DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdgy and Acsl6

DIOPT Version :9

Sequence 1:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_006246283.2	Gene:	Acsl6 / 117243	RGDID:	69403	Length:	722	Species:	Rattus norvegicus

Alignment Length:	712	Identity:	146/712 - (20%)
Similarity:	239/712 - (33%)	Gaps:	194/712 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNPAAQLLRMRSATAFGSAATRSITTNRRQRTTSTASAQR------ERTQSVSETDKFLHYSPED 59
            :.|...||...........|.||:..:..|..|......|      .|..|:|.....|
  Rat    76 LQPPCNLLMQSEEVEDSGGARRSVIGDCTQLLTHYYDDARTMYQVFRRGLSISGNGPCL------ 134

  Fly    60 GYYKTSPFDPVTIPNVPLHEYVWRDFKKWERRTAAV--------CVITDRQY--TFAQMRDASAA 114
            |:.|            |...|.|..:::..:|...:        |.:...|:  .|||
  Rat   135 GFRK------------PEQPYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFIGVFAQ------- 180

  Fly   115 FAVRLQTKFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFL 179
                                  |.||:.||.|......:.|..:.....|..|         :::
  Rat   181 ----------------------NRPEWIIAELACYTYSMVVVPLYDTLGPGSI---------RYI 214

  Fly   180 VGTV-----------SGFATLSQASKLVGRQIPIAVVRTSAEEALPEG----AIDFSELTSTQNV 229
            :.|.           .....|....:.....:.:.::....::||.|.    .:|...:.:.::.
  Rat   215 INTADICTVIVDKPHKAILLLEHVERKETPGLKLVILMEPFDDALRERGKKCGVDIKSMQAIEDS 279

  Fly   230 RYEDLKAPKEASADDMVFLPFSSGTTGLPKGVMLSHNNITSNCEQVQASLPLDLMG--------- 285
            ..|:.:.|.....||:..:.|:|||||.|||.||:|.|:.:           |..|
  Rat   280 GQENHRVPVPPRPDDLSIVCFTSGTTGNPKGAMLTHGNVVA-----------DFSGFLKVTEKVI 333

  Fly   286 ---PQNTLPGVLPFFHIYGLTVVML-----SKLG--QG-CRLAT--MPCFKPDDF-------MRS 330
               ..:.|...||..|::...:..:     .::|  || .||.:  |...:|..|       .|.
  Rat   334 FPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALRPTIFPVVPRLLNRM 398

  Fly   331 LDKY-------------------------QGSILNLVPPIALFMINHPKLTQETAPHLKVVMSGA 370
            .||.                         .|.|.|......||.   .|:......|::::::||
  Rat   399 YDKIFHQADTSLKRWLLEFAAKRKQAEVRSGIIRNNSIWDELFF---NKIQASLGGHVRMIVTGA 460

  Fly   371 APIGQHDVERFLNKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVPLDGSDA 435
            || ....|..||.........:|||.||.:.....|..|:......|........|:|     ||
  Rat   461 AP-ASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLV-----DA 519

  Fly   436 KGVGPRTT---GELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYDEDGLFYITDRMKEL 497
            :.:...|:   ||:||:||.|..|||.:::..:.......||.:||:..:..:|...|.||.|.:
  Rat   520 EELNYWTSKGEGEICVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHI 584

  Fly   498 IKV-KGFQVPPAELEAV-LRDHP--------KILEAAVFGI----PHEFNGEAPRAIVVLRQGEK 548
            .|: :|..|.|.::|.: :|..|        ..|:|.:.||    |......|.:..:.....|.
  Rat   585 FKLAQGEYVAPEKIENIYIRSEPVAQIYVHGDSLKAFLVGIVVPDPEVMPCWAQKKGIEGNYQEL 649

  Fly   549 ASAEEISAYVAERVAHYKKLEGGVIFVDEVPK---------------NPTGKILRRELKEKF 595
            ..::|:...:.:.:....| |.|:...::|..               .||.|..|.||:|.|
  Rat   650 CKSKELKKAILDDMVMLGK-ESGLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELREYF 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	129/628 (21%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	121/590 (21%)
Acsl6	XP_006246283.2	LC-FACS_euk	141..719	CDD:341250	130/629 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930