DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and acsl1a

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001027007.1	Gene:	acsl1a / 555308	ZFINID:	ZDB-GENE-050809-115	Length:	697	Species:	Danio rerio

Alignment Length:	714	Identity:	154/714 - (21%)
Similarity:	260/714 - (36%)	Gaps:	186/714 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TAFGSAATRSITT--------------NRRQRTTSTASAQRERTQSVSETDKFLHYSPEDGYYKT 64
            |..|..|..:|||              :...::......:..|...:.:.|..:.|     |||
Zfish    29 TLMGMGAFAAITTYWLATRPKALKPPCDLTMQSVEVPGKEYARRSILMDNDTHMTY-----YYK- 87

  Fly    65 SPFDPVT----------IP-NVPL-------HEYVWRDFKKWERRTAAVCVITDRQYTFAQMRDA 111
               |.:|          :| |.|.       ..|.|..:|:          :.||         |
Zfish    88 ---DALTLYEFFLRGLRVPNNGPCLGSRKAGQPYKWLSYKE----------VADR---------A 130

  Fly   112 SAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQ-LTFSG 175
            ..|.:..|....:......:.|...|.||:.|:.|......|...   |:|  |.:..: :::..
Zfish   131 EFAGSALLHRGHSQSGDKYIGIFAQNRPEWTISELACYTYSLVAV---PLY--DTLGTEAISYVI 190

  Fly   176 AKFLVGTVSGFATLSQASKLV-----GRQ--IPIAVVRTSAEEALPEGA----IDFSELTSTQNV 229
            .|..:.|:  ...::..::|:     ||:  :...|:..|.:..|...|    ||...|...:.:
Zfish   191 DKASITTI--ICDIADKARLILDCVSGRKHSVTTIVIMESFDSELTAQAQNCGIDIISLKELEAI 253

  Fly   230 RYEDLKAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNITSNCEQVQASLPLDLMGPQNTLP-GV 293
            ...:.|.|.....:|:..:.|:|||||.|||.||:|.|:.|||........:..|..|..:. ..
Zfish   254 GKANHKTPIPPKPEDLALICFTSGTTGNPKGAMLTHGNVVSNCSAFIKITEVHCMLNQTDIHISY 318

  Fly   294 LPFFHIYGLTV--VMLSKLGQGCRLATMPCFKPDD--FMRSLDKYQGSILNLVP----------- 343
            ||..|::...|  |:|      |..|.:..|:.|.  .|..|...:.:|..:||
Zfish   319 LPLAHMFERVVEGVLL------CHGAKIGYFQGDIRLLMDDLKNLKPTIFPVVPRLLNRMFDKIF 377

  Fly   344 -----PIALFMIN-------------------------HPKLTQETAPHLKVVMSGAAPIGQHDV 378
                 |:..::::                         ..|:.......::::::||||:.. .|
Zfish   378 GQANTPLKRWLLDFATSRKEAELKSGVVRKDSMWDKLIFSKVQASLGGRVRLMITGAAPVSP-TV 441

  Fly   379 ERFLNKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGV-LPASTEAKIVPLDGSDAKGVGPRT 442
            ..||.......|.:|||.||.:....::..|:......|. ||.:. .|:|  |.::........
Zfish   442 LTFLRAALGCQFYEGYGQTECTAGCTMSLPGDWTAGHVGAPLPCNF-VKLV--DVAEMNYFAANG 503

  Fly   443 TGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKV-KGFQVP 506
            .||:||:||.|..|||.:.|..........||.:||:..:..:|...|.||.|.:.|: :|..:.
Zfish   504 EGEVCVKGPNVFQGYLKDPEQTSGAVDKAGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIA 568

  Fly   507 PAELEAV-LRDHPKILEAAVF----------------------------GIPHEFNG-----EAP 537
            |.::|.: :|..|   .|.||                            ||...||.     |..
Zfish   569 PEKIENIYIRSDP---VAQVFVHGDSLQACLVGVVVPDPDFLPGWAKNRGIEGSFNDLCKSKEVK 630

  Fly   538 RAIV--VLRQGEKASAEEISAYVAERVAHYK--KLEGGVIFVDEVPKNPTGKILRRELKEKFSD 597
            .||:  :::.|::|..:... .|.:...|.:  .::.|::       .||.|..|.|||.:|.:
Zfish   631 NAILEDMIQLGKEAGLKSFE-QVRDIALHLEMFSVQNGLL-------TPTLKAKRTELKSRFRE 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	136/622 (22%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	129/585 (22%)
acsl1a	NP_001027007.1	PLN02736	88..695	CDD:178337	142/646 (22%)
acsl1a	NP_001027007.1	LC-FACS_euk	116..692	CDD:213293	137/618 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930