DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and Acsl4

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_997508.1	Gene:	Acsl4 / 50790	MGIID:	1354713	Length:	711	Species:	Mus musculus

Alignment Length:	718	Identity:	158/718 - (22%)
Similarity:	259/718 - (36%)	Gaps:	199/718 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TNRRQRTTSTASAQRERTQSVSETDKFLHYSPEDGYYKTSPFDPVTIPNVP------------LH 78
            ||.:::     :|..:|.::...:||     |...|...:.||.:.:.::|            :.
Mouse    34 TNAKKK-----NAMAKRIKAKPTSDK-----PGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVA 88

  Fly    79 EYVWRD--------------------FK-------KWERRTAAVCVITDRQYTFAQMRDASAAFA 116
            ::..:|                    ||       ||.......|.:.:              |.
Mouse    89 KFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWINYLEVNCRVNN--------------FG 139

  Fly   117 VRLQTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVG 181
            ..| |...|:..:.:||......|:.||.....:....:.|:......:.:...|..|.|.:|:.
Mouse   140 SGL-TALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEASYLIT 203

  Fly   182 TVSGFATLSQASKLVGRQIPIAVV--------RTSAEEALPEGAIDFSELTSTQNVRYEDLKA-- 236
            :|.     ...|||....:.|..|        :|......|||.    |:.|.|:|  |:|.|
Mouse   204 SVE-----LLESKLKAALVDINCVKHIIYVDNKTINRAEYPEGL----EIHSMQSV--EELGAKP 257

  Fly   237 ------PKEASADDMVFLPFSSGTTGLPKGVMLSHNNI----TSNCEQVQASLPLDLMGPQNTLP 291
                  |...:..||..:.::||:||.|||||:.|:|:    |..||::..      :||::|..
Mouse   258 ENLSVPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPG------LGPKDTYI 316

  Fly   292 GVLPFFHIYGLTVVMLSKLGQGCRLA-TMPCFKPDDFMRSLDKYQG-------SILNLVPPI--- 345
            |.||..|:..|| ..:|....|||:. :.|....|...:.....:|       :::..||.|
Mouse   317 GYLPLAHVLELT-AEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDR 380

  Fly   346 -----------------ALFMINHP-KLTQ----ETAP----------------HLKVVMSGAAP 372
                             .||.|.:. ||.|    ..||                ::::::||.||
Mouse   381 IYKNVMSKVQEMNYVQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAP 445

  Fly   373 IGQHDVERFLNKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVP-LDGSDAK 436
            :.. ...||:|........||||:||:.....:|...:......|......|.|:.. .:|....
Mouse   446 LSP-QTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTV 509

  Fly   437 GVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPG----NWLRSGDVAFYDEDGLFYITDRMKEL 497
            ...|...||:.:.|..:..||..|:|.....:...    .|..:||:..:..||...|.||.|:|
Mouse   510 HDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYCVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDL 574

  Fly   498 IKVK-GFQVPPAELEAVLRDHPKILEAAVFG-----------IPHEFNGEAPRAIVVLRQ----- 545
            :|:: |..|...::||.|::.|.|.....|.           :|::      :.:.:|.|
Mouse   575 VKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQ------KKLTLLAQQKGVE 633

  Fly   546 -------GEKASAEEISAYVAERVAHYKKLEGGVIFV----DEVPKNP-TG------KILRRELK 592
                   ...|...||...:.| .|:..|||...|.:    ...|..| ||      |:.|:|||
Mouse   634 GSWVDICNNPAMEAEILKEIRE-AANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELK 697

  Fly   593 EKF 595
            ..:
Mouse   698 NHY 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	147/653 (23%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	137/596 (23%)
Acsl4	NP_997508.1	LC_FACS_euk1	121..696	CDD:341294	141/615 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839022
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930