DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and ACSL1

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001273637.1	Gene:	ACSL1 / 2180	HGNCID:	3569	Length:	698	Species:	Homo sapiens

Alignment Length:	704	Identity:	159/704 - (22%)
Similarity:	262/704 - (37%)	Gaps:	169/704 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TAFGSAATRSITT--------------NRRQRTTSTASAQRERTQSVSETDKFLHYSPED----- 59
            |..|..|..::||              :...::...|.:...|..::.::|:.|.|..:|
Human    29 TLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLY 93

  Fly    60 -GYYK---TSPFDPVTIPNVPLHEYVWRDFKKWERRTAAVCVITDRQYTFAQMRDASAAF-AVRL 119
             |:.:   .|...|......|...|.|..:|                    |:.:.|... :..:
Human    94 EGFQRGIQVSNNGPCLGSRKPDQPYEWLSYK--------------------QVAELSECIGSALI 138

  Fly   120 QTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQ-LTFSGAKFLVGTV 183
            |..|.......:.|...|.||:.|...|.....:.:.   |:|  |.:..: :|:...|..:..|
Human   139 QKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIV---PLY--DTLGNEAITYIVNKAELSLV 198

  Fly   184 SGFATLSQASKLV-----GRQIP----IAVVRTSAEEALPEGAIDFSELTSTQNVRYEDL----- 234
              |....:.:||:     .:.||    |.|:.....|.:..|.....|:||.:.:  |||
Human   199 --FVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAM--EDLGRANR 259

  Fly   235 KAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNITSNCEQ-VQASLPLDLMGPQNTLPGVLPFFH 298
            :.||..:.:|:..:.|:|||||.|||.|::|.||.|:|.. |:|:.......|.:||...||..|
Human   260 RKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAH 324

  Fly   299 IYGLTV--VMLSKLGQGCRLATMPCFKPDD--FMRSLDKYQGSILNLVPPI------ALF----- 348
            ::...|  |||      |..|.:..|:.|.  .|..|...|.::..:||.:      .:|
Human   325 MFERVVECVML------CHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANT 383

  Fly   349 -------------------------------MINHPKLTQETAPHLKVVMSGAAPIGQHDVERFL 382
                                           :|.| |:.......::::::||||:.. .|..||
Human   384 TLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFH-KVQSSLGGRVRLMVTGAAPVSA-TVLTFL 446

  Fly   383 NKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVPLDGSDAKGVGPRTTGELC 447
            .......|.:|||.||.:....||..|:......|........|:|  |..:...:.....||:|
Human   447 RAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLV--DVEEMNYMAAEGEGEVC 509

  Fly   448 VRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKV-KGFQVPPAELE 511
            |:||.|..|||.:............||.:||:..:..:|...|.||.|.:.|: :|..:.|.::|
Human   510 VKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIE 574

  Fly   512 AV-LRDHPKILEAAVFGIPHEFNGEAPRAIVVL--------------RQGEKASAEE------IS 555
            .: :|..|   .|.||     .:||:.:|.::.              ::|.:.|.||      :.
Human   575 NIYMRSEP---VAQVF-----VHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVK 631

  Fly   556 AYVAERVAHYKKLEG--------GVIF------VDEVPKNPTGKILRRELKEKF 595
            ..:.|.:....|..|        |:..      :|.....||.|..|.||:..|
Human   632 KAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYF 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	143/616 (23%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	137/586 (23%)
ACSL1	NP_001273637.1	LC-FACS_euk	116..694	CDD:341250	144/617 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930