DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and acsl3b

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001139404.1	Gene:	acsl3b / 559656	ZFINID:	ZDB-GENE-030131-492	Length:	711	Species:	Danio rerio

Alignment Length:	731	Identity:	167/731 - (22%)
Similarity:	282/731 - (38%)	Gaps:	207/731 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AQLLRMRSATAFGSAATRSITTNRRQRTTSTASAQRERTQSVSETDKFLHYS----PEDGYYKT- 64
            |:..|:::....|:.|......|.:.:..|...      :.|...||...|:    ||.....|
Zfish    41 ARAKRVKARAINGNPAGPYRAVNSQLKLASLLH------EGVDTLDKVFEYAVVHFPERDCLGTR 99

  Fly    65 ---SPFDPVTIPN------VPLHEYVWRDF-------KKWERRTAA-----VCVITDRQYTFAQM 108
               |..|.:. ||      |.|.:|.|..:       :::....||     :|.|.    .|.:.
Zfish   100 ELLSEEDEIQ-PNGKVFKKVILGDYNWLSYQDTFHLAQRFGSGLAALGQKPLCNIA----IFCET 159

  Fly   109 RDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATL------GAIEAGLTVTTVNPVYTPDEI 167
            |   |.:.:..|..|              :..:|:.||      .||..||..|.|..:.|
Zfish   160 R---AEWVIAAQACF--------------MYNFPLVTLYSTLGGSAIAHGLNETEVTHIVT---- 203

  Fly   168 ARQLTFSGAKFLVGTVSGFATLSQASKLVGRQIPIAVVRTSAEEALPEGAI-----DFSELTS-T 226
            ::.|..|..|         |.|.:..:|  :.|.:...:.::...||.|.:     ...||.| .
Zfish   204 SKDLLQSRLK---------AILLEVPRL--KHIIVVDTKPTSWPDLPRGIMVHNMAAVQELGSKP 257

  Fly   227 QNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNITSNCEQVQASLP-LDLMGPQNTL 290
            :|:    :.:.::....|:..:.::||:||:|||||:||:||.:....:...:| ||   ..:|.
Zfish   258 ENI----MVSRRQPVPSDIAVIMYTSGSTGIPKGVMISHSNIIAGITGMAERIPNLD---ENDTY 315

  Fly   291 PGVLPFFHIYGLTVVMLSKLGQGCRLA-TMPCFKPDDFMRSLDKYQG-------SILNLVPPI-- 345
            .|.||..|:..|:..::. :..|||:. :.|....|...:.....:|       :::..||.|
Zfish   316 IGYLPLAHVLELSAELVC-VSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEIMD 379

  Fly   346 ------------------ALFMINHP-KLTQ----ETAP----------------HLKVVMSGAA 371
                              .||::.:. |:.|    .|.|                :.:|::||.|
Zfish   380 RIYKNVMTKVEEMSSVQKTLFVLAYNYKMEQISKGYTTPLCDRLVFRKVRSLLGGNTRVLLSGGA 444

  Fly   372 PIGQHDVERFLNKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVPLDGSDAK 436
            |:.. ..:||:|........||||:||......::...:   .|||.:.|......:.|...:..
Zfish   445 PLSA-ATQRFMNICFCCPVGQGYGLTETCGAGTISEMSD---YSTGRVGAPLVCSEIMLKDWEEG 505

  Fly   437 GV----GPRTTGELCVRGPQVMAGYLNNDEANQVTFYPG----NWLRSGDVAFYDEDGLFYITDR 493
            |.    .|...||:.:.||.|..||..|::.|:..|:..    .|..:||:..:..||...|.||
Zfish   506 GYFSTDKPNPRGEILIGGPNVTMGYYKNEQKNREDFFEDKNGQRWFCTGDIGEFHPDGCLKIIDR 570

  Fly   494 MKELIKVK-GFQVPPAELEAVLRDHPKI---------LEAAVFG--IPHEFNGEAPRAIVVL--R 544
            .|:|:|:: |..|...::||||::.|.|         .|:.|.|  :|::      :.:..|  :
Zfish   571 KKDLVKLQAGEYVSLGKVEAVLKNCPLIDNICAYANSDESYVIGFVVPNQ------KQLTALAGQ 629

  Fly   545 QGEKASAEEISAYVAERVAHYKKLEGGV--IFVD----------EVPKN----------PTG--- 584
            :|.:.|.|||        .::.::|..|  |..|          |:||.          .||
Zfish   630 KGIRGSWEEI--------CNHAEMEKEVLRIITDAAISGKLERFEIPKKICLSAEPWTPETGLVT 686

  Fly   585 ---KILRRELKEKFSD 597
               |:.|:|||..:.|
Zfish   687 DAFKLKRKELKTHYQD 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	148/641 (23%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	137/599 (23%)
acsl3b	NP_001139404.1	PLN02387	43..708	CDD:215217	166/729 (23%)
acsl3b	NP_001139404.1	LC-FACS_euk	121..708	CDD:213293	148/644 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582958
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930