DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and Acsm1

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001101972.2	Gene:	Acsm1 / 361638	RGDID:	1306813	Length:	577	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	157/600 - (26%)
Similarity:	253/600 - (42%)	Gaps:	98/600 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KFLH----YSPE--------DGYYKTSPFDPVTIPNVPLH--EYVWRDFKKWERR--TAAVCVIT 99
            ||||    :.|:        ||..:.:.:|.....|...|  :| |...:...:|  ..|:..:.
  Rat    15 KFLHRFSLHRPQLHRWLISGDGAQRWNDYDSPEEFNFASHVLDY-WAQMEGEGKRGPGPALWWVN 78

  Fly   100 DR----QYTFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNP 160
            |:    :::|.::||.|...|...:....||..|.||:.||.:||:.:.|:|.|..|:.......
  Rat    79 DQGDEIKWSFRELRDLSRRAANVFEQTCGLQHGDRLALILPRVPEWWLVTVGCIRTGVIFIPGTA 143

  Fly   161 VYTPDEIARQLTFSGAKFLVGTVSGFATL-SQASKLVGRQIPIAVVRTSAEEALPEGAIDFSELT 224
            .....:|..::..|.||.:|.|.|....: |.||:..|.:..|.|     .:...||.::|..|.
  Rat   144 QMKAKDILYRIQMSQAKAIVTTDSLVPEVESVASECPGLKTKIVV-----SDHNHEGWLNFRTLL 203

  Fly   225 STQNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNITSNCEQVQASLPLDLMGPQNT 289
            .:.:   .|....|....|.||.. |:|||||.||  |..||               ..:..:::
  Rat   204 RSAS---PDHTCVKSKMKDPMVIF-FTSGTTGYPK--MAKHN---------------QGLAFRSS 247

  Fly   290 LPGVLPFFHIYGLTVV-MLSKLG-----QGCRL------AT-----MPCFKPDDFMRSLDKYQGS 337
            :|....|..:....|: .:|..|     .||.|      ||     :|.|.|...:.:|.||..:
  Rat   248 VPSCRKFLKLKTSDVIWCMSDPGWILATVGCLLEPWTAGATVFVHNLPQFDPKVIVETLFKYPIT 312

  Fly   338 ILNLVPPIALFMINHPKLTQETAPHLKVVMSGAAPIGQHDVERFLNKFPNTVFKQGYGMTEASPV 402
            .. |..|....|:....::....|.|:...:|...:...:.|::..:...:: .:.||.:|....
  Rat   313 QC-LAAPAVYRMVLQKNISNLRFPTLEHCATGGESLLPEEYEQWKQRTGLSI-HEVYGQSETGIT 375

  Fly   403 VLLTPEGNKVYASTGVLPASTEAKIVPLDGS--DAKG--VGPRTTGELCVR-GPQ----VMAGYL 458
            .       .::....|...|....|:|.|..  |.||  :.|.|.|.:.:| .|.    :..||.
  Rat   376 C-------AIFREMKVKRGSIGKAILPFDIQIIDEKGNILPPNTEGYIGIRIKPTRPLGLFVGYE 433

  Fly   459 NNDE-ANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPAELEAVLRDHPKILE 522
            |:.| .::|..  |::..|||.|..||||..:...|..::|...|:::.|.|:|..|.:||.:.|
  Rat   434 NSPEKTSEVEC--GDFYNSGDRATIDEDGYIWFLGRSDDVINASGYRIGPTEVENALVEHPAVSE 496

  Fly   523 AAVFGIPHEFNGEAPRAIVVLR-----QGEKASAEEISAYVAERVAHYK---KLEGGVIFVDEVP 579
            :||...|.:..||..:|.:||.     ..::...:|:..:|....|.||   |:|    ||.|:|
  Rat   497 SAVVSSPDKDRGEVVKAFIVLNPEFLSHDQEQLIKELQEHVKSVTAPYKYPRKVE----FVSELP 557

  Fly   580 KNPTGKILRRELKEK 594
            |..||||.|:||:.|
  Rat   558 KTITGKIKRKELRNK 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	147/561 (26%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	138/527 (26%)
Acsm1	NP_001101972.2	AFD_class_I	46..573	CDD:302604	148/568 (26%)
Acsm1	NP_001101972.2	Acs	46..570	CDD:223442	147/565 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010