DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and acs-6

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_495450.1	Gene:	acs-6 / 174156	WormBaseID:	WBGene00022849	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	172/532 - (32%)
Similarity:	267/532 - (50%)	Gaps:	60/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 AVCVI----TDRQYTFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLT 154
            |||.|    |.::..:..:.....:.|..| .|...:..||.:...||.||:.:|.|..::.|..
Worm    35 AVCFIDAETTTKKKLYKDVEPTVNSLATAL-VKLGFKPGDVASQAFPNCPEFLVAMLAVMKCGGA 98

  Fly   155 VTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQA-SKLVG-------RQIPIAVVRTSAEE 211
            ::..:.::|..|:..|...|....:.......|.:.:| :|..|       |..|:   ||.
Worm    99 MSNASAIFTDYELQLQFCDSNTSIVFTDEDRLARIRRATAKCPGVRKIICLRTFPL---RTE--- 157

  Fly   212 ALPEGAIDFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNITSNCEQVQ 276
             .||..:|:.|||.|     .|.......|.|.:..||:||||||.|||..|:|.||.:..:..:
Worm   158 -FPENVLDYVELTQT-----PDQPINVNVSMDSIALLPYSSGTTGRPKGCQLTHRNIGAMLDVAK 216

  Fly   277 ASLPLD----LMG-------PQNTLPGVLPFFHIYGL-TVVMLSKLGQGCRLATMPCFKPDDFMR 329
            |.|..|    :.|       .::|:. :||::|.||| |:.....||.     |...||..|.:.
Worm   217 AHLETDVAPAMFGKEKATWHKEHTVL-LLPWYHAYGLNTMFETILLGM-----TGIVFKKFDTIV 275

  Fly   330 SLDK---YQGSILNLVPPIALFMINHPKL-TQETAPHLKVVMSGAAPIGQHDVERFLNKFPNTVF 390
            .|::   |:..:..||||:.:|:...|.: ...|||.|||:||..|..|:...|....:|||...
Worm   276 MLNRIKFYKVKLAWLVPPMLIFLAKDPMVPIFNTAPFLKVIMSAGATAGKQLCEEVSKRFPNAWL 340

  Fly   391 KQGYGMTEASPVVLLTP----EGNKVYASTGVLPASTEAKIVPLDGSDAKGVGPRTTGELCVRGP 451
            .|.|||||   :|..|.    |....:.:.|.|.::.|.||:..:..:...:  .|.|:||.|||
Worm   341 CQAYGMTE---MVQFTTIPRFEDGNCFETVGNLASTYELKILDKEKKEITTI--NTVGQLCFRGP 400

  Fly   452 QVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPAELEAVLRD 516
            .||.|||..:||:.:.  ...:|.:||:...|:.|..::|.|:||||||.|.||||.|:|.||..
Worm   401 TVMKGYLKREEADIID--KDGFLLTGDLGSIDDKGRIHVTGRIKELIKVNGMQVPPVEIEDVLLL 463

  Fly   517 HPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLEGGVIFVDEVPKN 581
            |||:.:.||.|:|.|..||:|:|.:| ::....:..|::.:|.::::.||.:: ...|:|.:||.
Worm   464 HPKVKDCAVIGVPDEHKGESPKAYIV-KKDHTLTEAELTEFVRQKLSSYKWID-TYEFIDSIPKL 526

  Fly   582 PTGKILRRELKE 593
            |:|||.|::||:
Worm   527 PSGKIQRKKLKK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	172/532 (32%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	164/515 (32%)
acs-6	NP_495450.1	CaiC	15..541	CDD:223395	172/532 (32%)
acs-6	NP_495450.1	Firefly_Luc_like	37..532	CDD:213279	166/522 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54045
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.790