DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and AgaP_AGAP003482

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_560023.4	Gene:	AgaP_AGAP003482 / 3290850	VectorBaseID:	AGAP003482	Length:	545	Species:	Anopheles gambiae

Alignment Length:	507	Identity:	180/507 - (35%)
Similarity:	273/507 - (53%)	Gaps:	41/507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 TFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIA 168
            |:.|:...|...|.|.. :..:::..|:.||..|..::||.|...:..|.||..:|..|:..|:.
Mosquito    54 TYHQILARSLKLANRFH-RLGIKRNSVVGICSENSVQFPIITFATLMLGGTVLPINYGYSEVELQ 117

  Fly   169 RQLTFSGAKFLVGTVSGFATLSQASKLV---------------GRQIPIAVVRTSAEEALPEGAI 218
            ..|.      |...::.||:.....|:|               |:|      |.|...||.|...
Mosquito   118 HVLQ------LTKPIALFASEQPLQKIVTIRNVLPSVKLLVSLGKQ------RPSRGIALLEDFF 170

  Fly   219 DFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNI-TSNCEQVQASLPLD 282
            |.|...|..:...:.:...::.:.     :..|||||||||.|.|:|:|: |....|.:.....:
Mosquito   171 DNSPPGSLHSFTPQPVPLRQQVAV-----MVMSSGTTGLPKAVQLTHHNVMTVMAYQAEDPRYTE 230

  Fly   283 LMGPQNTLPGVLPFFHIYGLTVVMLSKLGQGCRLATMPCFKPDDFMRSLDKYQGSILNLVPPIAL 347
            |..|...| |:|||:|::|..:.:.|.|.: ..:..:|.|:||.|:|::..::.::.:||||:.:
Mosquito   231 LPVPVRVL-GLLPFYHVFGFMLSLNSCLNK-VPMVVLPRFEPDLFLRTIQNHRITMASLVPPLVV 293

  Fly   348 FMINHPKLTQETAPHLKVVMSGAAPIGQHDVERFLNKFPNT-VFKQGYGMTEASPVVLLTPEGNK 411
            |:...|.........|..::.||||:.:...|...::.||. ..:.||||:|.| :.:::...:|
Mosquito   294 FLAKSPLTQGYDLSSLHALLCGAAPLSREIEELVQSRLPNVQTVRTGYGMSETS-LGVISRMNDK 357

  Fly   412 VYASTGVLPASTEAKIVPLDGSDAKGVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRS 476
            | .|.|.:..:|..|:|.|:...|  :||..|||:||:||.||.|||:||.|.........||.:
Mosquito   358 V-GSVGKVHKTTYVKVVDLETGCA--LGPNQTGEICVKGPLVMKGYLHNDRATGEIIDADGWLHT 419

  Fly   477 GDVAFYDEDGLFYITDRMKELIKVKGFQVPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIV 541
            |||.:|||:..|:|.||:|:|||.|||||||||||.||..|.::.:.||.|:|.|..||.|.|.|
Mosquito   420 GDVGYYDEEQDFFIVDRIKDLIKYKGFQVPPAELEDVLLSHRQVRDCAVVGVPDEMAGELPAAFV 484

  Fly   542 VLRQGEKASAEEISAYVAERVAHYKKLEGGVIFVDEVPKNPTGKILRRELKE 593
            ||:.||..:|.||..|||.:::..|:|.|||.||||:||..:||||||:|::
Mosquito   485 VLQAGESVTANEIERYVASKLSPQKQLRGGVFFVDEIPKTGSGKILRRQLRD 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	180/507 (36%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	175/499 (35%)
AgaP_AGAP003482	XP_560023.4	Firefly_Luc_like	43..530	CDD:213279	175/499 (35%)
AgaP_AGAP003482	XP_560023.4	CaiC	26..544	CDD:223395	180/507 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54045
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
TreeFam	0	0.000	Not matched by this tool.
	6	5.830