DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and DIP2B

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	632	Identity:	138/632 - (21%)
Similarity:	229/632 - (36%)	Gaps:	171/632 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 HEYV-----WRD--------FKKWERRTAAVCVITDRQYTFAQMRDASAAFAVRLQTKFNLQKPD 129
            |:::     ||.        |.....:...||..     :..|:...:...|..|..|.:|...|
Human   988 HQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTA-----SCLQLHKRAERIASVLGDKGHLNAGD 1047

  Fly   130 VLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQASK 194
            .:.:..|...|...|..|.:.||....||.|.:     |:.||.:     :.||.....:|:|:.
Human  1048 NVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPH-----AQNLTAT-----LPTVRMIVDVSKAAC 1102

  Fly   195 LVGRQIPIAVVRTSAEEALPEGAIDFSELTSTQNVRYEDL---KAP---KEASADDMVFLPFSSG 253
            ::..|..:.::| |.|.|   .|:|..  |....:..:||   :.|   |..:.:.:.:|.||..
Human  1103 ILTSQTLMRLLR-SREAA---AAVDVK--TWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVS 1161

  Fly   254 TTGLPKGVMLSHNNITSNCEQV----------QASLPLD---------------LMGPQNTLPGV 293
            |||:..||.:||:.:.:.|..:          |.::.||               ..|.|:.|
Human  1162 TTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSVL--- 1223

  Fly   294 LPFFHIYGLTVVMLSKLGQ------GCRLATMP-CFKPDDFMRSLDKYQGSILNLV--------- 342
            :|...:.....:.||.:.|      .|..:.|. |.|.......:.|.:|..|:.|
Human  1224 IPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCVRTCVVVAEE 1288

  Fly   343 -PPIALFMINHPKLTQETAPHLKVV----------------MSGAAPIG--------QHDVERFL 382
             |.:|| ..:..||.::.....:.|                .||..|..        :||..|.:
Human  1289 RPRVAL-QQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLV 1352

  Fly   383 NKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVPLDGSDAKGVGPRTTGELC 447
            .:              .:|..||..|..|      :||.   .|:|.::......||....||:.
Human  1353 ER--------------GAPQSLLLSESGK------ILPG---VKVVIVNPETKGPVGDSHLGEIW 1394

  Fly   448 VRGPQVMAGY--------LNNDEAN-QVTFYPGN-----WLRSGDVAFY----------DEDGLF 488
            |..|...:||        |..|..| :::|  |:     |.|:|.:.|.          :.....
Human  1395 VNSPHTASGYYTIYDSETLQADHFNTRLSF--GDAAQTLWARTGYLGFVRRTELTAATGERHDAL 1457

  Fly   489 YITDRMKELIKVKGFQVPPAELE-AVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAE 552
            |:...:.|.::::|.:..|.::| :|.|.|..|.|.|||...:..      .:||...|.:..|.
Human  1458 YVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTNLL------VVVVELCGSEQEAL 1516

  Fly   553 EISAYVAERV--AHYKKLEGGVIFVDE--VPKNPTGKILRRELKEKF 595
            ::...|...|  .|| .:.|.|:.||.  :|.|..|:..|..|::.|
Human  1517 DLVPLVTNVVLEEHY-LIVGVVVVVDPGVIPINSRGEKQRMHLRDSF 1562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	137/630 (22%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	129/588 (22%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395
		AFD_class_I	360..924	CDD:302604
		AMP-binding	995..1470	CDD:278902	108/524 (21%)
		AFD_class_I	1012..1565	CDD:302604	134/608 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900