DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and 4CL2

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_188761.1	Gene:	4CL2 / 821678	AraportID:	AT3G21240	Length:	556	Species:	Arabidopsis thaliana

Alignment Length:	540	Identity:	203/540 - (37%)
Similarity:	301/540 - (55%)	Gaps:	29/540 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VTIPN-VPLHEYVWRDFKKWERRTAAVCVI---TDRQYTFAQMRDASAAFAVRLQTKFNLQKPDV 130
            :.||| :|||:|::.:..::   .|..|:|   |...||:|.:...|...|..|. ...:::.||
plant    30 IYIPNHLPLHDYIFENISEF---AAKPCLINGPTGEVYTYADVHVTSRKLAAGLH-NLGVKQHDV 90

  Fly   131 LAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQASKL 195
            :.|.|||.||..:..|.|...|...|:.||.:||.||::|...|.||.:| |.|.:     ..|:
plant    91 VMILLPNSPEVVLTFLAASFIGAITTSANPFFTPAEISKQAKASAAKLIV-TQSRY-----VDKI 149

  Fly   196 VGRQIPIAVVRTSAEEALPEGAIDFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKG 260
            ...|....::.|:..:|:||..:.|||||.::..|.:.:  |::.|.:|:|.|||||||||||||
plant   150 KNLQNDGVLIVTTDSDAIPENCLRFSELTQSEEPRVDSI--PEKISPEDVVALPFSSGTTGLPKG 212

  Fly   261 VMLSHNN-ITSNCEQVQASLPLDLMGPQNTLPGVLPFFHIYGLTVVMLSKLGQGCRLATMPCFKP 324
            |||:|.. :||..:||....|.......:.:..|||.||||.|..:||..|..|..:..||.|:.
plant   213 VMLTHKGLVTSVAQQVDGENPNLYFNRDDVILCVLPMFHIYALNSIMLCSLRVGATILIMPKFEI 277

  Fly   325 DDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLKVVMSGAAPIGQHDVERFLNKFPNTV 389
            ...:..:.:.:.::..:||||.|.:...|:..:.....:::|.|||||:|:...:....||||..
plant   278 TLLLEQIQRCKVTVAMVVPPIVLAIAKSPETEKYDLSSVRMVKSGAAPLGKELEDAISAKFPNAK 342

  Fly   390 FKQGYGMTEASPVVLLT------PEGNKVYASTGVLPASTEAKIVPLDGSDAKGVGPRT-TGELC 447
            ..||||||||.||:.::      |...| ..:.|.:..:.|.||:..|..|:.   ||. .||:|
plant   343 LGQGYGMTEAGPVLAMSLGFAKEPFPVK-SGACGTVVRNAEMKILDPDTGDSL---PRNKPGEIC 403

  Fly   448 VRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPAELEA 512
            :||.|:|.||||:..|...|.....||.:|||.|.|:|...:|.||:|||||.|||||.|||||:
plant   404 IRGNQIMKGYLNDPLATASTIDKDGWLHTGDVGFIDDDDELFIVDRLKELIKYKGFQVAPAELES 468

  Fly   513 VLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLEGGVIFVDE 577
            :|..||:|.:.||..:..|..||.|.|.||..:....|.:||..:|:::|..||:: ..|.|.|.
plant   469 LLIGHPEINDVAVVAMKEEDAGEVPVAFVVRSKDSNISEDEIKQFVSKQVVFYKRI-NKVFFTDS 532

  Fly   578 VPKNPTGKILRRELKEKFSD 597
            :||.|:|||||::|:.:.::
plant   533 IPKAPSGKILRKDLRARLAN 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	199/528 (38%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	189/495 (38%)
4CL2	NP_188761.1	PLN02246	14..553	CDD:215137	203/540 (38%)
4CL2	NP_188761.1	4CL	32..546	CDD:213272	202/530 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	70	1.000	Domainoid score	I3393
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80284
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54045
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	1	1.000	-	-		otm2758
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.790