Protein Alignment toporsa and Topors

DIOPT Version :9

• Sequence 1: NP_001292484.1
• Gene: toporsa / 324197
• ZFINID: ZDB-GENE-030131-6401
• Length: 999
• Species: Danio rerio
• Sequence 2: NP_001261083.1
• Gene: Topors / 37188
• FlyBaseID: FBgn0267351
• Length: 1038
• Species: Drosophila melanogaster
• Alignment Length: 1064
• Identity: 244/1064 - (22%)
• Similarity: 408/1064 - (38%)
• Gaps: 274/1064 - (25%)

Zfish    23 SPESKCPICLDHFKNISYLDVCLHKFCFCCIHEWSKNKAECPLCKQPFNSFYHTIKSEDDYKRFD 87
            ||...|.|||...:...:.|.|:|:|||.|:.||||.|.|||||||||.:..|.:::.|||.|:.
  Fly    97 SPPPNCAICLSRCRRKCFTDSCMHQFCFKCLCEWSKIKPECPLCKQPFRTIIHNVRTLDDYDRYP 161

Zfish    88 LR-----PTENGSFGNMAGQRFRY------RTTLTGD-----------------------RRPVQ 118
            ::     ||||.|......:|.||      :..:..|                       ||...
  Fly   162 VQTTSPVPTENPSLRYHIVRRPRYTPLVQNQAVIVNDIEAAIAAGAAGEDVLSAAEVAAGRRSYS 226

Zfish   119 RRTSPPPDHGIIFEGLRGSLPQ--RHNRDLHSMIRRLTVRQRRESEGRSLRSLQDQEVVKFRRAL 181
            |           ||..|..|..  :|::|              .|...||..|       :||.:
  Fly   227 R-----------FEPYRSELMNYYQHDQD--------------ASTSGSLSQL-------WRRYV 259

Zfish   182 YRRGVQVQSVQDG--GRTRETSAEFFKRNPACLHRLVPWLRRELTVLYGAHGSLVNIVQHIIMTL 244
            |.|.:....|.|.  |..||.||.|::.|||.:|||:||:.|::..|.......||.|..::..|
  Fly   260 YDRKLYALPVSDSVTGHFREWSARFYRNNPAQIHRLMPWIHRDIMCLLRNAAHSVNTVMTLMSDL 324

Zfish   245 ITRHNLDDQAVQHELRPFLLSHTEHFLHEFLSFARSPFNMEAYDQRAVYD-----------LPRP 298
            :...:|.....:..|.|:|...|.||:||..:|||||:::..||....|.           |...
  Fly   325 LPMTSLLGPTFRRRLSPYLGERTSHFIHELFNFARSPYDINGYDHVVQYSARVAEEVEVDLLDMV 389

Zfish   299 SGESSSSENSVIAISEDESESLVSG-AQDFATPRVTSSQTAWDDETPGPSYS------SERSQVL 356
            ..:||:.::..:.:.:.:::::.:| :.|::.|||..| |:.....||.::|      |:.|::.
  Fly   390 ETQSSNGDDLNLEVGDSDADAINAGFSPDWSPPRVRPS-TSVIVTNPGATHSFSVTMASDGSELP 453

Zfish   357 PVHVRDSDSDSSVGEAVMPI-------AAVRHQ----------DHPAN----------------- 387
            .:.:|.:   ::||...:.|       |||..:          |..||
  Fly   454 GISIRRT---TNVGSQTVAINLSMRRPAAVASEEPEVIEIDDGDAAANAEVAAINDGSNTSRRHA 515

Zfish   388 ----PSTIQPE-EDHSSSNDED-CVIIGYVKPVAERTPELVQLSSDSENS----ETEQNASP--- 439
                |.|...| |..|||.||| ||.:..:||...||||.|.|.|:|::.    ..:..|:|
  Fly   516 GATLPVTAHIELESSSSSGDEDECVFVLELKPPHMRTPEQVSLDSNSDSDVVFVNEQHEAAPDAI 580

