DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fiz and CG9519

DIOPT Version :9

Sequence 1:	NP_001285254.1	Gene:	fiz / 32420	FlyBaseID:	FBgn0030594	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_572978.1	Gene:	CG9519 / 32415	FlyBaseID:	FBgn0030589	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	221/592 - (37%)
Similarity:	315/592 - (53%)	Gaps:	61/592 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LSQPYDFVVIGAGSAGSVVASRLSENPDWRVLVLEAGGDPPVESELPALFFGLQHTNFTWNYFTE 129
            ::..|||:|:|||:||..:|:||||||.||||:|||||......::|.:...||.....|.|.||
  Fly    58 ITTKYDFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPENYAMDIPIVAHLLQLGEINWKYKTE 122

  Fly   130 PSDEACQAMKDGRCYWPRGKMLGGSGGVNAMLYVRGNRRDFDGWAAMGSTGWSYDQVMPFFEK-- 192
            ||:..|.||.:.||.|||||::|||..:|.|:|.||||||:|.||.:|:.||||::|:|:|:|
  Fly   123 PSNSYCLAMNNNRCNWPRGKVMGGSSVLNYMMYTRGNRRDYDRWARLGNPGWSYEEVLPYFKKYE 187

  Fly   193 -SVTPQG--NATHPKGYVTLKPFERKDNDIHQMIIDGGRELGQPYVERFQEGSDTG-----YSHV 249
             ||.|..  |.....|.|.:...|.:.. |....:...::.|.|      .|...|     .|::
  Fly   188 GSVVPDADENLVGRNGPVKVSYSETRTR-IADAFVGATQDAGLP------RGDYNGDKQIRVSYL 245

  Fly   250 PGTVRQGQRMSTGKGYLGAVSKSRPNLHVVKNALVTKLDLDGETVKE----VKFERAGVTHRVKV 310
            ...:....|.|:.:.||..:...|.||||.|||||||:.:|.:|...    ||.:  |...::..
  Fly   246 QANIYNETRWSSNRAYLYPIKGKRRNLHVKKNALVTKILIDPQTKSAFGIIVKMD--GKMQKILA 308

  Fly   311 TKDVVISAGAIDSPALLLRSGIGPSKHLKELGIPVKLDLPGVGRNLQDHVLVPVFLRLDEGQGEP 375
            .|:|::|||||::|.||:.||:||:|||:|:||....|| .||.|||||: .|....|.......
  Fly   309 RKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADL-AVGYNLQDHI-APAISFLCNVSSLQ 371

  Fly   376 MTDQAALDSIYQYLIYRAGPLAAHSTASLVGFINTNASSDGAYPDTENHHMFFQRAHHASLELFT 440
            .::....:::..:|..| |.|........:.|.   |..|...||.           .|.:|||.
  Fly   372 TSEMFRSEAMSDFLKGR-GVLRIPGGVEAISFY---ALDDARNPDA-----------WADMELFV 421

  Fly   441 KG------------LSIQDQYTEVLQEYL--KDSHLLCVFVLLSHPAARGELRLKSTDPKVPPIL 491
            .|            |.||....|.:...|  :.::...:|.::....:||.::|||.:|:..|.:
  Fly   422 VGGGLQTNLALRLALGIQSNIYETMFGELERQSANGFLIFPMILRAKSRGRIKLKSRNPEEHPRI 486

  Fly   492 TSNYLTESEDVATLMRGIRYIESLEQTKAFQ---DHLAEIARIPIKECDQIENYRSEEYWRCYAK 553
            .:||.....|:...:|||....||....||:   .||.| .|||  .|.:.: ::|..||.|||:
  Fly   487 YANYFANPYDMNITVRGIEQAVSLLDMPAFKAIGAHLLE-KRIP--NCAKYK-WKSSAYWACYAR 547

  Fly   554 YFTVTCYHQSGTVKMGPDYDNEACVSQRLKVHGLENLRVADASIMPAVVSANTNAATVMIGERAA 618
            :||.|.||.|||.||||..|..|.|..||:|||::.|||.||||||.::|.:.|....:|.|:||
  Fly   548 HFTFTIYHYSGTAKMGPRSDPSAVVDARLRVHGIDKLRVVDASIMPYLISGHPNGPVYLIAEKAA 612

  Fly   619 HFIQEDY 625
            ..|:||:
  Fly   613 DMIKEDH 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fiz	NP_001285254.1	PRK02106	66..621	CDD:235000	218/585 (37%)
		NADB_Rossmann	70..>105	CDD:304358	24/34 (71%)
		NADB_Rossmann	142..359	CDD:304358	92/230 (40%)
		GMC_oxred_C	472..617	CDD:282984	63/147 (43%)
CG9519	NP_572978.1	PRK02106	59..616	CDD:235000	218/586 (37%)
		NADB_Rossmann	63..>99	CDD:304358	24/35 (69%)
		NADB_Rossmann	132..356	CDD:304358	92/233 (39%)
		GMC_oxred_C	468..611	CDD:282984	63/146 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446463
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	11	10.800