DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and AgaP_AGAP000907

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_316885.5	Gene:	AgaP_AGAP000907 / 1277421	VectorBaseID:	AGAP000907	Length:	553	Species:	Anopheles gambiae

Alignment Length:	573	Identity:	163/573 - (28%)
Similarity:	248/573 - (43%)	Gaps:	85/573 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SPFDPVT-------IP-----NVPLHEYVWRDFKKWERRTAAVCVITD---RQYTFAQMRDASAA 114
            |.:||||       .|     |..|.:.|....::.:  .|.|..|:|   |..|..:|...:..
Mosquito    12 SYYDPVTHIWTGLSTPPLFNTNQSLGQLVLGVLQRCD--PAQVTQISDDGGRTVTCREMYLRTVR 74

  Fly   115 FAVRL-QTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKF 178
            .|.|| |..:....| :.|:...|..............|:.:.|::..:...:.|..
Mosquito    75 IAERLAQLGYGKHTP-MAALASRNGEHVAPVAFACFALGIPINTLDTAFNVADFAHM-------- 130

  Fly   179 LVGTVSGFATLSQASKLVGRQIPIAVVRTSAEEA--LPE------------GAIDFSELTSTQNV 229
                   |.....|.......| :.|||.:|:.|  .||            ..:|..|.|.|
Mosquito   131 -------FGVTRPALVFCESDI-LEVVREAAQRAAIAPEIVLFEERTAGYRHVLDLLEPTGT--- 184

  Fly   230 RYEDLKAPKEASADD----MVFLPFSSGTTGLPKGVMLSHNNITSNCEQVQASLPLDLMGPQNTL 290
              ||...|  .:.||    :..:..|||||||.|||..:|....:|...:....|.|.:
Mosquito   185 --EDSFVP--TNLDDPTTHVAAVLCSSGTTGLSKGVTYTHTFCIANLPSLWRMAPTDCL------ 239

  Fly   291 PGVLPFFHIY---GLTVVMLSKLGQGCRLATMPCFKPDDFMRSLDKYQGSILNLVPPIALFMINH 352
               |.|..:|   |...:::..:.|..|:.|...|.|...:..|.::..:|....|..:..:::.
Mosquito   240 ---LAFSSLYWLSGFASLIIGTVSQAARVITRAPFTPTLALDMLQRHPVTIAFFSPFQSNLLVHE 301

  Fly   353 PKLTQETAPHLKVVMSGAAPIGQHDVERFLNKFP-NTVFKQGYGMTEASPVVLLTPEGNKVYAS- 415
            |.|.|...|.|::.:.|.|.:.:..........| :|..:.||||:| |.:|.|| :||. |..
Mosquito   302 PLLAQTPLPALRLFLCGGARVSKQLYAALQRCLPSHTRIQIGYGMSE-SCLVTLT-DGNS-YRDD 363

  Fly   416 -TGVLPASTEAKIVPLDGSDAKGVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDV 479
             .|.|.|..||:||. ||.|..|:.|...||:.:|.....|||..|.:|......|..|:|:||:
Mosquito   364 CVGTLQARVEARIVD-DGLDQCGLAPDEPGEIMLRVQIPFAGYYGNPDATAELMSPDGWIRTGDI 427

  Fly   480 AFYDEDGLFYITDRMKELIKVKGFQVPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLR 544
            .::|.||..|:.||.|::||..|.|:.|.|||.:.:....:|:..|.|:|.|  |....|.:|||
Mosquito   428 GYFDRDGHLYVIDRKKDIIKYAGNQISPTELEVLAKQLTGVLDCCVVGVPDE--GTDLPAALVLR 490

  Fly   545 Q----GEKASAEEISAYVAERVAHYKKLEGGVIFVDEVPKNPTGKILRRELKE 593
            :    |...:|:::..:|.|||:.:|.|.|||.|.:|:|..|:|||:||:..|
Mosquito   491 EPGATGAALTADQVRQFVDERVSAHKHLRGGVYFTEEMPLTPSGKIVRRKCLE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	156/549 (28%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	147/519 (28%)
AgaP_AGAP000907	XP_316885.5	CaiC	49..543	CDD:223395	153/532 (29%)
AgaP_AGAP000907	XP_316885.5	AFD_class_I	54..536	CDD:302604	147/520 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820