DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Flo2 and flot1a

DIOPT Version :9

Sequence 1:	NP_001259553.1	Gene:	Flo2 / 32425	FlyBaseID:	FBgn0264078	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_570988.1	Gene:	flot1a / 561345	ZFINID:	ZDB-GENE-020430-1	Length:	438	Species:	Danio rerio

Alignment Length:	442	Identity:	192/442 - (43%)
Similarity:	286/442 - (64%)	Gaps:	30/442 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HTTGPNEALIVSGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLNVMTLNPMCENVETSQGVPLTV 69
            :|.|||||::|||.|  .:....|.||..:.:..|..:||:|||.:|||...:.|.|..|||::|
Zfish     3 YTCGPNEAMVVSGFC--RSPPVMISGGRVFVFPCVQQIQRISLNTLTLNVKSDKVYTRHGVPISV 65

  Fly    70 TGVAQCKIMKSSSYKQTDYHNDEMMNVYYFHHQADELLGTASEQFLGKSVKEIKQTILQTLEGHL 134
            ||:||.||                      ..|..::|..|.:.|||||..||....|:|||||.
Zfish    66 TGIAQMKI----------------------QGQNKQMLAAACQMFLGKSDSEIAHIALETLEGHQ 108

  Fly   135 RAILGTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLASLGKAQTAVVK 199
            |||:..|||||:||||.:|:..|.:||:.|:..|||.::|:|:|||:||..||.|||||:||.|:
Zfish   109 RAIIAHLTVEEIYKDRKKFSEQVFKVASSDLVNMGISVVSYTLKDVHDDQDYLHSLGKARTAQVQ 173

  Fly   200 RDADAGVAEANRDAGIREAECEKSAMDVKYSTDTKIEDNTRMYKLQKANFDQEINTAKAESQLAY 264
            :||..|.|:..|||.||||...:..:..:|..:.::....|.|:|:||.:|.|:.|.||||::||
Zfish   174 KDARIGEAKNKRDAVIREAHAMQEKVSAQYMNEIEMAKAQRDYELKKAIYDIEVFTKKAESEMAY 238

  Fly   265 ELQAAKIRQRIRNEEIQIEVVERRKQIEIESQEVQRKDRELTGTVKLPAEAEAFRLQTLAQAKQC 329
            :||.||.:|||..|::|:.||||.:||.::.||:.||::||...||.|||||.:||:.||:|::.
Zfish   239 QLQVAKTKQRIEEEKMQVLVVERSQQITLQEQEISRKEKELEAKVKKPAEAERYRLEKLAEAERL 303

  Fly   330 QTIEGARAEAERIRKIGSAEAHAIELVGKAEAERMRMKAHVYKQYGDAAIMNIVLESLPKIAAEV 394
            |.|..|.||||.||..|.|||:|:|..|:||||:|..||..::.|.:.|:::::||.||.:|.|:
Zfish   304 QLIMEAEAEAESIRVRGEAEAYAVEAKGRAEAEQMAKKAEAFQHYKEGAMVDMLLEKLPMMADEI 368

  Fly   395 AAPLAKTDEIVLI--GGND----NITNDVTRLVAQLPPSINALTGVDLSKVL 440
            :.||:.|:::.::  ||::    .:|.:|..::.:||.:|..||||::|:.:
Zfish   369 SKPLSATNKVTMVSSGGSEIGAAKLTGEVLDIMTKLPETIEKLTGVNISQCI 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Flo2	NP_001259553.1	SPFH_flotillin	34..201	CDD:259798	74/166 (45%)
		PHB	110..281	CDD:214581	85/170 (50%)
		SPFH_like	<286..374	CDD:302763	45/87 (52%)
		Flot	337..>410	CDD:292597	32/74 (43%)
flot1a	NP_570988.1	YqiK	4..425	CDD:225177	192/441 (44%)
		SPFH_flotillin	30..175	CDD:259798	74/166 (45%)
		SPFH_like	<241..337	CDD:302763	51/95 (54%)
		Flot	308..>385	CDD:292597	32/76 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D340567at33208
OrthoFinder	1	1.000	-	-		FOG0001627
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920