DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and acsl3a

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001038593.1	Gene:	acsl3a / 567157	ZFINID:	ZDB-GENE-050420-181	Length:	713	Species:	Danio rerio

Alignment Length:	686	Identity:	148/686 - (21%)
Similarity:	245/686 - (35%)	Gaps:	219/686 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VSETDKFLHYSPEDGYYKTSPFDPVTIPNVPLHEYVWRD----FKKWERRTAAVCVITDR-QYTF 105
            :||.|:    :.|||         .....|.|.||.|..    ||:.....:.:..:..: ....
Zfish   104 LSEEDE----TQEDG---------KVFKKVILGEYRWMSYEQVFKEVNAFGSGLAALGQKPMKNI 155

  Fly   106 AQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPI-ATLG--AIEAGLTVTTVNPVYTPDEI 167
            |...:..|.:.:..|..|           :.|.|...: :|||  ||..||....|:.:.|..::
Zfish   156 AIFCETRAEWIIAAQACF-----------MYNFPLVTLYSTLGGPAIAHGLNEAEVSHIITSKDL 209

  Fly   168 ARQLTFSGAKFLVGTVSGFATLSQASKLVGRQIP----IAVV--RTSAEEALPEGAIDFSELTST 226
                                 |....|.:..::|    :.||  :.|.....|.| |....:.|.
Zfish   210 ---------------------LETKLKSIFIEVPRLCHVIVVDDKLSTSSEYPRG-ISIHSMASV 252

  Fly   227 QNV--RYEDLKAPKE-ASADDMVFLPFSSGTTGLPKGVMLSHNNITSNCEQVQASLPLDLMGPQN 288
            :.:  |.|:...||. ..:.|:..:.::||:||:|||||:||:||.|....:...:|  .:...:
Zfish   253 KELGARPENASKPKNPPCSSDVAVIMYTSGSTGVPKGVMISHSNIISGITGMTHRIP--KLVEDD 315

  Fly   289 TLPGVLPFFHIYGLTVVMLSKLGQGCRLA-TMPCFKPDDFMRSLDKYQGSILNLVPPI------- 345
            |..|.||..|:..|:..|:. |..|||:. :.|....|...:.....:|.|..|.|.:
Zfish   316 TYIGYLPLAHVLELSAEMVC-LAHGCRIGYSSPQTLSDQSTKIKKGSRGDISVLRPTLMAAVPEI 379

  Fly   346 --------------------ALFMINHPKLTQETA---------------------PHLKVVMSG 369
                                .||::.:....::.|                     ..|:|::||
Zfish   380 MDRIYKNVMLRVEQMSGFQRTLFLLAYNYKMEQLAMGYSTPLCDKLVFRKVRALLGGRLRVLLSG 444

  Fly   370 AAPIGQHDVERFLNKFPNTVFKQGYGMTE------------------ASPVVLLT------PEGN 410
            .||:.. ..:||:|........||||:||                  .:|:|...      .||.
Zfish   445 GAPLSA-ATQRFMNICFCCPVGQGYGLTETCGAGTISHLWDYSTGRVGAPLVCCELQLKDWIEGG 508

  Fly   411 KVYASTGVLPASTEAKIVPLDGSDAKGVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPG---- 471
              |.||. ||.                  ||  ||:.|.||.:..||..|.......|:..
Zfish   509 --YHSTD-LPC------------------PR--GEILVGGPSITMGYYKNTHKTSEDFFVDKKGQ 550

  Fly   472 NWLRSGDVAFYDEDGLFYITDRMKELIKVK-GFQVPPAELEAVLRDHPKI---------LEAAVF 526
            .|..:||:.....||...|.||.|:|:|:: |..|...::||.|::.|.:         .|:.|.
Zfish   551 RWFCTGDIGEIHGDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLVDNICAYANSDESYVI 615

  Fly   527 G--IPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLEGGVIFV------------DE 577
            |  :|::      :.::.|.:.::...      :.|.:.:...:|..|:.|            .|
Zfish   616 GFVVPNQ------KQLLALAERKRVRG------LWEELCNNPVIEEAVLTVLTEAALTAQLERFE 668

  Fly   578 VPKN----------PTG------KILRRELKEKFSD 597
            :|:.          .||      |:.|:|||..:.:
Zfish   669 IPRKIRLSVEPWTPDTGLVTDSFKLKRKELKTHYQN 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	141/651 (22%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	131/617 (21%)
acsl3a	NP_001038593.1	PLN02387	77..710	CDD:215217	148/686 (22%)
acsl3a	NP_001038593.1	LC-FACS_euk	123..710	CDD:213293	140/654 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930