DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Flo2 and Flot1

DIOPT Version :9

Sequence 1:	NP_001259553.1	Gene:	Flo2 / 32425	FlyBaseID:	FBgn0264078	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_073192.2	Gene:	Flot1 / 64665	RGDID:	70991	Length:	428	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	184/440 - (41%)
Similarity:	281/440 - (63%)	Gaps:	30/440 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TTGPNEALIVSGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLNVMTLNPMCENVETSQGVPLTVT 70
            |.|||||::|||.|  .:....:.||..:....:..:||:|||.:|||...|.|.|..|||::||
  Rat     4 TCGPNEAMVVSGFC--RSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVT 66

  Fly    71 GVAQCKIMKSSSYKQTDYHNDEMMNVYYFHHQADELLGTASEQFLGKSVKEIKQTILQTLEGHLR 135
            |:||.||                      ..|..|:|..|.:.||||:..||....|:|||||.|
  Rat    67 GIAQVKI----------------------QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQR 109

  Fly   136 AILGTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLASLGKAQTAVVKR 200
            ||:..:||||:||||.:|:..|.:||:.|:..|||.::|:|:||::||..||.|||||:||.|::
  Rat   110 AIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQK 174

  Fly   201 DADAGVAEANRDAGIREAECEKSAMDVKYSTDTKIEDNTRMYKLQKANFDQEINTAKAESQLAYE 265
            ||..|.|||.||||||||:.::..:..:..::.::....|.|:|:||.:|.|:||.:|::.|||:
  Rat   175 DARIGEAEAKRDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYELKKATYDIEVNTRRAQADLAYQ 239

  Fly   266 LQAAKIRQRIRNEEIQIEVVERRKQIEIESQEVQRKDRELTGTVKLPAEAEAFRLQTLAQAKQCQ 330
            ||.||.:|:|..:.:|::||||.:|:.::.||:.|:::||...|:.|||||.:||:.||:|::.|
  Rat   240 LQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYRLERLAEAEKAQ 304

  Fly   331 TIEGARAEAERIRKIGSAEAHAIELVGKAEAERMRMKAHVYKQYGDAAIMNIVLESLPKIAAEVA 395
            .|..|.||||.:|..|.|||.|:....:||||:|..||..::.|.:||.::::||.||::|.|::
  Rat   305 LIMQAEAEAESVRMRGEAEAFAVGARARAEAEQMAKKAEAFQMYQEAAQLDMLLEKLPQVAEEIS 369

  Fly   396 APLAKTDEIVLIG------GNDNITNDVTRLVAQLPPSINALTGVDLSKV 439
            .||...::|.|:.      |...:|.:|..::::||.|:..||||.:|:|
  Rat   370 GPLTSANKITLVSSGSGTMGAAKVTGEVLDILSRLPESVERLTGVSISQV 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Flo2	NP_001259553.1	SPFH_flotillin	34..201	CDD:259798	72/166 (43%)
		PHB	110..281	CDD:214581	81/170 (48%)
		SPFH_like	<286..374	CDD:302763	39/87 (45%)
		Flot	337..>410	CDD:292597	30/78 (38%)
Flot1	NP_073192.2	YqiK	4..424	CDD:225177	184/440 (42%)
Flot1	NP_073192.2	SPFH_flotillin	30..175	CDD:259798	72/166 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2268
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D340567at33208
OrthoFinder	1	1.000	-	-		FOG0001627
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820