DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and DIP2

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster

Alignment Length:	658	Identity:	123/658 - (18%)
Similarity:	221/658 - (33%)	Gaps:	190/658 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 KWERRTAAVCVI---------TDRQYTFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYP 142
            :|...|:...:|         ..:..|.:::...:...|..||.:..::..|.:|:..|...:..
  Fly  1143 RWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALLQERGRIEPGDHVALIFPPGLDLL 1207

  Fly   143 IATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQASKLVGRQIPIAVVRT 207
            .|..|.:..|....|:.|.: |..:...|.         ||.....:|::..::..| ||..:..
  Fly  1208 CAFYGCLYLGAIPITIRPPH-PQNLNTTLP---------TVRMIVDVSKSGIVLSIQ-PIIKLLK 1261

  Fly   208 SAEEAL---PEGAIDFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNIT 269
            |.|.|.   |:......::......:|..:..   .|.|...:|.||..|.|...||.::|.:::
  Fly  1262 SREAATSIDPKTWPPILDIDDNPKRKYAGIAT---VSFDSSAYLDFSVSTCGRLSGVNITHRSLS 1323

  Fly   270 SNCEQVQ----------ASLPLD----------------------LMGP---------------- 286
            |.|..::          .:|.||                      |:.|
  Fly  1324 SLCASLKLACELYPSRHVALCLDPYCGLGFVMWTLIGVYSGHHSILIAPYEVEANPSLWLSTLSQ 1388

  Fly   287 --------------------QNTLPGV-----------------------------LPFFHIYGL 302
                                .|::|.:                             ...|...||
  Fly  1389 HRVRDTFCSYGVIELCTKALSNSIPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCKLFQALGL 1453

  Fly   303 TVVMLSKLGQGCRLATMPCFKPDDF---------MRSLDKYQGSILNLVPPIALFMINHPKLTQE 358
            ....:| ...|||:....|.:....         ||:|...:.:::....|.:|.:|...||
  Fly  1454 NTRCVS-TSFGCRVNPAICVQGASSAESAQVYVDMRALRNNRVALVERGAPNSLCVIESGKL--- 1514

  Fly   359 TAPHLKVVMS--------GAAPIGQ------HDVERFLNKFPNTVFKQGYGMTEASPVVLLTPEG 409
             .|.:||:::        |.:.:|:      |:...:.     |::.......:.....|:|...
  Fly  1515 -LPGVKVIIANPETKGHCGDSHLGEIWVQAPHNANGYF-----TIYGDETDYNDHFNAKLVTGAT 1573

  Fly   410 NKVYASTGVL------PASTEAKI-------VPLDGSDAKGVGPRTTGELCVRGPQVMAGYLNND 461
            :::||.||.|      ..|..|.:       |....||.:.:  .:..:|.:....|..|  .|.
  Fly  1574 SELYARTGYLGFLRRTECSQSASLLDETTPSVASRDSDTESL--NSISQLQLNFSNVSLG--GNS 1634

  Fly   462 EANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPAELE-AVLRDHPKILEAAV 525
            |.:.|    |....:.|...:|   ..|:...:.|:|.::|....|.::| :|:|.|.||.|.||
  Fly  1635 EHSLV----GGASNANDQELHD---AVYVVGAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAV 1692

  Fly   526 FGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLEGGVIFVDE---VPKNPTGKIL 587
            |...:..      .:||...|.::.|.::...|...|....:|..||:.|.:   ||.|..|:..
  Fly  1693 FTWTNLL------VVVVELDGNESEALDLVPLVTNTVLEDHQLIVGVVVVVDPGVVPINSRGEKQ 1751

  Fly   588 RRELKEKF 595
            |..|::.|
  Fly  1752 RMHLRDGF 1759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	122/656 (19%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	117/627 (19%)
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	77/467 (16%)
		AFD_class_I	1159..1762	CDD:302604	120/642 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900