DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Flo2 and flot2

DIOPT Version :9

Sequence 1:	NP_001259553.1	Gene:	Flo2 / 32425	FlyBaseID:	FBgn0264078	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001011034.1	Gene:	flot2 / 496443	XenbaseID:	XB-GENE-5910825	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	451	Identity:	281/451 - (62%)
Similarity:	352/451 - (78%)	Gaps:	26/451 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNIHTTGPNEALIVSGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLNVMTLNPMCENVETSQGV 65
            |||.||.||||||:||||||||..|:.:.||||||||.|:|.||:||.:|||.|.|::|||::||
Frog     1 MGNCHTVGPNEALVVSGGCCGSDTKQYVYGGWAWAWWCVSDTQRISLEIMTLQPKCDDVETAEGV 65

  Fly    66 PLTVTGVAQCKIMKSSSYKQTDYHNDEMMNVYYFHHQADELLGTASEQFLGKSVKEIKQTILQTL 130
            .||||||||.|||...                       |||..||||||||:|.|||..:||||
Frog    66 ALTVTGVAQVKIMTER-----------------------ELLAVASEQFLGKNVHEIKNVVLQTL 107

  Fly   131 EGHLRAILGTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLASLGKAQT 195
            |||||:||||||||::|:||||||.|||||||||||||||||||||||||||.|:||:||||:||
Frog   108 EGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVEYLSSLGKSQT 172

  Fly   196 AVVKRDADAGVAEANRDAGIREAECEKSAMDVKYSTDTKIEDNTRMYKLQKANFDQEINTAKAES 260
            |.|:||||.|||||.||||||||.|::..:||||..|||:.|:.|.:::|||.|.||:||.|||:
Frog   173 AAVRRDADIGVAEAERDAGIREALCKRETLDVKYLADTKMADSKREFEMQKAGFSQEVNTKKAEA 237

  Fly   261 QLAYELQAAKIRQRIRNEEIQIEVVERRKQIEIESQEVQRKDRELTGTVKLPAEAEAFRLQTLAQ 325
            ||||||||||.:|:||.|||:||||:|:|||:||.:|:.|.|:||..||:.||||||:|:|.:|:
Frog   238 QLAYELQAAKEQQKIRQEEIEIEVVQRKKQIDIEEKEIVRMDKELIATVRRPAEAEAYRMQQIAE 302

  Fly   326 AKQCQTIEGARAEAERIRKIGSAEAHAIELVGKAEAERMRMKAHVYKQYGDAAIMNIVLESLPKI 390
            .::.:.:..|:||||:|||||.|||..||.:||||||:|::||..|:|||:||.|.:|||.||:|
Frog   303 GEKVKQVLYAQAEAEKIRKIGDAEAATIEAIGKAEAEKMKLKAGAYQQYGEAAKMAMVLECLPQI 367

  Fly   391 AAEVAAPLAKTDEIVLIGG-NDNITNDVTRLVAQLPPSINALTGVDLSKV--LSKIPGAKA 448
            ||:|:|||||.||||::.| |..||.::.||:|::|.|:.|||||||:|:  :.|..|..|
Frog   368 AAKVSAPLAKVDEIVILSGENSKITGEMNRLLAEVPASVQALTGVDLTKIPLIQKATGILA 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Flo2	NP_001259553.1	SPFH_flotillin	34..201	CDD:259798	108/166 (65%)
		PHB	110..281	CDD:214581	127/170 (75%)
		SPFH_like	<286..374	CDD:302763	47/87 (54%)
		Flot	337..>410	CDD:292597	49/73 (67%)
flot2	NP_001011034.1	Flot	6..417	CDD:330594	273/433 (63%)
flot2	NP_001011034.1	SPFH_flotillin	34..178	CDD:259798	108/166 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1718
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3293
Inparanoid	1	1.050	555	1.000	Inparanoid score	I1102
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D340567at33208
OrthoFinder	1	1.000	-	-		FOG0001627
OrthoInspector	1	1.000	-	-		oto102766
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5086
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060