DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and AgaP_AGAP004655

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_316739.3	Gene:	AgaP_AGAP004655 / 1277297	VectorBaseID:	AGAP004655	Length:	548	Species:	Anopheles gambiae

Alignment Length:	532	Identity:	178/532 - (33%)
Similarity:	268/532 - (50%)	Gaps:	52/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 KKWERRTAAVCVITDRQYT----FAQMRDASAAFAVRLQTKFNLQKPDVLAICLPNLPEYPIATL 146
            |:..|....|.|| |..|:    :.::.:.:...|..|::..::....|:.|...|..|:|:...
Mosquito    34 KRLLRHGDGVAVI-DGVYSNELRYLELLENAVRLAEGLRSLTDVTPNGVVGIISENRLEFPVVLY 97

  Fly   147 GAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQASKLVGRQIPIAVVRTSA-- 209
            .:......|..:|..||..|....|..|....|      |.:...|.::      |||.|.:.
Mosquito    98 ASFFVNAAVAPINLTYTEREFDHALNLSKPSIL------FVSPYSAERV------IAVARKNRHF 150

  Fly   210 ---------EEALPEGAI---DFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGVM 262
                     |.:.....:   ||...||..| .|....||.... :.:..:..|||||||||||.
Mosquito   151 IKHIFLFGNENSFGADVVLFNDFLLQTSAIN-PYSFQVAPTNVE-EHVALIMCSSGTTGLPKGVQ 213

  Fly   263 LSHNNI---TSNCEQVQASLPLDLMGPQNTLPGVLPFFHIYG-LTV--VMLSKLGQGCRLATMPC 321
            |:..|:   .|....::||..:.::     :.||:|:||.:| ||:  |:.:||    :|.::|.
Mosquito   214 LTQRNVIASVSLLSVLEASFEVPVV-----VLGVIPWFHAFGCLTLINVICNKL----KLVSLPK 269

  Fly   322 FKPDDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLKVVMSGAAPIGQHDVERFLNKFP 386
            |:...|:..::.|:.|.:.:|||:.:|:..||.:.......:..::.||||:.: :.|..:.|..
Mosquito   270 FEEGLFLSCIENYRCSFVFVVPPLMVFLAKHPLVDNYDLSCINTLLCGAAPLSK-ETEMLVKKRI 333

  Fly   387 NTV-FKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVPLDGSDAKGVGPRTTGELCVRG 450
            ... ..|||||:|.:..:|:....:....|.|.|.|.|.||:|  |....:.:||...|||..:|
Mosquito   334 GVKHVLQGYGMSETTLAMLIQSNDSNKSGSVGKLQAGTMAKVV--DVETGRLLGPNEAGELYFKG 396

  Fly   451 PQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVPPAELEAVLR 515
            .|:|.||:.|::....|.....|||:||:.:||.|..|:|.||:|||||.||:||||||:||||.
Mosquito   397 TQIMKGYIGNEQETIQTIDKDGWLRTGDIGYYDNDEEFFIIDRLKELIKYKGYQVPPAEIEAVLL 461

  Fly   516 DHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLEGGVIFVDEVPK 580
            .:.||.:|.|.|.|.|..||.|.|.||.:.|...:.||:..|||.|.:..|:|.|||.||.|:||
Mosquito   462 TNSKIKDAGVVGFPDEAAGELPLAFVVKQPGVTLTEEEVKQYVAARTSPAKRLHGGVRFVSEIPK 526

  Fly   581 NPTGKILRRELK 592
            |.:||||||||:
Mosquito   527 NVSGKILRRELR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	178/532 (33%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	167/512 (33%)
AgaP_AGAP004655	XP_316739.3	PLN02246	27..541	CDD:215137	178/532 (33%)
AgaP_AGAP004655	XP_316739.3	Firefly_Luc_like	44..533	CDD:213279	169/515 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54045
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830