DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and ACSBG1

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_016877514.1	Gene:	ACSBG1 / 23205	HGNCID:	29567	Length:	748	Species:	Homo sapiens

Alignment Length:	747	Identity:	168/747 - (22%)
Similarity:	263/747 - (35%)	Gaps:	243/747 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TTNRRQRTTSTASAQRERTQSVSETDKFLHYS------------PEDGYYKTSP-------FDPV 70
            ||..:.:|:|....|....:|::..   |..|            ||:..:.|..       .||
Human    36 TTQEKLKTSSLTDRQPLSKESLNHA---LELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDP- 96

  Fly    71 TIPNVP----------LHEY---VWRDFK---KWERRTAAVCVITDRQYTFAQMRDASAAFAVRL 119
            :.|.:|          |.:|   :...||   |||.       |:..|| :...|.|:..|
Human    97 SCPQLPYTVHRMFYEALDKYGDLIALGFKRQDKWEH-------ISYSQY-YLLARRAAKGF---- 149

  Fly   120 QTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVS 184
             .|..|::...:||...|.||:..:.:|.:.||..||.:....:| |..:.:.:.    ....|.
Human   150 -LKLGLKQAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSP-EACQYIAYD----CCANVI 208

  Fly   185 GFATLSQASKL--VGRQIP---------------IAVVRTSAE-----EALPEGAIDFSELTSTQ 227
            ...|..|..|:  :.:|:|               :|.|.|..|     ..:||.|:|  .:..||
Human   209 MVDTQKQLEKILKIWKQLPHLKAVVIYKEPPPNKMANVYTMEEFMELGNEVPEEALD--AIIDTQ 271

  Fly   228 NVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNITSNC---EQVQASLPLDLMGPQNT 289
            .        |.:...     |.::|||||.|||||||.:|||...   .|.....|.::.  |..
Human   272 Q--------PNQCCV-----LVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIRPAEVQ--QEV 321

  Fly   290 LPGVLPFFHIYGLTVVMLSKLGQGCRLATMPCFKPDDFMRSLDKYQGSILNL---VPPIALFMIN 351
            :...||..||    ...:..|..|.:.....||...|.::      ||::|.   |.|.:...:
Human   322 VVSYLPLSHI----AAQIYDLWTGIQWGAQVCFAEPDALK------GSLVNTLREVEPTSHMGV- 375

  Fly   352 HPKLTQETAPHLKVVMS------------------------------------------------ 368
             |::.::....::.|.:
Human   376 -PRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDLKPFTTRLADYLVLAKVRQA 439

  Fly   369 -----------GAAPIGQHDVERFLNKFPNTVFKQGYGMTEAS-PVVLLTPEGNKVYASTGVLPA 421
                       ||||:.......||..  |.....|||::|.| |..:.:|...::|:|..::|.
Human   440 LGFAKCQKNFYGAAPMMAETQHFFLGL--NIRLYAGYGLSETSGPHFMSSPYNYRLYSSGKLVPG 502

  Fly   422 STEAKIVPLDGSDAKGVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDG 486
            ..    |.|...||:|:     ||:|:.|..:..||||.::..........||.:||....|.||
Human   503 CR----VKLVNQDAEGI-----GEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDADG 558

  Fly   487 LFYITDRMKELIKVKGFQ-VPPAEL-EAVLRDHPKILEAAVFGIPHEF----------------- 532
            ..|||.|:||||...|.: |||..: |||..:.|.|..|.:.|...:|
Human   559 FLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSD 623

  Fly   533 ----------------NGEAPRAIVVLRQGEKA---SAEE----ISAYVAERVAHYKK------- 567
                            ...|.....::.:.::|   :.||    ::...|.|..|.:|
Human   624 QTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQAIEEGIRRVNMNAAARPYHIQKWAILERD 688

  Fly   568 --LEGGVIFVDEVPKNPTGKILRRELKEKFSD 597
              :.||.:       .||.|:.|..:.||:.|
Human   689 FSISGGEL-------GPTMKLKRLTVLEKYKD 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	151/662 (23%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	141/626 (23%)
ACSBG1	XP_016877514.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148975
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930