DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and ACSS3

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_078836.1	Gene:	ACSS3 / 79611	HGNCID:	24723	Length:	686	Species:	Homo sapiens

Alignment Length:	714	Identity:	152/714 - (21%)
Similarity:	267/714 - (37%)	Gaps:	182/714 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNPA-AQLLRMRSATAFG------------SAATRSITT--------NRRQRTTSTASAQRERTQ 44
            |.|: .|..::.||...|            .||.|::..        .|..|..|:.|....:|.
Human     1 MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTH 65

  Fly    45 ---SVSETDKFLHYSPED-GYYK------TSPFDPVT------IPNVPLHEYVWRDFKKWERRTA 93
               ||::.::|...:.|. .:||      .:...|.|      :.|: .:..|.|..:..:....
Human    66 FAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNI-CYNAVDRHIENGKGDKI 129

  Fly    94 AV-----CVITDRQYTFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGL 153
            |:     ...|...:|:.::.:..:..|..| .|..::|.|.:.|.:|.:|:.....|.....|.
Human   130 AIIYDSPVTNTKATFTYKEVLEQVSKLAGVL-VKHGIKKGDTVVIYMPMIPQAMYTMLACARIGA 193

  Fly   154 TVTTVNPVYTPDEIARQLTFSGAKFLVGTVSG--------FATLSQASKLVGRQIP--IAVVRTS 208
            ..:.:...:...|::.::.....|.:|....|        :..|.:.:..:|:..|  |.:....
Human   194 IHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRP 258

  Fly   209 AEEALPEGAIDFSELTSTQNVRYEDLKAPKEASADDMV--------FLPFSSGTTGLPKGV---- 261
            ..||:|        |...:::.:::..|  :|.:.|.|        ::.::||||||||||
Human   259 NMEAVP--------LAPGRDLDWDEEMA--KAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPT 313

  Fly   262 ----MLSHNNITSNCEQVQASLPLDLMGPQNTLPGVL--------PFFHIYGLTVVMLSKLGQGC 314
                ::.|.:::|    :....|.::....:.|..|:        |..|  |.|.|:
Human   314 GGYAVMLHWSMSS----IYGLQPGEVWWAASDLGWVVGHSYICYGPLLH--GNTTVL-------- 364

  Fly   315 RLATMPCFKPDDFMRSLDKYQGSILNLVPPIALFMI--NHPKLTQETAP-HLKVVMS---GAAPI 373
                               |:|..:......|.|.:  .|......||| .::.:..   |||..
Human   365 -------------------YEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALG 410

  Fly   374 GQHDVERFLNKFPNTVFKQGYGMTEASPVVLL-----------------TPEGNKVYASTGVL-- 419
            .|:.:.||     .|:|..|    |...|..|                 |..|:.:.||...|
Human   411 KQYSLTRF-----KTLFVAG----ERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGN 466

  Fly   420 ----PASTEAKIVP------LDGSDAKGVGPRTTGELCVR---GPQVMAGYLNNDEANQVTF--- 468
                |.....|.||      ||.:..| :..|..|.:.|:   .|...:|...|.||.:..:
Human   467 SKTPPPGQAGKSVPGYNVMILDDNMQK-LKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEK 530

  Fly   469 YPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPAELEAVLRDHPKILEAAVFGIPHEFN 533
            :|| :..:.|..:.||:|..|:..|:.::|.|.|.::....:|..:..|..:.:.||.|......
Human   531 FPG-YYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLK 594

  Fly   534 GEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLEGGV------IFVDEVPKNPTGKILRREL 591
            |..|.|:.|||:...|:.|::   :.|.|.|.::..|.|      :||.::||..:|||.|..|
Human   595 GHVPLALCVLRKDINATEEQV---LEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	129/601 (21%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	123/568 (22%)
ACSS3	NP_078836.1	PrpE	62..679	CDD:341271	139/653 (21%)
ACSS3	NP_078836.1	Coenzyme A binding. /evidence=ECO:0000250	227..230		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910