DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9512 and ninaG

DIOPT Version :9

Sequence 1:	NP_001285253.1	Gene:	CG9512 / 32419	FlyBaseID:	FBgn0030593	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_650070.1	Gene:	ninaG / 41369	FlyBaseID:	FBgn0037896	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	621	Identity:	165/621 - (26%)
Similarity:	260/621 - (41%)	Gaps:	133/621 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 YDFIVIGSGTSGAVVAGRLAEVKNWKVLLLEAGGD------PPIETEFVAWHMATQFSEWDWQYH 116
            :|::::|.||.|:.:...||:..|..|||:||||.      .|:.|.|      .|....||.:.
  Fly    47 FDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAGGQFGLLSRIPLLTTF------QQKGINDWSFL 105

  Fly   117 SKPNGRACMAMKGESCHWPRGKMLGGTNGMNAMIYARGTRKDFDDWEERGN-PGWGYDEVLKHFR 180
            |.|...:...:.......||||.|||:..:|.|::..|...|||.|.:..| ..|.:.:
  Fly   106 SVPQKHSSRGLIERRQCLPRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQ------ 164

  Fly   181 KAEDLRSTRPDYKPGDHGVGGPMGL---NNYVSDNEFRTTIRAGMQEMGYGSAPDFTEGSFVGQM 242
                :||.....||.:     |..|   ..|       :.:...::|    :...|....::.:.
  Fly   165 ----MRSFMAAAKPKN-----PDMLEIPRRY-------SKLTEALEE----AQAQFAYKDWIFRR 209

  Fly   243 DILGTQDGGRRITTARSHLKK--NTPNLHILRHAHVKKINL----------------DRNNRAES 289
            .:...::|.|. :..:..|..  :..||.:|..|.||:|.|                |..||
  Fly   210 SLYNIRNGLRH-SVVQQFLNPVIHHSNLRLLPDALVKRIQLAPSPFLQATSILVGIKDEENR--- 270

  Fly   290 VTFVHRGKKEYTVKASKEVIVSAGAIGSPQILLLSGIGPADHLKSLGIPVKLDLP-VGENLKDHA 353
                   :||::::..:|:|:.|||..:||:|:.||||....||.||||.:..|| ||.||.||.
  Fly   271 -------EKEFSIEVRRELILCAGAYQTPQLLMASGIGDVSALKKLGIPAQHSLPLVGHNLHDHF 328

  Fly   354 SLPMIFQ-------IDKSTARKPTEEELVDAMYNLL------MGRYSKLLHHEATALTGFINTTS 405
            :||:...       ::::|...|.      .:.|.|      :|.:..|         |  |..|
  Fly   329 NLPLFVSMGVTGPTLNQNTLLNPM------TLINYLSSGSGPLGNFGVL---------G--NVVS 376

  Fly   406 IEGPNPDIQTTNFF--------SLMQSPELKGYVAATGFNDRVAKSILSANQETNTYITYLLHLK 462
            ..|.........||        :||.....||......|     ....:::||  .::.....|:
  Fly   377 YGGLGAPPYGITFFGAGAIDESALMSISNFKGPAFRALF-----PRYYNSSQE--GFVVISSCLQ 434

  Fly   463 PFSAGSLTLQSANYLDAPIIDPGYMTDERDVDTYIRALNIYKNLPNTKAFSEREAALHKLDLEAC 527
            |.|.||:.|.:.:....|:|||.|::.|.||...|.|:.....|.|:.||:.....:|...::.|
  Fly   435 PKSRGSVGLLNRHMRRNPLIDPNYLSSEEDVACTISAIRSAVELVNSTAFAALHPRIHWPRVQEC 499

  Fly   528 NGL---------TYQSDDYWRCYIRHMTTTVYHPVGTTRMGPSTDPTAVVDPQLRVHGAKGLRVI 583
            :..         ...||.|..|.:||:....:||.||..:|      :|||.|||:.|...:||:
  Fly   500 SNFGPFERDFFDNRPSDQYLECLMRHVGLGSHHPGGTCALG------SVVDSQLRLKGVSNVRVV 558

  Fly   584 DASIMPDIVGANTNAACIMIAEKGAD-MIKEEYLGG 618
            |||::|..:..|.|:..:.||.:.|. ::|.|...|
  Fly   559 DASVLPRPISGNPNSVVVAIALRAASWILKSELQAG 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9512	NP_001285253.1	PRK02106	56..612	CDD:235000	162/613 (26%)
		NADB_Rossmann	120..352	CDD:304358	65/254 (26%)
		GMC_oxred_C	463..606	CDD:282984	49/151 (32%)
ninaG	NP_650070.1	BetA	72..588	CDD:225186	154/588 (26%)
		NADB_Rossmann	119..327	CDD:304358	65/244 (27%)
		GMC_oxred_C	435..582	CDD:282984	49/152 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446446
Domainoid	1	1.000	69	1.000	Domainoid score	I3423
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm47571
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.850