DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fiz and CG45065

DIOPT Version :9

Sequence 1:	NP_001285254.1	Gene:	fiz / 32420	FlyBaseID:	FBgn0030594	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001285251.1	Gene:	CG45065 / 19835504	FlyBaseID:	FBgn0266435	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	603	Identity:	224/603 - (37%)
Similarity:	335/603 - (55%)	Gaps:	62/603 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VDYVGDLSQP------YDFVVIGAGSAGSVVASRLSENPDWRVLVLEAGGDPPVESELPALFFGL 117
            ||....:.:|      |||||||.||||:|||:||||..:|.||:||||||....|::|||...|
  Fly    28 VDPENKVQEPTVIRRQYDFVVIGGGSAGAVVANRLSEVRNWTVLLLEAGGDETEISDVPALAGYL 92

  Fly   118 QHTNFTWNYFTEPSD--EACQAMKDGRCYWPRGKMLGGSGGVNAMLYVRGNRRDFDGWAAMGSTG 180
            |.|...|.|.|.||.  :.|||||..||:|||||:||||..:|||:||||::.|::.||::|:.|
  Fly    93 QLTELDWKYQTTPSSTRQYCQAMKGDRCFWPRGKVLGGSSVLNAMVYVRGSKNDYNHWASLGNPG 157

  Fly   181 WSYDQVMPFFEKS---------VTPQGNATHPKGYVTLK--PFERKDNDIHQMIIDGGRELGQPY 234
            |.||.::.:|.||         .||....   .||:|::  |:.   ..:....:..|.|:|  |
  Fly   158 WDYDSMLKYFLKSEDVRNPYLAKTPYHET---GGYLTVQEAPWR---TPLSIAFLQAGIEMG--Y 214

  Fly   235 VERFQEGS-DTGYSHVPGTVRQGQRMSTGKGYLGAVSKSRPNLHVVKNALVTKLDLDGE-TVKEV 297
            ..|...|: .||:.....|:|:|.|.||||.::..| :.|.|..|:.:|..|::..|.: ....|
  Fly   215 ENRDINGAQQTGFMLTQSTIRRGARCSTGKAFIRPV-RQRKNFDVLLHAEATRILFDKQKRAIGV 278

  Fly   298 KFERAGVTHRVKVTKDVVISAGAIDSPALLLRSGIGPSKHLKELGIPVKLDLPGVGRNLQDHVLV 362
            ::.|.|..:.|.|.::|:.||||:::|.||:.||:||::||:|..|||..||| ||.|:||||.:
  Fly   279 EYMRGGRKNVVFVRREVIASAGALNTPKLLMLSGVGPAEHLQEHNIPVISDLP-VGNNMQDHVGL 342

  Fly   363 ---------PVFLRLDEGQGEPMTDQAALDSIYQYLIYRAGPLAAHSTASLVGFINTNASSDGA- 417
                     |:.:..:..|..|::        .:|::...||: ..|....|.|:||.......
  Fly   343 GGLTFVVDAPLTVTRNRFQTIPVS--------MEYILRERGPM-TFSGVEGVAFLNTKYQDPSVD 398

  Fly   418 YPDTENHHMFFQRAHHASL-----ELFTKGLSIQDQYTEVLQEYLKDSHLLCVFVLLSHPAARGE 477
            :||.:.|..      .:|:     |...|.|:::|.:...:.:.|:.|....:..||..|.:.|.
  Fly   399 WPDVQFHFC------PSSINSDGGEQIRKILNLRDGFYNTVYKPLQHSETWSILPLLLRPKSTGW 457

  Fly   478 LRLKSTDPKVPPILTSNYLTESEDVATLMRGIRYIESLEQTKAFQDHLAEIARIPIKECDQIENY 542
            :||.|.:|:..|.:..||....||:..|:.||:...::..|:|||...:.:..||:..|..:. :
  Fly   458 VRLNSRNPQHQPKIIPNYFAHQEDIDVLVEGIKLAINVSNTQAFQRFGSRLHNIPLPGCRHLP-F 521

  Fly   543 RSEEYWRCYAKYFTVTCYHQSGTVKMGPDYDNEACVSQRLKVHGLENLRVADASIMPAVVSANTN 607
            :|.|||.|..|.||.|.||.:||.:|||.:|..|.|..||:|:|:..:||.||||||.:|:.|.|
  Fly   522 QSNEYWACCIKEFTFTIYHPAGTCRMGPSWDVTAVVDPRLRVYGVSGVRVVDASIMPTIVNGNPN 586

  Fly   608 AATVMIGERAAHFIQEDY 625
            |..:.|||:|:..|:||:
  Fly   587 APVIAIGEKASDLIKEDW 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fiz	NP_001285254.1	PRK02106	66..621	CDD:235000	219/590 (37%)
		NADB_Rossmann	70..>105	CDD:304358	26/34 (76%)
		NADB_Rossmann	142..359	CDD:304358	88/229 (38%)
		GMC_oxred_C	472..617	CDD:282984	59/144 (41%)
CG45065	NP_001285251.1	PRK02106	42..601	CDD:235000	218/584 (37%)
		NADB_Rossmann	117..339	CDD:304358	88/231 (38%)
		GMC_oxred_C	452..596	CDD:282984	59/144 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469734
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.890