGDQGYFDPEGFLVLTGRIKELINRGGEKISPI 447

  Fly   509 ELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLEGGVI 573
            ||:.::..||||.||..||:|.:..|:..:|.:||::|||.:.||:..::.:.:|.: |:...|.
Yeast   448 ELDGIMLSHPKIDEAVAFGVPDDMYGQVVQAAIVLKKGEKMTYEELVNFLKKHLASF-KIPTKVY 511

  Fly   574 FVDEVPKNPTGKILRRELKEKFS 596
            |||::||..||||.||.:.|.|:
Yeast   512 FVDKLPKTATGKIQRRVIAETFA 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	155/543 (29%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	148/513 (29%)
PCS60	NP_009781.3	FACL_fum10p_like	18..531	CDD:341249	166/582 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I1304
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I924
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46937
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.740