DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and Acsf2

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	150/548 - (27%)
Similarity:	246/548 - (44%)	Gaps:	61/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 KKWERRTAAVCVITDRQYTFAQMRD-----ASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIAT 145
            :::..|.|.|.:..:.:..|||:::     ||...::      .|:|.|.|.:..||...:.:..
  Rat    83 QRFPNREALVIIHENIRLNFAQLKEEVDRAASGLLSI------GLRKGDRLGMWGPNSYAWVLIQ 141

  Fly   146 LGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLV-----GTVSGFATL---------SQASKLV 196
            |...:||:.:.:|||.|...|:...|...|.|.:|     .|...:..|         :|...|.
  Rat   142 LATAQAGIILVSVNPAYQASELEYVLRKVGCKGIVFPKQFKTQQYYNILKQVCPELEKAQPGALK 206

  Fly   197 GRQIPIAVVRTSAEEALPEGAIDFSELTST----QN---VRYEDLKAPKEASADDMVFLPFSSGT 254
            ..::|......|.:..|| |.:...|:.:.    ||   :||..    ...|..|.:.:.|:|||
  Rat   207 SERLPDLTTVISVDAPLP-GTLLLDEVVAAGGKEQNLAQLRYHQ----GFLSCYDPINIQFTSGT 266

  Fly   255 TGLPKGVMLSHNNITSNCEQVQASLPLDLMGPQNT-------LPGVLPFFHIYG-LTVVMLSKLG 311
            ||.|||..|||:||.:|...:...|.:    |..|       ||  .|.:|..| :...|:|.:.
  Rat   267 TGNPKGATLSHHNIVNNSNLIGQRLKM----PAKTAEELRMVLP--CPLYHCLGSVGGTMVSVVH 325

  Fly   312 QGCRLATMPCFKPDDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLK--VVMSGAAPIG 374
            ....|.:.|.|.....:.::.:.:|::|...|.:.:.::|.|..:......::  |:....||
  Rat   326 GATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTTIRGGVIAGSLAP-- 388

  Fly   375 QHDVERFLNKFPNTVFKQGYGMTEASPVVLLT-PEG--NKVYASTGVLPASTEAKIVPLDGSDAK 436
            ...:...::|.........||.||.|||..:. ||.  .:...|.|.:...|||:||.::..:..
  Rat   389 PELIRAIISKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNMETGELT 453

  Fly   437 GVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVK 501
            .:  ...||||:||..||.||....:....|.....|.|:||:|..||.|...|..|.|::|...
  Rat   454 KL--NMPGELCIRGYCVMQGYWGEPQKTFETVGQDRWYRTGDIASMDEQGFCRIVGRSKDMIIRG 516

  Fly   502 GFQVPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYK 566
            |..:.|||||.....||::.||.|.|:..:..||...|.:.|:.||..:.|||.|:...:::|:
  Rat   517 GENIYPAELEDFFHKHPQVQEAQVVGVKDDRMGEEICACIRLKSGETTTEEEIKAFCKGKISHF- 580

  Fly   567 KLEGGVIFVDEVPKNPTGKILRRELKEK 594
            |:...::||:..|...:|||.:.:|:|:
  Rat   581 KIPRYIVFVEGYPLTVSGKIQKFKLREQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	150/548 (27%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	144/526 (27%)
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	150/548 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710