DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Flo2 and flot2b

DIOPT Version :9

Sequence 1:	NP_001259553.1	Gene:	Flo2 / 32425	FlyBaseID:	FBgn0264078	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_956933.1	Gene:	flot2b / 393612	ZFINID:	ZDB-GENE-040426-1368	Length:	428	Species:	Danio rerio

Alignment Length:	451	Identity:	284/451 - (62%)
Similarity:	353/451 - (78%)	Gaps:	26/451 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNIHTTGPNEALIVSGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLNVMTLNPMCENVETSQGV 65
            ||...|.||||||:|||.||||..|..:||||||||||::|.||::|.:|||.|.||:|||::||
Zfish     1 MGCCLTVGPNEALVVSGACCGSDAKTYVVGGWAWAWWLISDTQRITLEIMTLQPKCEDVETAEGV 65

  Fly    66 PLTVTGVAQCKIMKSSSYKQTDYHNDEMMNVYYFHHQADELLGTASEQFLGKSVKEIKQTILQTL 130
            .:|||||||.|:|       ||                .:||..|.||||||||.|||..:||||
Zfish    66 AITVTGVAQVKVM-------TD----------------KDLLAIACEQFLGKSVMEIKAVVLQTL 107

  Fly   131 EGHLRAILGTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLASLGKAQT 195
            |||||:||||||||::|:||||||.|||||||||||||||||||||||||||.:.||:||||.||
Zfish   108 EGHLRSILGTLTVEQIYQDRDQFARLVREVAAPDVGRMGIEILSFTIKDVYDKLDYLSSLGKTQT 172

  Fly   196 AVVKRDADAGVAEANRDAGIREAECEKSAMDVKYSTDTKIEDNTRMYKLQKANFDQEINTAKAES 260
            |.|:||||.|||||.||||||||||:|..||||:..|||:.|:.|..:||||.|:||:||.||||
Zfish   173 AAVQRDADIGVAEAERDAGIREAECKKEMMDVKFLADTKMADSKRELELQKAAFNQEVNTKKAES 237

  Fly   261 QLAYELQAAKIRQRIRNEEIQIEVVERRKQIEIESQEVQRKDRELTGTVKLPAEAEAFRLQTLAQ 325
            ||||||||||.:|:||.|||:||||:|:|||.||.:|::|.::||..|||.||||||::::.||:
Zfish   238 QLAYELQAAKEQQKIRLEEIEIEVVQRKKQISIEEREIERTEKELIATVKRPAEAEAYKMEQLAE 302

  Fly   326 AKQCQTIEGARAEAERIRKIGSAEAHAIELVGKAEAERMRMKAHVYKQYGDAAIMNIVLESLPKI 390
            ..:.|.:..|:||||:|||||.|||.:|..||||||||||:||..|:|||:||...:||::||||
Zfish   303 GYKMQKVLTAQAEAEKIRKIGEAEAISISSVGKAEAERMRLKAEAYQQYGEAAKTALVLDALPKI 367

  Fly   391 AAEVAAPLAKTDEIVLIGGN-DNITNDVTRLVAQLPPSINALTGVDLSK--VLSKIPGAKA 448
            |.:|:||||:|:|||::.|: ..:|.:|.||:|:||.|:||||||||||  :|.|:.||:|
Zfish   368 AGKVSAPLARTNEIVILSGDGSRVTGEVNRLLAELPVSVNALTGVDLSKMPLLQKLTGAQA 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Flo2	NP_001259553.1	SPFH_flotillin	34..201	CDD:259798	106/166 (64%)
		PHB	110..281	CDD:214581	130/170 (76%)
		SPFH_like	<286..374	CDD:302763	49/87 (56%)
		Flot	337..>410	CDD:292597	47/72 (65%)
flot2b	NP_956933.1	YqiK	5..425	CDD:225177	279/442 (63%)
		SPFH_flotillin	34..178	CDD:259798	106/166 (64%)
		Flot	313..>388	CDD:292597	48/74 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596162
Domainoid	1	1.000	277	1.000	Domainoid score	I1693
eggNOG	1	0.900	-	-		E1_COG2268
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3293
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1074
OMA	1	1.010	-	-		QHG52449
OrthoDB	1	1.010	-	-		D340567at33208
OrthoFinder	1	1.000	-	-		FOG0001627
OrthoInspector	1	1.000	-	-		otm25203
orthoMCL	1	0.900	-	-		OOG6_106546
Panther	1	1.100	-	-	O	PTHR13806
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4918
SonicParanoid	1	1.000	-	-		X5086
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800