Zfish   440 ---RNSQAPQHIR------FISDSDASPTASQ-----------------RPLRGPASSSRSFEDT 478
               |::|:|..:.      |:..|.:...|::                 |.||    |.||.:.
  Fly   581 AENRSTQSPLDLASRDQGLFMGPSTSGAAANRGKNWKLVMAQTRRLDQLRTLR----SIRSKKS- 640

Zfish   479 SIQLRKNSKYDNTFSGSREGSSQSKRIHSSSHRKKQPLCKESKNKQRGEKETSRHSSSYWHSYSY 543
                |::|....:.|||...|..|...|.||...:......:.|.:..:|:
  Fly   641 ----RRSSMPARSDSGSSPSSCSSSSFHFSSSSDEDSSDSSTTNSEPPKKK-------------- 687

Zfish   544 YSHDNSRKAYTETSSSYTSYYRSVNDQFGSRSHGKRRCRDLLDRSRSRSNSRISQSNRRNRSRSR 608
                 |||......       ||..:..|.|:..||:.:|  .........:|||...:.:..|.
  Fly   688 -----SRKRVANNK-------RSKKESIGKRTSRKRKAKD--QNMEMLEQQQISQKKPQRQPESS 738

Zfish   609 SNSRISRSNQRNRSHSRSNSGKSQSNRRNRSCSRSYSRTSPFNERNRRHSRSNSR-KSQSNRHNR 672
            |:|. |.|:..:...|..:||:..:| .|:|.|.|...::.    |.:.|...:. |:::...:|
  Fly   739 SDSP-SSSDDESGGDSSESSGQPNTN-NNKSSSDSDDDSAV----NMQLSALRATLKAEATLEDR 797

Zfish   673 SCSRSYSRTSPFNERNRRHSRSNSRKSQSNRHNRSCSRSYSRTSPFNQRNRRHSRSNSRISQSSR 737
            ...:...:....::....|||......:.|  ...||                         :.:
  Fly   798 KPVKLELQLPDDDQAGPLHSRMTPSPREDN--EPGCS-------------------------APK 835

Zfish   738 QNRSLSRSNSRKGYSNRRNRNHSRSSSRVSQSSQRNRSHSRSNFRIKSSSY------KSQDEKYQ 796
            :.||.|.||           ..|:|:|..|.|:..:.|...|:|...::.:      :......:
  Fly   836 RRRSCSHSN-----------QSSQSASLASSSTATSSSAPLSSFAWGAAGFSGDPLMRGHPAMEE 889

Zfish   797 RSLSRSLYSNNDVRSRSRSSSRINTSSRQDRRRSRSSSR-MNSSS---SRQTSCHDKYGKKRMYK 857
            ..::.||.      ..|..:..:|.....:...|..:|. |.|::   |.||...|....:..:.
  Fly   890 HDIANSLI------ELSTLTQPVNIGLFNEHYNSAENSMGMLSNTLCDSPQTLAADDANLENYFD 948

Zfish   858 TKHHEKPSRQSSSKSVGDSDEVGGKKK-----------KKKHTKRRKTRSPSIDDRSEGHSQRHH 911
            |....:.||:..:.|:..:.:|.|:.:           :::..:..:......||:.|..:....
  Fly   949 TDADPEASRERDAYSLEAAIDVVGESELQIAEDTATATEEQDEEDEEDEDQEEDDQEEEKAAEEE 1013

Zfish   912 KRKKKHKKKSKRHNSKERTRKLSP 935
            :.:::....|..|:..:..:.|.|
  Fly  1014 EEEEEDDDDSDNHDENDENQGLLP 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toporsa	NP_001292484.1	RING-HC_Topors	28..67	CDD:319488	20/38 (53%)
		RING-HC finger (C3HC4-type)	28..66	CDD:319488	19/37 (51%)
		RRM	635..>749	CDD:330708	19/114 (17%)
Topors	NP_001261083.1	RING	102..144	CDD:238093	23/41 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579333
Domainoid	1	1.000	138	1.000	Domainoid score	I4802
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3836
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003652
OrthoInspector	1	1.000	-	-		otm24963
orthoMCL	1	0.900	-	-		OOG6_104232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9253
SonicParanoid	1	1.000	-	-		X4653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.820