DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and CG17999

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	133/541 - (24%)
Similarity:	228/541 - (42%)	Gaps:	54/541 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PNVPLHEYVWRDFKKWERRTAAVCVITDRQYTFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPN 137
            |.:.|.|.:.|..:....:...:|..|.::.|.||:...||..|...: :..|::.||:.|...|
  Fly    25 PEMTLGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIAQAFK-RLGLRRGDVVGISANN 88

  Fly   138 LPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQASKLVGRQIPI 202
            ........:.|:..|:.:..::|.:|.:.:......:..|.:...|..:..:...:..:.....|
  Fly    89 STYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVENYHIIKTVNGKLQNPAKI 153

  Fly   203 AVVRTSAEEALPEGAIDFSELTSTQN----VRYEDLKAPKEASADDMVFLPFSSGTTGLPKGVML 263
            .:|....     ||.:|.||:.:.::    ..|  :..|| ...|...|:..||||||:||||..
  Fly   154 YLVNGKL-----EGVLDISEMLNDEDSITAAAY--VPCPK-LHGDHTAFIVCSSGTTGMPKGVTR 210

  Fly   264 SHNNITSNCEQVQASLPLDLMGPQN-TLPGVL----PFFHIYGLTVVMLSKLGQGC-RLATMPCF 322
            ||.::..||:           .|.. |...||    |.:.|.| |:::|:.|..|| |:.|...:
  Fly   211 SHRSLLCNCK-----------NPNTYTRDSVLLSFSPLYWISG-TIILLASLLNGCRRIITNRPY 263

  Fly   323 KPDDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHL---KVVMSGAAPIGQHDVERFLNK 384
            ..:..::.:.:::.:.|.|.......:..|.....|....|   :|::...:.:.:....|....
  Fly   264 SVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELKAQLQSIRVLIGAGSKVCKAVCRRMYEL 328

  Fly   385 FPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKI-----VPLDGSDAKGVGPRTTG 444
            ..|..|..|||::|...  |....|..| ...|.:..:.|.::     :||        |....|
  Fly   329 IGNQRFVVGYGLSEMGG--LSKNVGGPV-GCEGKVMRNVELRVLDKLKMPL--------GINEVG 382

  Fly   445 ELCVRGPQVMAGYLNNDEA-NQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPA 508
            .:..|.....|||..|.|| .:.....|.|.|:||:.:.|.:|..||..|..::.|...||:.|.
  Fly   383 IIYARLRFKWAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIYPE 447

  Fly   509 ELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLR---QGEKASAEEISAYVAERVAHYKKLEG 570
            ::|..:...|.:.||.|||||...:.......||..   :||:.:|:.|...|...::....:.|
  Fly   448 QIEEFILRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTADHIRNIVEHHLSGAYHIRG 512

  Fly   571 GVIFVDEVPKNPTGKILRREL 591
            ||.|:|.:||.|..|:.||::
  Fly   513 GVYFIDSLPKTPNDKLQRRKV 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	132/537 (25%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	126/509 (25%)
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	133/541 (25%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	127/522 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850