DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdgy and AgaP_AGAP002503

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_312436.5	Gene:	AgaP_AGAP002503 / 1273459	VectorBaseID:	AGAP002503	Length:	589	Species:	Anopheles gambiae

Alignment Length:	542	Identity:	213/542 - (39%)
Similarity:	310/542 - (57%)	Gaps:	29/542 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SPFDPVTIPNVPLHEYVWRDFKKWERRTAAVCVITDRQYTFAQMRDASAAFAVRL--QTKFNLQK 127
            |||..|.||...:.||::..::|:..:.|..|..:.|.||:....:.....|..|  |....:::
Mosquito    53 SPFGSVDIPEKNVTEYIFEGYEKYADKPAITCGASKRSYTYGMTYEMVKRMACGLLSQKGCAMRQ 117

  Fly   128 PDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQ- 191
            .|||.:.|||:||:..|..|.:.||||||..||:||.:|:.||...:|...:| ||.....:::
Mosquito   118 HDVLGLLLPNIPEFVPALHGGLLAGLTVTFANPLYTAEEVCRQFENAGVTAIV-TVPMLLPVAEM 181

  Fly   192 -ASKLVGRQIPIAVVRTSAEEALPEGAIDFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTT 255
             .||:...:..|.:   ..:..|.:....|.:... :|.|.|   .| |........||:|||||
Mosquito   182 FKSKMKHYKGTICI---GGKHDLDKNIYGFEQFLK-ENHRSE---LP-EIDCHKTAILPYSSGTT 238

  Fly   256 GLPKGVMLSHNNITSNCEQVQASLPL-------DLMGPQNTLPGVLPFFHIYGLTVVMLSKLGQG 313
            ||||||.|||.|:.:|.  .|.|.|.       :.:..:.|:..:.||||||||..::...|...
Mosquito   239 GLPKGVELSHYNLVANL--AQGSHPAISKYYQPEYLEKKETILTIPPFFHIYGLNGILHMVLKSK 301

  Fly   314 CRLATMPCFKPDDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLKVVMSGAAPIGQHDV 378
            ..:.::|.|.|:|:::.|.:::...|.:||.:.||:..|||:|.:....:..|:.||||......
Mosquito   302 NHVVSIPRFIPEDYIQCLAEFRPQFLFVVPSLLLFLATHPKVTPDLLSSVDSVLVGAAPASLQLQ 366

  Fly   379 ERFLNKFPNTV-FKQGYGMTEASPVVLLTP---EGNKVYASTGVLPASTEAKIVPLDGSDAKGVG 439
            |:|.||....: ..|||||||:|||.|.||   :.:|| .:.|.|..:||||||.|  ||...:|
Mosquito   367 EKFKNKVGRDIDIAQGYGMTESSPVTLCTPHRYDLSKV-GTCGQLYPNTEAKIVSL--SDGSNLG 428

  Fly   440 PRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQ 504
            |..||||.:||||:|.|||||:.|.:.|.....:||:||||:||::|.|:|.||.||||||||.|
Mosquito   429 PHQTGELYLRGPQIMKGYLNNETATRETLVEDGYLRTGDVAYYDKEGFFFIVDRTKELIKVKGNQ 493

  Fly   505 VPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEKASAEEISAYVAERVAHYKKLE 569
            |.|.|||.::.:.|::.:.||.|:|.|..||.|||.||::.|.:....|:..||.|||..||:|.
Mosquito   494 VSPTELENIILELPEVSDVAVAGVPDETAGELPRAFVVVKPGSQLDEREVQDYVKERVVKYKQLA 558

  Fly   570 GGVIFVDEVPKNPTGKILRREL 591
            |||:|:.|:|:|..||::|::|
Mosquito   559 GGVVFIKEIPRNAAGKVVRQQL 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	207/530 (39%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	200/502 (40%)
AgaP_AGAP002503	XP_312436.5	CaiC	61..580	CDD:223395	207/532 (39%)
AgaP_AGAP002503	XP_312436.5	AFD_class_I	81..575	CDD:302604	201/507 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
TreeFam	0	0.000	Not matched by this tool.
	5	4.820