DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and CG11659

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	133/557 - (23%)
Similarity:	232/557 - (41%)	Gaps:	45/557 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 YSPEDGY---YKTSPFDPVT---IPNVPLHEYVWRDFKKWERRTAAVCVITDRQYTFAQMRDASA 113
            |:||:.|   .|....:||.   .|::.:.|.::.:.::..:.||.:........|    |....
  Fly     3 YTPENSYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLT----RGELL 63

  Fly   114 AFAVRLQT---KFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSG 175
            |.|:||.:   ...|.:.|::.:...|..............|:...::|..|..|.|.:....:.
  Fly    64 ANAMRLASYMRSLGLLQSDIVGLIGRNTTHMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTR 128

  Fly   176 AKFLVGTVSGFATLSQASKLVGRQIPIAVVRTSAEEALPEGAIDFSELTST---QNVRYEDLKAP 237
            ...:......|..:..|:..:  .:.|..:|..     |..:|...|:.:|   :|.:    .|.
  Fly   129 PSIIFCDGDEFEKVRSATAEL--DVKIVTMRNH-----PLDSIKIDEVVATPIEENFQ----PAK 182

  Fly   238 KEASADDMVFLPFSSGTTGLPKGVMLSHNN--ITSNCEQVQASLPLDLMGPQNTLPGVLPFFHIY 300
            .|...|..:.:..||||||.||.|.::::.  :..|.....|    |:....|||.      .|.
  Fly   183 LEKGNDQTLAILCSSGTTGTPKAVTITNSRHILAGNYHLTTA----DVQYSHNTLD------WIT 237

  Fly   301 GLTVVMLSKLGQGCRLATMPCFKPDDFMRSLDKYQGSILNLVPPIAL-FMINHPKLTQETAPHLK 364
            ||...:.|.:....|:.....|.|...:|.:::|:.: ..:.||.:: .|||.|.........|:
  Fly   238 GLLTTITSGVFSTTRIIADNAFDPAFALRIIEEYKVT-WTIQPPSSMALMINCPDFETCDLSSLR 301

  Fly   365 VVMSGAAPIGQHDVERFLNKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVP 429
            ..|.|.:.......:...::..:...:..||.||...:..:....::...|.|.|....:.||
  Fly   302 CYMFGGSRAALEVQKGIRSRLSHNCLQFVYGFTELGAMATINCHFDEKTGSVGQLVNGLKMKI-- 364

  Fly   430 LDGSDAKGVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRM 494
             ...|.:.:||...||:|:...|..:||..|:...:.......|..|||:.:.|.||..||.||.
  Fly   365 -KNDDGESLGPDEIGEVCIMNNQHWSGYYGNEVETRNMRDSLGWYHSGDLGYMDRDGFLYIMDRK 428

  Fly   495 KELIKVKGFQVPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVA 559
            ||::|.:.....|.::|:|:.:.|::.|..||||.....|:...|.||.:.|.:..|:::..||.
  Fly   429 KEMLKYQNIMYYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVR 493

  Fly   560 ERV-AHYKKLEGGVIFVDEVPKNPTGKILRRELKEKF 595
            .|. :.||:|.||.:.||::.::..||..|...|..|
  Fly   494 SRTDSKYKQLNGGAVIVDDLQRSANGKTNRMANKAHF 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	124/527 (24%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	119/497 (24%)
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	123/525 (23%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	120/503 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800