DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and Acsf2

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_722502.1	Gene:	Acsf2 / 264895	MGIID:	2388287	Length:	615	Species:	Mus musculus

Alignment Length:	546	Identity:	149/546 - (27%)
Similarity:	246/546 - (45%)	Gaps:	57/546 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 KKWERRTAAVCVITDRQYTFAQMRD-----ASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIAT 145
            :::..|.|.|.:..:.:..|||:::     ||...::      .|:|.|.|.:..||...:.:..
Mouse    83 QRFPDREALVILHENIRLNFAQLKEEVDKAASGLLSI------GLRKGDRLGMWGPNSYAWVLIQ 141

  Fly   146 LGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLV-----GTVSGFATL---------SQASKLV 196
            |...:||:.:.:|||.|...|:...|...|.|.:|     .|...:..|         :|...|.
Mouse   142 LATAQAGIILVSVNPAYQSSELEYVLRKVGCKGIVFPKQFKTQQYYDILKQVCPELEKAQPGALK 206

  Fly   197 GRQIPIAVVRTSAEEALPEGAIDFSELTST----QN---VRYEDLKAPKEASADDMVFLPFSSGT 254
            ..::|......|.:..|| |.:...::.:.    ||   :||..    :..|..|.:.:.|:|||
Mouse   207 SERLPDLTTVISVDAPLP-GTLLLDDIVAAGGKEQNLAQLRYNQ----RFLSCYDPINIQFTSGT 266

  Fly   255 TGLPKGVMLSHNNITSNCEQVQASLPLDLMGPQNT-------LPGVLPFFHIYG-LTVVMLSKLG 311
            ||.|||..|||:||.:|...:...|.:    |..|       ||.  |.:|..| :...|:|.:.
Mouse   267 TGNPKGATLSHHNIVNNSMLIGQRLKM----PTKTAEELRLVLPS--PLYHCLGSVGGTMVSMMH 325

  Fly   312 QGCRLATMPCFKPDDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLKVVMSGAAPIGQH 376
            ....|.:.|.|.....:.::.:.:|::|...|.:.:.::|.|..:......::..:...:|....
Mouse   326 GATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTSIRGGVIAGSPAPPE 390

  Fly   377 DVERFLNKFPNTVFKQGYGMTEASPVVLLT-PEG--NKVYASTGVLPASTEAKIVPLDGSDAKGV 438
            .:...:||.........||.||.|||..:. ||.  .:...|.|.:...|||:||.::..:...:
Mouse   391 LIRAIINKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNVETGELTNL 455

  Fly   439 GPRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGF 503
              ...|||.:||..||.||....:....|.....|.|:||:|..||.|...|..|.|::|...|.
Mouse   456 --NVPGELYIRGYCVMQGYWGEPQKTFETVGQDKWYRTGDIALMDEQGFCKIVGRSKDMIIRGGE 518

  Fly   504 QVPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKL 568
            .:.|||||.....||::.||.|.|:..|..||...|.:.|:.||..:||||.|:...:::|: |:
Mouse   519 NIYPAELEDFFLKHPQVQEAQVVGVKDERMGEEICACIRLKSGETTTAEEIKAFCKGKISHF-KI 582

  Fly   569 EGGVIFVDEVPKNPTGKILRRELKEK 594
            ...::||:..|...:|||.:.:|:|:
Mouse   583 PRYIVFVEGYPLTISGKIQKFKLREQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	149/546 (27%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	143/524 (27%)
Acsf2	NP_722502.1	PRK08315	57..615	CDD:236236	149/546 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740