DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eo and ninaG

DIOPT Version :9

Sequence 1:	NP_572986.1	Gene:	Eo / 32423	FlyBaseID:	FBgn0030597	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_650070.1	Gene:	ninaG / 41369	FlyBaseID:	FBgn0037896	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	635	Identity:	164/635 - (25%)
Similarity:	264/635 - (41%)	Gaps:	96/635 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ISLMQSVAIALNASSLALANNTAWPLQHEPPEDRLEIE---SYDYIVVGAGSAGSIVASRLSELC 112
            |.::..:.|...:..:.||...   |::..|.....:|   ::||::||.|:.||.:.|.|::..
  Fly     8 ILVLAGIVIGFLSIIVVLAGTL---LKNSVPNVLAPVERHFAFDYVIVGGGTGGSTLTSLLAKNS 69

  Fly   113 QVKVLLLEEGQLPPLESEIFGLTGALHHD-ERYMFLEEAVPNPKCCQAMASMHGCVWWHGRMMGG 176
            ...|||:|.|....|.|.|..||...... ..:.||  :||.....:.:.....|: ..|:.:||
  Fly    70 NGSVLLIEAGGQFGLLSRIPLLTTFQQKGINDWSFL--SVPQKHSSRGLIERRQCL-PRGKGLGG 131

  Fly   177 GGAINGNIFIPGSRENFRRW----NSTGWDWTQVHKTYSRLQQRLNPSYLQPNKLNLKLANLIYS 237
            ...:|..:...|...:|..|    |.:.|.|.|: :::....:..||..|:..:...||...:..
  Fly   132 SANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQM-RSFMAAAKPKNPDMLEIPRRYSKLTEALEE 195

  Fly   238 GSAELGVPRMKQPLIAGATFGYTHHV----PVTVNQRRRASSARLYLANDQVNRRGNLKVIRGAQ 298
            ..|:               |.|...:    ...:....|.|..:.:|  :.|....||:::..|.
  Fly   196 AQAQ---------------FAYKDWIFRRSLYNIRNGLRHSVVQQFL--NPVIHHSNLRLLPDAL 243

  Fly   299 VQRVLLNAAGS---RATGVIYTLNGVEHTAKTLG-----EVILSAGTLNSAKLLLLSGIGPREEL 355
            |:|:.|  |.|   :||.::..:...|:..|...     |:||.||...:.:||:.||||....|
  Fly   244 VKRIQL--APSPFLQATSILVGIKDEENREKEFSIEVRRELILCAGAYQTPQLLMASGIGDVSAL 306

  Fly   356 QRWNITTHQDLP-VGRNLQDHGMMPLFLLFGSNCAVNSTRDPTENPYA---PVSITQYLLDNQKG 416
            ::..|.....|| ||.||.||..:|||:..|       ...||.|...   |:::..| |.:..|
  Fly   307 KKLGIPAQHSLPLVGHNLHDHFNLPLFVSMG-------VTGPTLNQNTLLNPMTLINY-LSSGSG 363

  Fly   417 PLASGFYMMGYINSSSPSSSRGEPDLHVVAHTLLPKG--------STGSFGYLGFRPELIQAQQD 473
            ||.: |.::|.:.|   ....|.|...:   |....|        |..:|....|| .|.....:
  Fly   364 PLGN-FGVLGNVVS---YGGLGAPPYGI---TFFGAGAIDESALMSISNFKGPAFR-ALFPRYYN 420

  Fly   474 ILQKGDLLQIMGSLLRPLSHGKVSLSSKNSADQAKIENHYGEAVEDQQTLLRYVRYIQKLSKTRP 538
            ..|:|  ..::.|.|:|.|.|.|.|.:::......|:.:|..:.||....:..:|...:|..:..
  Fly   421 SSQEG--FVVISSCLQPKSRGSVGLLNRHMRRNPLIDPNYLSSEEDVACTISAIRSAVELVNSTA 483

  Fly   539 FRRCGLRLWKPPLHECDTLA---------ADSDDYWLCYIRYFYVGAWHSVGTCRMAPRKGVDSQ 594
            |.....|:..|.:.||....         ..||.|..|.:|:..:|:.|..|||.:
  Fly   484 FAALHPRIHWPRVQECSNFGPFERDFFDNRPSDQYLECLMRHVGLGSHHPGGTCAL--------- 539

  Fly   595 ENGGVVDERLRVHGVKGLRVVDASIMPELPAGNTNGPAMMIGEKGAQMIL 644
              |.|||.:||:.||..:||||||::|...:||.|...:.|..:.|..||
  Fly   540 --GSVVDSQLRLKGVSNVRVVDASVLPRPISGNPNSVVVAIALRAASWIL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eo	NP_572986.1	BetA	88..649	CDD:225186	158/598 (26%)
		NADB_Rossmann	185..375	CDD:304358	50/206 (24%)
		GMC_oxred_C	490..638	CDD:282984	45/156 (29%)
ninaG	NP_650070.1	BetA	72..588	CDD:225186	148/568 (26%)
		NADB_Rossmann	119..327	CDD:304358	55/228 (24%)
		GMC_oxred_C	435..582	CDD:282984	45/157 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446449
Domainoid	1	1.000	69	1.000	Domainoid score	I3423
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm47571
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.850