DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and acsf2

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001038884.2	Gene:	acsf2 / 751707	ZFINID:	ZDB-GENE-060825-7	Length:	606	Species:	Danio rerio

Alignment Length:	564	Identity:	150/564 - (26%)
Similarity:	240/564 - (42%)	Gaps:	96/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 KKWERRTAAVCVITDRQYTFAQM-RDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATLGAI 149
            :::..|.|.|.|....:.|||:. :|...|.|..|..  .|::.|.|.:..||:.|:.:......
Zfish    77 ERYPDREAMVFVQDGIRKTFAEFYQDVEKAAAGLLAA--GLKRGDRLGMWGPNIYEWVLMQFATA 139

  Fly   150 EAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQAS-------KLVGRQIPIAVVRT 207
            :||:.:..|||.|...|:         :|.:..|...|.:....       .::.:..|
Zfish   140 KAGIILVAVNPAYQLQEV---------EFALRKVQCNAVVCPTKFKSQHYCDMLKQLCP------ 189

  Fly   208 SAEEALPEGAIDFSELTSTQNVRYEDLKAP------------------------KEASADDMVFL 248
            ..|.|.| |.|..|.|.....|...|.:.|                        |:...||.:.:
Zfish   190 EMETASP-GGIKSSRLPDLHTVIVTDSQQPGSFLLKDLMQAGSSQHYQQLQDLQKKLVCDDPINI 253

  Fly   249 PFSSGTTGLPKGVMLSHNNITSNC------------EQVQASLPLDLMGPQNTLPGVLPFFHIYG 301
            .|:|||||.|||..|||:||.:|.            :.|:..||             :|.:|.:|
Zfish   254 QFTSGTTGKPKGATLSHHNIVNNAYFTGMRIGYNWRKNVRICLP-------------VPLYHCFG 305

  Fly   302 LTVVMLSKLGQGCRLA---TMPCFKPDDF-----MRSLDKYQGSILNLVPPIALFMINHPKLTQE 358
                   .:|.|..:|   |...|....:     :|:::|.:.:.:...|.:.:.|:..|.|.:.
Zfish   306 -------SVGGGVIMALYGTTVIFPSTGYDGRANLRAIEKEKCTFVYGTPTMYIDMLGQPDLAKF 363

  Fly   359 TAPHLKVVMSGAAPIGQHDVERFLNKFPNTVFKQGYGMTEASPVVLL---TPEGNKVYASTGVLP 420
            ....::..::..:|.....:.:.||.........|||.||.|||...   .....:...:.|.:.
Zfish   364 DLSSVRGGIAAGSPCPPEVMRKILNVMGIKEMVIGYGTTENSPVTFCGFPVDSAERKIETVGCIS 428

  Fly   421 ASTEAKIVPLDGSDAKGVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDED 485
            ..||||:|  |.:..:.|.....|||.:||..||..|..::|..:.......|.::||:|..|:.
Zfish   429 PHTEAKVV--DPTTGEIVPLGAQGELMIRGYCVMLEYWQDEEKTRECITKDRWYKTGDIASLDQF 491

  Fly   486 GLFYITDRMKELIKVKGFQVPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKAS 550
            ....|..|:|:||...|..:.|||:|..|..|||||||.|.|:..|..||...|.:.|::|::.:
Zfish   492 AYCKIEGRIKDLIIRGGENIYPAEIEQFLHTHPKILEAQVVGVKDERMGEEVCACIRLKEGQECT 556

  Fly   551 AEEISAYVAERVAHYKKLEGGVIFVDEVPKNPTGKILRRELKEK 594
            .|||.||...::||| |:...::||.:.|...||||.:.:|:|:
Zfish   557 VEEIKAYCKGKIAHY-KVPRYILFVQDYPLTITGKIQKHKLRER 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	150/564 (27%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	143/542 (26%)
acsf2	NP_001038884.2	PRK08315	53..606	CDD:236236	150/564 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740