DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and acs-1

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001023937.1	Gene:	acs-1 / 179043	WormBaseID:	WBGene00018488	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	138/548 - (25%)
Similarity:	239/548 - (43%)	Gaps:	55/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ERRTAAVCVITDRQY----------TFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPI 143
            :|..:||..:.|:::          |::|:...:...|..| ....|:|.|.:.|..||..|:..
Worm    70 DRLRSAVDQVPDKEFLIFKREGIRKTYSQVATDAENLACGL-LHLGLKKGDRIGIWGPNTYEWTT 133

  Fly   144 ATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGF---------------ATLSQAS 193
            ....:..||:.:..:||.|..:|:...:...|.:.|: |..||               .||.:..
Worm   134 TQFASALAGMVLVNINPSYQSEELRYAIEKVGIRALI-TPPGFKKSNYYQSIKDILPEVTLKEPG 197

  Fly   194 K--LVGRQIPI--AVVRTSAEEALPEGAIDFSEL--TSTQNVRYEDLKAPKEASADDMVFLPFSS 252
            |  :..|....  .::....|:.:..||..::::  ..|:..|:...|..:|...||.:.:.::|
Worm   198 KSGITSRNFTCFQHLIMFDEEDKIYPGAWKYTDVMKMGTEEDRHHLSKIERETQPDDSLNIQYTS 262

  Fly   253 GTTGLPKGVMLSHNNITSNCEQVQASLPLDLMGPQNTLPGVLPFFHIYGLTVVMLSKLG--QGCR 315
            ||||.|||..|:|:|:.:|...|..............:|.  |.:|.:|..:.:|:.|.  |.|
Worm   263 GTTGQPKGATLTHHNVLNNAFFVGLRAGYSEKKTIICIPN--PLYHCFGCVMGVLAALTHLQTC- 324

  Fly   316 LATMPCFKPDDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLKVVMSGAAPIGQHDVER 380
            :...|.|.....::::.:.:.:.|...|.:.:.|||||:........::......||.......|
Worm   325 VFPAPSFDALAALQAIHEEKCTALYGTPTMFIDMINHPEYANYNYDSIRSGFIAGAPCPITLCRR 389

  Fly   381 FLNKFPNTVFKQGYGMTEASPVVLLT----PEGNKVYASTGVLPASTEAKIVPLDGSDAKG-VGP 440
            .:.....|..:..||.||.|||..::    |...:: .|.|.:....||.||     |.:. :.|
Worm   390 LVQDMHMTDMQVCYGTTETSPVSFMSTRDDPPEQRI-KSVGHIMDHLEAAIV-----DKRNCIVP 448

  Fly   441 R-TTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQ 504
            | ..||:.|||..||..|.|::|..:.......|..:||:|...::|...|..|.|::|...|..
Worm   449 RGVKGEVIVRGYSVMRCYWNSEEQTKKEITQDRWYHTGDIAVMHDNGTISIVGRSKDMIVRGGEN 513

  Fly   505 VPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGE--KASAEEISAYVAERVAHYKK 567
            :.|.|:|..|..|..:.:..:.|:|.|..||...|.|.|.:..  |.:.|:|.|:...::||: |
Worm   514 IYPTEVEQFLFKHQSVEDVHIVGVPDERFGEVVCAWVRLHESAEGKTTEEDIKAWCKGKIAHF-K 577

  Fly   568 LEGGVIFVD--EVPKNPTGKILRRELKE 593
            :...::|..  |.|...|||:.:.|::|
Worm   578 IPRYILFKKEYEFPLTVTGKVKKFEIRE 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	138/548 (25%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	133/530 (25%)
acs-1	NP_001023937.1	PRK08315	53..615	CDD:236236	138/548 (25%)
acs-1	NP_001023937.1	FACL_like_2	252..604	CDD:213284	100/361 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.790