Protein Alignment CG9514 and CHDH

DIOPT Version :9

• Sequence 1: NP_572981.1
• Gene: CG9514 / 32418
• FlyBaseID: FBgn0030592
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_060867.2
• Gene: CHDH / 55349
• HGNCID: 24288
• Length: 594
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 218/581 - (37%)
• Similarity: 314/581 - (54%)
• Gaps: 61/581 - (10%)

  Fly    95 YDFIIIGGGSAGTVLASRLSEIPHWKILLLEAGGHETEISDVPLLSLYLH----------KSKMD 149
            |.::::|.||||.|||.||:|.|..::||||||..:. ::....||..:|          ..:.:
Human    41 YSYVVVGAGSAGCVLAGRLTEDPAERVLLLEAGPKDV-LAGSKRLSWKIHMPAALVANLCDDRYN 104

  Fly   150 WKYRTQPQPTACQAMKDKRCCWTRGKVLGGSSVLNTMLYIRGNKRDFDQWADFGNPGWSYEDILP 214
            |.|.|:.|    :.:..:...|.||:|.||||.||.|:|:||:..|:::|...|..||.|...||
Human   105 WCYHTEVQ----RGLDGRVLYWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARGWDYAHCLP 165

  Fly   215 YFRKSEDQRNPYLARNKRYHGTGGLWTVQDAPYNTPIGPAFLQAGEEMGYDIV-DVNGEQQTGFG 278
            ||||::...    ....||.|..|...|.....|.|:..|||:|.::.||.:. |:||.||.|||
Human   166 YFRKAQGHE----LGASRYRGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGFG 226

  Fly   279 FYQFNMRRGSRSSTAKSFLRPARLRPNLHVALFSHVTKVLTDPHTKRATGVQFIRDGRLQNVYAT 343
            :....:..|.|.|.|.::|.||..|.||.....:.|::||.:  ..||.||:::::|:....||:
Human   227 WMDMTIHEGKRWSAACAYLHPALSRTNLKAEAETLVSRVLFE--GTRAVGVEYVKNGQSHRAYAS 289

  Fly   344 REVILSAGAIGSPHLMMLSGIGHGEELGRVGIPLVQHLPGVGQNLQDHIAVGGIAFLIDYPISI- 407
            :|||||.|||.||.|:||||||:.::|.::|||:|.||||||||||||:.: .|......||::
Human   290 KEVILSGGAINSPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEI-YIQQACTRPITLH 353

  Fly   408 -VMK--RMVNINTALRYAITEDGPLTSSIGLEAVAFINTKYANASDDWPDMNFMMTSASVMSDGG 469
             ..|  |.|.|.....:..|.:|   ::..||...||.::   .....||:.|....:.|:..|
Human   354 SAQKPLRKVCIGLEWLWKFTGEG---ATAHLETGGFIRSQ---PGVPHPDIQFHFLPSQVIDHG- 411

  Fly   470 SQVKTAHGLTDEFYQEVFGEVNNRDVFGVFPMMLRPKSRGYIKLASKNPLRYPLLYHNYLTHPDD 534
             :|.|    ..|.||...|           ||  |..|.|::||.|.||..:|::..|||:...|
Human   412 -RVPT----QQEAYQVHVG-----------PM--RGTSVGWLKLRSANPQDHPVIQPNYLSTETD 458

  Fly   535 VNVLREGVKAAVAMGETQAMKRFGARYWNKPVPNCKHLTLYTDDYWNCFIRQYTMTIYHMSGTAK 599
            :...|..||....:...:|:    |.:..|.:....|  :.:|...:.|:|....:.||.|.|.|
Human   459 IEDFRLCVKLTREIFAQEAL----APFRGKELQPGSH--IQSDKEIDAFVRAKADSAYHPSCTCK 517

  Fly   600 MGPPTDPWAVVDPQLRVYGIPGLRVIDASIMPAITNGNIHAPVVMIGEKGADMIK---QLW 657
            ||.|:||.||||||.||.|:..|||:||||||::.:||::||.:||.||.||:||   .||
Human   518 MGQPSDPTAVVDPQTRVLGVENLRVVDASIMPSMVSGNLNAPTIMIAEKAADIIKGQPALW 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9514	NP_572981.1	PRK02106	95..679	CDD:235000	218/581 (38%)
		NADB_Rossmann	96..>126	CDD:304358	15/29 (52%)
		NADB_Rossmann	167..391	CDD:304358	99/224 (44%)
		GMC_oxred_C	505..648	CDD:282984	56/142 (39%)
CHDH	NP_060867.2	PRK02106	40..594	CDD:235000	218/581 (38%)
		NADB_Rossmann	44..>149	CDD:304358	40/109 (37%)
		NADB_Rossmann	116..339	CDD:304358	101/228 (44%)
		GMC_oxred_C	430..567	CDD:282984	57/142 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2506
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2510
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm40396
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3702
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.810