Protein Alignment CG12398 and Chdh

DIOPT Version :9

• Sequence 1: NP_572985.1
• Gene: CG12398 / 32422
• FlyBaseID: FBgn0030596
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001129712.1
• Gene: Chdh / 218865
• MGIID: 1860776
• Length: 596
• Species: Mus musculus
• Alignment Length: 605
• Identity: 214/605 - (35%)
• Similarity: 296/605 - (48%)
• Gaps: 107/605 - (17%)

  Fly    54 RESYDFIVIGGGSAGCVLAARLSENPEWSVLLLEAGGDEPLL--------IDLP-QLYPVFQRSP 109
            ::.|.|:|:|.||||||||:||:|:|...|||||||..:.|:        |.:| .|........
Mouse    40 KDEYTFVVVGAGSAGCVLASRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIHMPAALVSNLCDDK 104

  Fly   110 WDWKYLTEPSDRYCLAMEDQRCFWPRAKVLGGCSSINAMMYIRGNRRDYDQWAALGNPGWNYDNI 174
            ::|.|.|||..    .|:.:..:|||.:|.||.||:|||:||||:..||::|...|..||:|.:.
Mouse   105 YNWYYHTEPQP----GMDSRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWHREGAEGWDYAHC 165

  Fly   175 LHYFRKLEDMRVPGFEHSPYHGHGGPISVERYRFPSPLLDIFMRAAQQLGMVHPDGDFNGRSQTG 239
            |.||||.:...:..   :.|.|..||:.|.|.:...||...|::||:|.|....: |.||..|.|
Mouse   166 LPYFRKAQRHELGA---NMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAGYPFTE-DMNGFQQEG 226

  Fly   240 FAPPHGSLRDGLRCSANKGYIRRSWQRPNLDIVLKAFVERIVIDPQSHRAIGVIFEYGLLKHTVR 304
            |.....::..|.|.|....|:.....||||...::..|.|::.  :..||:||.:.....:|...
Mouse   227 FGWMDMTVHQGKRWSTACAYLHPVLSRPNLRAEVQTLVSRVLF--EGTRAVGVEYIKDGQRHKAY 289

  Fly   305 AKREVILSAGSLASPQLLMVSGVGPRDQLEPQGIPVVQHLPGVGGNLQDH------------IST 357
            ..||||||.|::.||||||:||||..|.|....||||.||||||.|||||            |:.
Mouse   290 VSREVILSGGAINSPQLLMLSGVGNADDLRKLDIPVVCHLPGVGQNLQDHLEVYVQQACTQPITL 354

  Fly   358 SGA---------------IYTFDSGQNRHLSFIVPEMMNEQAVEDFVQGSDSFFYAMPVSEVMGF 407
            ..|               .||.| |...||                              |..||
Mouse   355 HSAQKPLRKVCIGLEWLWSYTGD-GATAHL------------------------------ETGGF 388

  Fly   408 FSTRYQDPRLDWPDVQI-FMGSYGYGADGGMIGRRGAAITLDNYAEAFEPVLYQDSFVIAPLLMR 471
            ..:|   |.:..||:|. |:.|.                .:|:..:..:    |:::.:....||
Mouse   389 IRSR---PGVPHPDIQFHFLPSQ----------------VIDHGRKPTQ----QEAYQVHVGTMR 430

  Fly   472 PRSRGYLQLRSADPKVHPLIHANYYDDPHDMAVMVEGLKLAHRLTQTPVMQSLNATMNIYEWRNC 536
            ..|.|:|:||||:|:.||:||.||.....|    ||..:...||::....|...|.....|.:
Mouse   431 ATSVGWLKLRSANPRDHPVIHPNYLSTETD----VEDFRQCVRLSREIFAQEALAPFRGKELQ-- 489

  Fly   537 PEVEYLSDAFWECLARFYSQTIYHPVGTCKMAPASDPAGVVDPRLRVRGMRGLRVIDASIMPTIP 601
            |.....||...:...|..:.:.|||..||||..:|||..|||.:.:|.|:..|||:||||||::.
Mouse   490 PGSHVQSDKEIDAFVRAKADSAYHPSCTCKMGRSSDPTAVVDAQTKVIGVENLRVVDASIMPSVV 554

  Fly   602 TGNTNAPTLMLAERGADIIK 621
            :||.||||:|:||:.|||||
Mouse   555 SGNLNAPTVMIAEKAADIIK 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12398	NP_572985.1	PRK02106	55..632	CDD:235000	214/604 (35%)
		NADB_Rossmann	58..>93	CDD:304358	22/34 (65%)
		NADB_Rossmann	129..354	CDD:304358	93/224 (42%)
		GMC_oxred_C	472..615	CDD:282984	58/142 (41%)
Chdh	NP_001129712.1	PRK02106	42..588	CDD:235000	214/603 (35%)
		NAD_binding_8	47..>76	CDD:290186	20/28 (71%)
		GMC_oxred_N	118..341	CDD:279121	95/228 (42%)
		GMC_oxred_C	432..569	CDD:282984	59/142 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I2232
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm42468
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860