Protein Alignment pdgy and AACS

DIOPT Version :9

• Sequence 1: NP_001188590.1
• Gene: pdgy / 32426
• FlyBaseID: FBgn0027601
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_076417.2
• Gene: AACS / 65985
• HGNCID: 21298
• Length: 672
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 125/633 - (19%)
• Similarity: 205/633 - (32%)
• Gaps: 237/633 - (37%)

  Fly   104 TFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVY---TPD 165
            ||.::|...|.||..:: |..::|.|.:...|||...       |:||.|...::..::   :||
Human   130 TFEELRQEVALFAAAMR-KMGVKKGDRVVGYLPNSEH-------AVEAMLAAASIGAIWSSTSPD 186

  Fly   166 -----------EIARQLTFS-------GAKF-----LVGTVSGFATL---------SQASKLVGR 198
                       :|..:|.||       |.:.     |...|.|...|         |....:...
Human   187 FGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLS 251

  Fly   199 QIPIAV-----VRTSAEEALPEGAIDFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGLP 258
            :||.:|     :.|...|..|:  ::|.:|..:.                 .:|:.|||||||.|
Human   252 KIPNSVFLDDFLATGTSEQAPQ--LEFEQLPFSH-----------------PLFIMFSSGTTGAP 297

  Fly   259 KGVM--------------LSHNNITSNCEQVQASLPLDLMGPQNTLPGVLPFFHIYGLTVVMLSK 309
            |.::              |.|.|:||:          |::....|:..::..:        |:|.
Human   298 KCMVHSAGGTLIQHLKEHLLHGNMTSS----------DILLCYTTVGWMMWNW--------MVSL 344

  Fly   310 LGQGCRLATMPCFKPDDFMRSLDKYQGSILNLVPPIALFMINHPKLT------------QETA-- 360
            |..|..:..               |.||.|...|.:...:::...:|            :|.|
Human   345 LATGAAMVL---------------YDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMK 394

  Fly   361 ---PH----LKVVMSGAAPI-----------------------GQHDVERFL-NKFPNTVFK--- 391
               .|    |..::|..:|:                       |...:..|: :.|...|:|
Human   395 PVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEI 459

  Fly   392 --QGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVPL------DGSD------AKGVGPRT 442
              :..||.    |.....||..|:..:|.|..:......|.      :|:.      :|..|...
Human   460 QARNLGMA----VEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWA 520

  Fly   443 TGELCVRGPQ----VMAGYLNNDEANQVTFYPGNWLRSGDVAFYD--------EDGLF------Y 489
            .|:.|...|:    ||.|      .:..|..| |.:|.|....|:        ||.|.      |
Human   521 HGDYCRINPKTGGIVMLG------RSDGTLNP-NGVRFGSSEIYNIVESFEEVEDSLCVPQYNKY 578

  Fly   490 ITDRMKELIKVKGFQVPPAELEAVLRD---------HPKILEAAVFGIPHEFNGEAPRAIVVLRQ 545
            ..:|:...:|:........:|...:||         |...|.....|||:..||
Human   579 REERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNG----------- 632

  Fly   546 GEKASAEEISAYVAERVAHYKKLEGGVIFVDEVPKNPTGKILRRELKE 593
                  :::...|.:.:|. |.:|.|..|     .||....|.|::.|
Human   633 ------KKVEVAVKQIIAG-KAVEQGGAF-----SNPETLDLYRDIPE 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	125/633 (20%)
		Firefly_Luc_like	99..587	CDD:213279	122/625 (20%)
AACS	NP_076417.2	ac_ac_CoA_syn	16..670	CDD:273507	125/633 (20%)
		AACS	40..663	CDD:213308	122/626 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910